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The map label for this gene is kbl [C]

Identifier: 150003559

GI number: 150003559

Start: 1304415

End: 1305605

Strand: Reverse

Name: kbl [C]

Synonym: BVU_0988

Alternate gene names: 150003559

Gene position: 1305605-1304415 (Counterclockwise)

Preceding gene: 150003562

Following gene: 150003558

Centisome position: 25.29

GC content: 43.32

Gene sequence:

>1191_bases
ATGTATGGTAAAATGAAGGAGTTCCTTGCGAAGGAACTGGCTGATATTAAGGCAGCCGGATTGTATAAAAATGAACGTAT
AATTACCACACCTCAGCGTGCGGACATCAAGGTGAATGACGGAGAAGATGTGTTGAACTTTTGTGCCAACAATTATTTAG
GTTTGTCAGATAATCAACGCTTGATCAATGCTGCCAAAGAGGCGATGGACACACATGGCTTCGGTATGTCTTCCGTACGC
TTTATCTGTGGAACTCAGGATTTGCACAAACAGCTGGAAGCTGCCATTTCTGATTATTTTAAAACAGAAGATACTATACT
TTATGCAGCTTGTTTTGATGCTAACGGTGGTTTGTTCGAACCGCTGTTTACAGAAGAAGACGCTATTATTTCAGATGCGT
TGAATCATGCATCTATTATAGATGGTGTACGCTTGTGTAAGGCAAAACGCTATCGTTATGCCAATGCTGATATGGCTGAC
CTGGAACGTTGTTTGCAGGAAGCGCAGGCACAGCGTCATCGTATTATTGCTACAGATGGTGTATTCTCGATGGATGGTAA
TGTGGCTCCATTGGATAAGATTTGTGAACTGGCGGAAAAGTATGACGCGTTGGTTATGGTGGATGAATCTCATTCGGCCG
GTGTAGTAGGTCCTACAGGGCATGGCGTGGCAGAACAGTTTAATGCATACGGGCGTGTGGATATCTTTACTGGTACATTA
GGTAAAGCATTTGGTGGGGCAATGGGAGGATTTACCACCGGTAAGAAAGAAATTATTGATATGTTGCGCCAGCGTTCCCG
TCCTTATTTATTCTCTAATTCTGTAGCTCCTGCCATTATCGGTGCTAGTCTGGAAATGTTTAAGATATTGAAAGAAAGTG
ATGCTTTGCATACTAAGCTGATGGATAATGTGAATTATTTCCGTGACAGGATGCTGGCTGCCGGTTTTGACATCAAACCA
ACTCAGAGCGCGATTTGTGCTGTGATGCTTTATGATGCGAAACTGTCTCAGGATTTTGCCGCCAAGATGCAGAAAGAGGG
CATATATGTAACCGGTTTCTATTATCCGGTTGTTCCGAAAGGACAGGCACGTATCCGTGTCCAGTTGTCTGCCGGGCATG
AAAAGGCACATTTGGATAAGGCAATTGCTGCATTTATTAAAGTGGGCAAAGAACTTGGGGTGATTAAATAA

Upstream 100 bases:

>100_bases
TTTCTCTATAATTTAATCGGATATCAAAAAAAAATAAGAACTTTGTCAAGTCAGACTGATTTTTAAACTTAAACTATATA
CTTAATAAAAAAACAAAGCT

Downstream 100 bases:

>100_bases
GCAGATTTGAAAACTATCCAGTAAAATAAGAGCAGTAAACGGTTGTATAACAATTGTTTACTGCTCTTTGTAGCCCCGAG
GGGAATCGAACCCCTATCTA

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MYGKMKEFLAKELADIKAAGLYKNERIITTPQRADIKVNDGEDVLNFCANNYLGLSDNQRLINAAKEAMDTHGFGMSSVR
FICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFEPLFTEEDAIISDALNHASIIDGVRLCKAKRYRYANADMAD
LERCLQEAQAQRHRIIATDGVFSMDGNVAPLDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFNAYGRVDIFTGTL
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIIGASLEMFKILKESDALHTKLMDNVNYFRDRMLAAGFDIKP
TQSAICAVMLYDAKLSQDFAAKMQKEGIYVTGFYYPVVPKGQARIRVQLSAGHEKAHLDKAIAAFIKVGKELGVIK

Sequences:

