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The map label for this gene is murC

Identifier: 150003962

GI number: 150003962

Start: 1868279

End: 1869655

Strand: Reverse

Name: murC

Synonym: BVU_1396

Alternate gene names: 150003962

Gene position: 1869655-1868279 (Counterclockwise)

Preceding gene: 150003963

Following gene: 150003961

Centisome position: 36.21

GC content: 48.15

Gene sequence:

>1377_bases
ATGGACGTTAACACATTAAAATCAGTTTATTTCATCGGTGCCGGAGGTATCGGCATGAGCGCATTGGTACGCTACTTCCT
GTCAAAAGGCAAGAAGGTAGGCGGATATGACCGTACGCCCAGTGAACTGACAGAAAAGCTGATAGAAGAAGGAGCAGCCA
TCCATTACGAAGAAAGCACGGAACTGATAACGGATGCATTCCGCGACCCGGCAACTACATTGGTTGTCTATACTCCGGCT
GTCCCCGATACACATAAAGAGTTTACCTATTTCCGGGAAAACGGTTTCGAGATACATAAACGTTCGCAGGTATTGGGAAT
GCTTACCCATGCAGGAAAAGGACTTTGTGTAGCCGGCACTCACGGTAAGACCACCACTTCTACCATGACAGCCCATCTGT
TACACCAATCCCATGTAGGATGCAACGCCTTTTTGGGAGGCATCTCAAAGAATTACGGCACCAACCTGCTGTTGTCTGAC
AGCAGTGAATACATGGTTATTGAAGCCGACGAGTTCGACCGTTCTTTCCATTGGCTCTCGCCCTACATATCAGTGATTAC
CGCAACCGATCCCGACCATCTGGATATCTACGGAACCAAAGAGGCTTATCTGGAAAGCTTCCGCAAATATACCTCACTCA
TCCAGCCGGGAGGTGCATTGATTGTACGTAAAGGCATCGAGCTGCAACCGGCTTTGCAGAATGGTGTGAAACTGTACACC
TATTCCCAAGAAGAGGGTGACTTTCATGCAGAGAATATCCGTATTGGGAACGGTGAGATTTTCTTTGATTACGTATCACC
CTTGGGAAATATCCCCAATATACAGTTGGGTGTCCCCGTCAGCATCAACATTGAGAACGGGGTAGCCGCCATGGCTTTGG
CGCAGATGAGCGGATTGACTGACGAAGAAATAAAGAGAGGTATGGCAAGTTTCCGCGGAGTAGACCGTCGTTTCGATTTC
AAGATAAAGAACGACAAGGTGGTTTTCCTGAGCGACTATGCGCACCATCCTTCCGAGATAAAACAAAGCATACTCTCCAT
GCGTGCCCTCTATCGGGACAAGAAGCTGACGGCTGTTTTCCAGCCGCACCTCTACACACGTACCCGTGATTTCTACAAAG
ATTTCGCCGACAGCCTTTCCTTGTTGGACGAAGTCATCCTGGTAGATATCTATCCGGCACGCGAGCAACCCATCCCCGGC
GTCACCAGCAAACTGATTTACGACCATCTGCGTCCGGGCATCGAGAAGAGCATGTGCAAGAAAGAAGAAATTCTAGACGT
ACTGAGCAAGAAAGATATAGAAGTATTAATCACCCTGGGTGCGGGCGACATAGATAACTATGTACCCCAAATCTGCGGAT
TACTGAATAAAAAATGA

Upstream 100 bases:

>100_bases
AAAAGTTTAAGTACAAATATTGCTAAATTAGCCTTTACCGACTCAGCCAACGTTATTGCCCGGGAGGTATTCAAACTGGC
TGATAAATACAGAAAAGAAA

Downstream 100 bases:

>100_bases
TAAAGAAAATTCTCATACTCCTGTTTCTGTTGCTGATAACCGCCTACCTTATTGTAGCCGTTACCGCTTTCAACACCAAG
CCTGCCGACCAGGTTTGCAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MDVNTLKSVYFIGAGGIGMSALVRYFLSKGKKVGGYDRTPSELTEKLIEEGAAIHYEESTELITDAFRDPATTLVVYTPA
VPDTHKEFTYFRENGFEIHKRSQVLGMLTHAGKGLCVAGTHGKTTTSTMTAHLLHQSHVGCNAFLGGISKNYGTNLLLSD
SSEYMVIEADEFDRSFHWLSPYISVITATDPDHLDIYGTKEAYLESFRKYTSLIQPGGALIVRKGIELQPALQNGVKLYT
YSQEEGDFHAENIRIGNGEIFFDYVSPLGNIPNIQLGVPVSINIENGVAAMALAQMSGLTDEEIKRGMASFRGVDRRFDF
KIKNDKVVFLSDYAHHPSEIKQSILSMRALYRDKKLTAVFQPHLYTRTRDFYKDFADSLSLLDEVILVDIYPAREQPIPG
VTSKLIYDHLRPGIEKSMCKKEEILDVLSKKDIEVLITLGAGDIDNYVPQICGLLNKK

Sequences:

