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The map label for this gene is cobB [H]

Identifier: 150003994

GI number: 150003994

Start: 1907502

End: 1908200

Strand: Direct

Name: cobB [H]

Synonym: BVU_1428

Alternate gene names: 150003994

Gene position: 1907502-1908200 (Clockwise)

Preceding gene: 150003990

Following gene: 150003995

Centisome position: 36.94

GC content: 40.92

Gene sequence:

>699_bases
ATGAAGAATTTAGTAGTTTTAACAGGTGCTGGAATAAGTGCAGAAAGCGGTATCAGTACATTTCGTGATGCAGGTGGTTT
ATGGGATCAGTATCCGGTGGAACAAGTGGCTACTCCGGAAGGGTATGCGGCAAACCCTAAATTGGTGATTGATTTTTATA
ATGAGCGTCGTAAACAGTTGCTTGCTGTAAAGCCTAACCGGGGGCATGAACTGGTTTCTGAGATGGAAAAGTTCTTTAAT
GTGACTGTTATCACTCAAAATATTGATAATTTGCATGAGCGTGCCGGAAGTTCGCATATTATTCATTTACATGGCGAACT
GACCAAGGTGACATCTAGTTGGCAACCTAATAATCCAGCTTATATTAAAGAATTAAAGCCGGAAGAATATGAGATACATT
TGGGAGACTTGGCCGGAGACGGTTCCCAGTTTCGTCCGTTCATTGTATGGTTTGGTGAATCTGTTCCTATGATTGAAACT
GCAATTGAATATGCTGAAACAGCTGATATCTTTTTAATTATAGGAACTTCGCTTAATGTATATCCTGCTGCCGGTTTGTT
GAATTATGTGCCTGCCCGCACTCCTGTTTATTTAATAGATCCTAAGCAGGTGCCCATTGCATCGGGACGTAAAGTGCATG
TAATTCAGAAAGGTGCGTCCGAAGGAATGGAAGAGCTTAAAAAAATATTAGTGGGATAG

Upstream 100 bases:

>100_bases
ACAAAACGCACAAAGGTAGGTGTTTTATTTGAATGAATCTGTTTTTAACAATTTAATTTTTCTTATTTTTGTGTGTTTAG
TTAAAAGAGGAGGACTAGAA

Downstream 100 bases:

>100_bases
TTTGCAAGTAAACAATTTCCTTGTATATTTGTTATGTATTTAAAGAATATTTAAAACATAAAACAGAGACAATTATGAAA
AAGTACGTTTGCACAGTATG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MKNLVVLTGAGISAESGISTFRDAGGLWDQYPVEQVATPEGYAANPKLVIDFYNERRKQLLAVKPNRGHELVSEMEKFFN
VTVITQNIDNLHERAGSSHIIHLHGELTKVTSSWQPNNPAYIKELKPEEYEIHLGDLAGDGSQFRPFIVWFGESVPMIET
AIEYAETADIFLIIGTSLNVYPAAGLLNYVPARTPVYLIDPKQVPIASGRKVHVIQKGASEGMEELKKILVG

Sequences:

>Translated_232_residues
MKNLVVLTGAGISAESGISTFRDAGGLWDQYPVEQVATPEGYAANPKLVIDFYNERRKQLLAVKPNRGHELVSEMEKFFN
VTVITQNIDNLHERAGSSHIIHLHGELTKVTSSWQPNNPAYIKELKPEEYEIHLGDLAGDGSQFRPFIVWFGESVPMIET
AIEYAETADIFLIIGTSLNVYPAAGLLNYVPARTPVYLIDPKQVPIASGRKVHVIQKGASEGMEELKKILVG
>Mature_232_residues
MKNLVVLTGAGISAESGISTFRDAGGLWDQYPVEQVATPEGYAANPKLVIDFYNERRKQLLAVKPNRGHELVSEMEKFFN
VTVITQNIDNLHERAGSSHIIHLHGELTKVTSSWQPNNPAYIKELKPEEYEIHLGDLAGDGSQFRPFIVWFGESVPMIET
AIEYAETADIFLIIGTSLNVYPAAGLLNYVPARTPVYLIDPKQVPIASGRKVHVIQKGASEGMEELKKILVG

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912664, Length=238, Percent_Identity=36.5546218487395, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI13787215, Length=238, Percent_Identity=37.3949579831933, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI300795542, Length=229, Percent_Identity=36.6812227074236, Blast_Score=138, Evalue=5e-33,
Organism=Escherichia coli, GI308199517, Length=209, Percent_Identity=43.5406698564593, Blast_Score=160, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17541892, Length=219, Percent_Identity=27.3972602739726, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28571445, Length=190, Percent_Identity=30.5263157894737, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 25671; Mature: 25671

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLVVLTGAGISAESGISTFRDAGGLWDQYPVEQVATPEGYAANPKLVIDFYNERRKQL
CCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCEE
LAVKPNRGHELVSEMEKFFNVTVITQNIDNLHERAGSSHIIHLHGELTKVTSSWQPNNPA
EEECCCCCHHHHHHHHHHHEEEEEECCHHHHHHHCCCCCEEEEECCEEEHCCCCCCCCCC
YIKELKPEEYEIHLGDLAGDGSQFRPFIVWFGESVPMIETAIEYAETADIFLIIGTSLNV
EEEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCE
YPAAGLLNYVPARTPVYLIDPKQVPIASGRKVHVIQKGASEGMEELKKILVG
ECCHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLVVLTGAGISAESGISTFRDAGGLWDQYPVEQVATPEGYAANPKLVIDFYNERRKQL
CCCEEEEECCCCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCEEEEEECCCCCCEE
LAVKPNRGHELVSEMEKFFNVTVITQNIDNLHERAGSSHIIHLHGELTKVTSSWQPNNPA
EEECCCCCHHHHHHHHHHHEEEEEECCHHHHHHHCCCCCEEEEECCEEEHCCCCCCCCCC
YIKELKPEEYEIHLGDLAGDGSQFRPFIVWFGESVPMIETAIEYAETADIFLIIGTSLNV
EEEECCCCEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCE
YPAAGLLNYVPARTPVYLIDPKQVPIASGRKVHVIQKGASEGMEELKKILVG
ECCHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928 [H]