>Translated_396_residues
MYGKMKEFLAKELADIKAAGLYKNERIITTPQRADIKVNDGEDVLNFCANNYLGLSDNQRLINAAKEAMDTHGFGMSSVR
FICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFEPLFTEEDAIISDALNHASIIDGVRLCKAKRYRYANADMAD
LERCLQEAQAQRHRIIATDGVFSMDGNVAPLDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFNAYGRVDIFTGTL
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIIGASLEMFKILKESDALHTKLMDNVNYFRDRMLAAGFDIKP
TQSAICAVMLYDAKLSQDFAAKMQKEGIYVTGFYYPVVPKGQARIRVQLSAGHEKAHLDKAIAAFIKVGKELGVIK
>Mature_396_residues
MYGKMKEFLAKELADIKAAGLYKNERIITTPQRADIKVNDGEDVLNFCANNYLGLSDNQRLINAAKEAMDTHGFGMSSVR
FICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFEPLFTEEDAIISDALNHASIIDGVRLCKAKRYRYANADMAD
LERCLQEAQAQRHRIIATDGVFSMDGNVAPLDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFNAYGRVDIFTGTL
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIIGASLEMFKILKESDALHTKLMDNVNYFRDRMLAAGFDIKP
TQSAICAVMLYDAKLSQDFAAKMQKEGIYVTGFYYPVVPKGQARIRVQLSAGHEKAHLDKAIAAFIKVGKELGVIK

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=393, Percent_Identity=52.1628498727735, Blast_Score=428, Evalue=1e-120,
Organism=Homo sapiens, GI284448556, Length=421, Percent_Identity=49.1686460807601, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI83977442, Length=363, Percent_Identity=32.2314049586777, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI83977440, Length=363, Percent_Identity=32.2314049586777, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI83977444, Length=363, Percent_Identity=32.2314049586777, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4502025, Length=356, Percent_Identity=31.1797752808989, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI40316939, Length=356, Percent_Identity=31.1797752808989, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI119220554, Length=374, Percent_Identity=32.3529411764706, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=32.967032967033, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI5454084, Length=290, Percent_Identity=28.9655172413793, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1790046, Length=397, Percent_Identity=60.2015113350126, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=29.6829971181556, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=392, Percent_Identity=58.1632653061224, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI32566772, Length=371, Percent_Identity=31.266846361186, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17560914, Length=358, Percent_Identity=29.0502793296089, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560912, Length=358, Percent_Identity=29.0502793296089, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=292, Percent_Identity=28.7671232876712, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71982625, Length=292, Percent_Identity=28.7671232876712, Blast_Score=117, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320438, Length=378, Percent_Identity=29.8941798941799, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=29.3478260869565, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=269, Percent_Identity=29.368029739777, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24662918, Length=394, Percent_Identity=55.0761421319797, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI17137420, Length=350, Percent_Identity=30, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=31.3513513513514, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24653280, Length=284, Percent_Identity=27.8169014084507, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653276, Length=284, Percent_Identity=27.8169014084507, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653278, Length=284, Percent_Identity=27.8169014084507, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43566; Mature: 43566

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGKMKEFLAKELADIKAAGLYKNERIITTPQRADIKVNDGEDVLNFCANNYLGLSDNQR
CCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEECCCHHHHHHHHCCCCCCCCCHH
LINAAKEAMDTHGFGMSSVRFICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFE
HHHHHHHHHHHCCCCHHHHHEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PLFTEEDAIISDALNHASIIDGVRLCKAKRYRYANADMADLERCLQEAQAQRHRIIATDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECC
VFSMDGNVAPLDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFNAYGRVDIFTGTL
EEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCCEEEEECCH
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIIGASLEMFKILKESDALHTKL
HHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
MDNVNYFRDRMLAAGFDIKPTQSAICAVMLYDAKLSQDFAAKMQKEGIYVTGFYYPVVPK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCC
GQARIRVQLSAGHEKAHLDKAIAAFIKVGKELGVIK
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYGKMKEFLAKELADIKAAGLYKNERIITTPQRADIKVNDGEDVLNFCANNYLGLSDNQR
CCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEEECCCHHHHHHHHCCCCCCCCCHH
LINAAKEAMDTHGFGMSSVRFICGTQDLHKQLEAAISDYFKTEDTILYAACFDANGGLFE
HHHHHHHHHHHCCCCHHHHHEEECCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PLFTEEDAIISDALNHASIIDGVRLCKAKRYRYANADMADLERCLQEAQAQRHRIIATDG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCEEEEECC
VFSMDGNVAPLDKICELAEKYDALVMVDESHSAGVVGPTGHGVAEQFNAYGRVDIFTGTL
EEECCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCHHHHHCCCCCEEEEECCH
GKAFGGAMGGFTTGKKEIIDMLRQRSRPYLFSNSVAPAIIGASLEMFKILKESDALHTKL
HHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
MDNVNYFRDRMLAAGFDIKPTQSAICAVMLYDAKLSQDFAAKMQKEGIYVTGFYYPVVPK
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCC
GQARIRVQLSAGHEKAHLDKAIAAFIKVGKELGVIK
CCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]