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The map label for this gene is mip [H]

Identifier: 150003735

GI number: 150003735

Start: 1582808

End: 1583209

Strand: Direct

Name: mip [H]

Synonym: BVU_1166

Alternate gene names: 150003735

Gene position: 1582808-1583209 (Clockwise)

Preceding gene: 150003734

Following gene: 150003737

Centisome position: 30.66

GC content: 41.29

Gene sequence:

>402_bases
ATGGGGAGAAAAGAAGAATATAAGGAAAAGAACTTGCAATATTTGCAAGTTCTTTCTACACAGGAAGGTATTTGTCCTTT
ACCTTGTAATATGTTTTATAAAGTATTGCAGACAGGTACGGGTACAGTTTCACCTACAATCCGAAGTATTGTCACCGTTC
ATTATCGGGGAAGTCTGATAAACGGAAAAGAGTTTGATAATTCCTATGACCGTAACTGTCCCGAAGCTTTCCGGCTGTGT
GATGTCATAGAGGGATGGCAGCTGGCGCTTCAACGTATGCATGTAGGAGATAAATGGGTGGTTTATATTCCTTATACTAT
GGGATATGGCAACCGTACAAGCGGGCCGATTCCTGCTTTCTCTACATTAATATTTGAGGTGGAACTGCTGGGCATTGCAT
AA

Upstream 100 bases:

>100_bases
TGGTGGTCTTTGATCGTGGGAATCATCGTATCGGTGATTTTGTCCATGTACGCATTACTGAAGCCAGTTCGGCTACATTG
AAAGGAGAAGAGGTGTTCTG

Downstream 100 bases:

>100_bases
TGCCTCCGGTTATCGGTTATGCAGTCTGTCATTCATCCGGTCTTCGTAACCGTCACGATATTTCTTTTCGGGCATAACAA
TCCATAAGATTATATAGACA

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Macrophage infectivity potentiator; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase [H]

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MGRKEEYKEKNLQYLQVLSTQEGICPLPCNMFYKVLQTGTGTVSPTIRSIVTVHYRGSLINGKEFDNSYDRNCPEAFRLC
DVIEGWQLALQRMHVGDKWVVYIPYTMGYGNRTSGPIPAFSTLIFEVELLGIA

Sequences:

>Translated_133_residues
MGRKEEYKEKNLQYLQVLSTQEGICPLPCNMFYKVLQTGTGTVSPTIRSIVTVHYRGSLINGKEFDNSYDRNCPEAFRLC
DVIEGWQLALQRMHVGDKWVVYIPYTMGYGNRTSGPIPAFSTLIFEVELLGIA
>Mature_132_residues
GRKEEYKEKNLQYLQVLSTQEGICPLPCNMFYKVLQTGTGTVSPTIRSIVTVHYRGSLINGKEFDNSYDRNCPEAFRLCD
VIEGWQLALQRMHVGDKWVVYIPYTMGYGNRTSGPIPAFSTLIFEVELLGIA

Specific function: Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI224809329, Length=99, Percent_Identity=41.4141414141414, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI224809327, Length=99, Percent_Identity=41.4141414141414, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI4758384, Length=99, Percent_Identity=41.4141414141414, Blast_Score=70, Evalue=4e-13,
Organism=Homo sapiens, GI224809331, Length=99, Percent_Identity=41.4141414141414, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI206725530, Length=87, Percent_Identity=44.8275862068966, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI17149844, Length=87, Percent_Identity=44.8275862068966, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI17149842, Length=87, Percent_Identity=44.8275862068966, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI4503729, Length=99, Percent_Identity=40.4040404040404, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI17149836, Length=100, Percent_Identity=39, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI4503725, Length=100, Percent_Identity=39, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082390, Length=131, Percent_Identity=40.4580152671756, Blast_Score=96, Evalue=1e-21,
Organism=Escherichia coli, GI1789745, Length=123, Percent_Identity=39.0243902439024, Blast_Score=88, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71993519, Length=102, Percent_Identity=42.156862745098, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=99, Percent_Identity=43.4343434343434, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17540882, Length=83, Percent_Identity=44.578313253012, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=106, Percent_Identity=38.6792452830189, Blast_Score=74, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320727, Length=86, Percent_Identity=44.1860465116279, Blast_Score=65, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281363946, Length=87, Percent_Identity=44.8275862068966, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17352457, Length=87, Percent_Identity=44.8275862068966, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24583150, Length=101, Percent_Identity=38.6138613861386, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24655568, Length=100, Percent_Identity=39, Blast_Score=66, Evalue=7e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008104
- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15118; Mature: 14986

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKEEYKEKNLQYLQVLSTQEGICPLPCNMFYKVLQTGTGTVSPTIRSIVTVHYRGSLI
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHEEHEECCCCC
NGKEFDNSYDRNCPEAFRLCDVIEGWQLALQRMHVGDKWVVYIPYTMGYGNRTSGPIPAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHH
STLIFEVELLGIA
HHHHHHHEEEECC
>Mature Secondary Structure 
GRKEEYKEKNLQYLQVLSTQEGICPLPCNMFYKVLQTGTGTVSPTIRSIVTVHYRGSLI
CCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHEEHEECCCCC
NGKEFDNSYDRNCPEAFRLCDVIEGWQLALQRMHVGDKWVVYIPYTMGYGNRTSGPIPAF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCHH
STLIFEVELLGIA
HHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1840577 [H]