>Translated_458_residues
MDVNTLKSVYFIGAGGIGMSALVRYFLSKGKKVGGYDRTPSELTEKLIEEGAAIHYEESTELITDAFRDPATTLVVYTPA
VPDTHKEFTYFRENGFEIHKRSQVLGMLTHAGKGLCVAGTHGKTTTSTMTAHLLHQSHVGCNAFLGGISKNYGTNLLLSD
SSEYMVIEADEFDRSFHWLSPYISVITATDPDHLDIYGTKEAYLESFRKYTSLIQPGGALIVRKGIELQPALQNGVKLYT
YSQEEGDFHAENIRIGNGEIFFDYVSPLGNIPNIQLGVPVSINIENGVAAMALAQMSGLTDEEIKRGMASFRGVDRRFDF
KIKNDKVVFLSDYAHHPSEIKQSILSMRALYRDKKLTAVFQPHLYTRTRDFYKDFADSLSLLDEVILVDIYPAREQPIPG
VTSKLIYDHLRPGIEKSMCKKEEILDVLSKKDIEVLITLGAGDIDNYVPQICGLLNKK
>Mature_458_residues
MDVNTLKSVYFIGAGGIGMSALVRYFLSKGKKVGGYDRTPSELTEKLIEEGAAIHYEESTELITDAFRDPATTLVVYTPA
VPDTHKEFTYFRENGFEIHKRSQVLGMLTHAGKGLCVAGTHGKTTTSTMTAHLLHQSHVGCNAFLGGISKNYGTNLLLSD
SSEYMVIEADEFDRSFHWLSPYISVITATDPDHLDIYGTKEAYLESFRKYTSLIQPGGALIVRKGIELQPALQNGVKLYT
YSQEEGDFHAENIRIGNGEIFFDYVSPLGNIPNIQLGVPVSINIENGVAAMALAQMSGLTDEEIKRGMASFRGVDRRFDF
KIKNDKVVFLSDYAHHPSEIKQSILSMRALYRDKKLTAVFQPHLYTRTRDFYKDFADSLSLLDEVILVDIYPAREQPIPG
VTSKLIYDHLRPGIEKSMCKKEEILDVLSKKDIEVLITLGAGDIDNYVPQICGLLNKK

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=467, Percent_Identity=29.7644539614561, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790680, Length=289, Percent_Identity=26.2975778546713, Blast_Score=98, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_BACV8 (A6L070)

Other databases:

- EMBL:   CP000139
- RefSeq:   YP_001298706.1
- ProteinModelPortal:   A6L070
- SMR:   A6L070
- STRING:   A6L070
- GeneID:   5302362
- GenomeReviews:   CP000139_GR
- KEGG:   bvu:BVU_1396
- NMPDR:   fig|435590.6.peg.1318
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51102; Mature: 51102

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVNTLKSVYFIGAGGIGMSALVRYFLSKGKKVGGYDRTPSELTEKLIEEGAAIHYEEST
CCCHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCHH
ELITDAFRDPATTLVVYTPAVPDTHKEFTYFRENGFEIHKRSQVLGMLTHAGKGLCVAGT
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECC
HGKTTTSTMTAHLLHQSHVGCNAFLGGISKNYGTNLLLSDSSEYMVIEADEFDRSFHWLS
CCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHC
PYISVITATDPDHLDIYGTKEAYLESFRKYTSLIQPGGALIVRKGIELQPALQNGVKLYT
CCEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCEEEEE
YSQEEGDFHAENIRIGNGEIFFDYVSPLGNIPNIQLGVPVSINIENGVAAMALAQMSGLT
ECCCCCCEEECEEEECCCCEEEEEHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHCCC
DEEIKRGMASFRGVDRRFDFKIKNDKVVFLSDYAHHPSEIKQSILSMRALYRDKKLTAVF
HHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEE
QPHLYTRTRDFYKDFADSLSLLDEVILVDIYPAREQPIPGVTSKLIYDHLRPGIEKSMCK
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHH
KEEILDVLSKKDIEVLITLGAGDIDNYVPQICGLLNKK
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDVNTLKSVYFIGAGGIGMSALVRYFLSKGKKVGGYDRTPSELTEKLIEEGAAIHYEEST
CCCHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCEEEECCHH
ELITDAFRDPATTLVVYTPAVPDTHKEFTYFRENGFEIHKRSQVLGMLTHAGKGLCVAGT
HHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEECC
HGKTTTSTMTAHLLHQSHVGCNAFLGGISKNYGTNLLLSDSSEYMVIEADEFDRSFHWLS
CCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCEEEEECCCCEEEEECCCCCCCHHHHC
PYISVITATDPDHLDIYGTKEAYLESFRKYTSLIQPGGALIVRKGIELQPALQNGVKLYT
CCEEEEECCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCEEEEE
YSQEEGDFHAENIRIGNGEIFFDYVSPLGNIPNIQLGVPVSINIENGVAAMALAQMSGLT
ECCCCCCEEECEEEECCCCEEEEEHHHCCCCCCEEECCEEEEEECCCHHHHHHHHHHCCC
DEEIKRGMASFRGVDRRFDFKIKNDKVVFLSDYAHHPSEIKQSILSMRALYRDKKLTAVF
HHHHHHHHHHHCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEE
QPHLYTRTRDFYKDFADSLSLLDEVILVDIYPAREQPIPGVTSKLIYDHLRPGIEKSMCK
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHH
KEEILDVLSKKDIEVLITLGAGDIDNYVPQICGLLNKK
HHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA