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The map label for this gene is mutS [H]

Identifier: 150003358

GI number: 150003358

Start: 1083492

End: 1085291

Strand: Direct

Name: mutS [H]

Synonym: BVU_0776

Alternate gene names: 150003358

Gene position: 1083492-1085291 (Clockwise)

Preceding gene: 150003356

Following gene: 150003405

Centisome position: 20.98

GC content: 47.33

Gene sequence:

>1800_bases
ATGGAATTGAAAGCAAAATACGAACAGCGCATTGAACAGGCTGAGGCAGAACTCCGCCAGATAAAAAATAAGATTCTCCG
CATCAGCACGCTGAGGGTCTTGTTATTTGCAGCAGGGATTATAGGAACAATCTACTTCTATCAGGCAGGGACACCCACTA
TATGTCTAACCATAGCGGTCACTTTCGTTCCTTTTCTGGCATTGGTGAAGTATCACAACCGGTTGTTTTTCCGCAAAGAC
TGGCTGGAAACCTGCATACGGGTGAATAGTGACGAGCTTTCCGCACTGGCGGACAACTATGAGCCTTTTGAGGACGGAAA
GGAATTCACAAACCCGGCCCACAGGTATTCTTTTGACCTGGACTTGTTCGGAAGGCACTCCTTGTTCCAGGCCTTGAACC
GTACCTGCACTTCATTCGGAAAGGAAAAACTGGCAGAATGGTTGCAAAATCATCTGGAGATAAAGGAAGAGATAATCCAA
CGGCAGGAGGCGACAAAGGAACTGGCTGCTTATTCCGATTTCCGGGAAACATTCCGGATCACCGGCCTGCTCTACAAAGG
GGCGACAAGCGACCGCGAAGAAATTAAAGAGTGGACGGAAGCACCTGCCTATTTCAGCAAGAAATGGTGGAGCCGCCCGT
TATTGGGAATCGTTCCCGGAGTCAACATCGTACTGGCTATGCTGGGAGTGGCGGGGGTCATTCCGATGACATGGTTCGGA
CTGGCCTTCGGACTGTTCGTGATAGGTAGTTTCGGACTGATAAAGCCTGTCAGCAACCTGCAAAGAGTGTATGACAAGAA
ATTACGTATCCTGTCTATCTACGCCGAACTGATCAGCCTGATAGAAAACCGGGAAATGAACGCTCCGCTACTCAGACACC
TGAAAGCTGAATTCGGCATGAACGGGAAATCCACCACCCATATCTTGAAAGAGCTTTCACGGGAACTGGACAAACTGGAC
TTGCGCAACAACCAACTGCTATATGTCTTGCTGGAAGGTTCCATGTTCTGGCAACTCCGGCAGGTAATGCGCATTGAGCA
ATGGAGGCACAAATATGGAAAATATCTGCTCCACTGGCTGGACGTATTGGGTGACATTGATGCTCTTTGTTCTCTGGCGA
CATTTGCCGGCAACCATCCCGCATACACCTATCCGACCATTGCCGGCAAGCCTTTTGTATTCCTTGCAAAGGATATGGGA
CATCCCCTGATGCCTGCACGGCAATGTGTGACCAATGATGCCGATATCCCCTCAAGACCGTTCTTTGTCATCATCACAGG
AGCCAACATGGCAGGAAAAAGTACTTATCTGCGTACAATCGGAGTGAATTATGTATTGGCATGTACCGGCTGCCCCGTAT
GCTGTTCCTCCCTTGAAATATATCCTGCCAAACTAGTGACAAGCTTGCGGACTTCCGATTCGTTGACAGACAACGAATCT
TACTTCTTTGCCGAACTAAAACGATTGAAACAAATTATAGACCGCCTGAATAAGGGAGAGGAGTTGTTCATCATTCTGGA
TGAGATTTTAAAAGGAACCAACTCGATGGACAAGCAGAAAGGCTCATTCGCCCTGGTACGCCAACTGATGGAACTGAAGA
CGAATGGCATCATTGCCACACACGACCTGCTATTAGGGAAACTAATAGAATATTTCCCCAAAGAGATACGGAATTATTGC
TTTGAAGCTGATATTACCAACGATGAACTGACTTTTTCATACAAACTCCGTGAAGGTATCGCACAAAATATGAATGCCTG
CTTCCTGATGAAAAAGATGGGGCTAATCATCAACGACTAA

Upstream 100 bases:

>100_bases
AAAGTTCTTCGCCATACCCTTGCATCGCCGCAGAAGGCTTCCCCCTCTCCGCTGCAAAACCGCGCCCGGTATGGCAAGGA
AATATTTATAACCTATCATT

Downstream 100 bases:

>100_bases
CCCCACCCGACAATTTATCACATTAACGTCTTAAGCAAATAAAGCAGACCTTCACAGGCACACCTTATTTCATAACATAA
AGAGTCATAGAAAATCAAAA

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MELKAKYEQRIEQAEAELRQIKNKILRISTLRVLLFAAGIIGTIYFYQAGTPTICLTIAVTFVPFLALVKYHNRLFFRKD
WLETCIRVNSDELSALADNYEPFEDGKEFTNPAHRYSFDLDLFGRHSLFQALNRTCTSFGKEKLAEWLQNHLEIKEEIIQ
RQEATKELAAYSDFRETFRITGLLYKGATSDREEIKEWTEAPAYFSKKWWSRPLLGIVPGVNIVLAMLGVAGVIPMTWFG
LAFGLFVIGSFGLIKPVSNLQRVYDKKLRILSIYAELISLIENREMNAPLLRHLKAEFGMNGKSTTHILKELSRELDKLD
LRNNQLLYVLLEGSMFWQLRQVMRIEQWRHKYGKYLLHWLDVLGDIDALCSLATFAGNHPAYTYPTIAGKPFVFLAKDMG
HPLMPARQCVTNDADIPSRPFFVIITGANMAGKSTYLRTIGVNYVLACTGCPVCCSSLEIYPAKLVTSLRTSDSLTDNES
YFFAELKRLKQIIDRLNKGEELFIILDEILKGTNSMDKQKGSFALVRQLMELKTNGIIATHDLLLGKLIEYFPKEIRNYC
FEADITNDELTFSYKLREGIAQNMNACFLMKKMGLIIND

Sequences:

>Translated_599_residues
MELKAKYEQRIEQAEAELRQIKNKILRISTLRVLLFAAGIIGTIYFYQAGTPTICLTIAVTFVPFLALVKYHNRLFFRKD
WLETCIRVNSDELSALADNYEPFEDGKEFTNPAHRYSFDLDLFGRHSLFQALNRTCTSFGKEKLAEWLQNHLEIKEEIIQ
RQEATKELAAYSDFRETFRITGLLYKGATSDREEIKEWTEAPAYFSKKWWSRPLLGIVPGVNIVLAMLGVAGVIPMTWFG
LAFGLFVIGSFGLIKPVSNLQRVYDKKLRILSIYAELISLIENREMNAPLLRHLKAEFGMNGKSTTHILKELSRELDKLD
LRNNQLLYVLLEGSMFWQLRQVMRIEQWRHKYGKYLLHWLDVLGDIDALCSLATFAGNHPAYTYPTIAGKPFVFLAKDMG
HPLMPARQCVTNDADIPSRPFFVIITGANMAGKSTYLRTIGVNYVLACTGCPVCCSSLEIYPAKLVTSLRTSDSLTDNES
YFFAELKRLKQIIDRLNKGEELFIILDEILKGTNSMDKQKGSFALVRQLMELKTNGIIATHDLLLGKLIEYFPKEIRNYC
FEADITNDELTFSYKLREGIAQNMNACFLMKKMGLIIND
>Mature_599_residues
MELKAKYEQRIEQAEAELRQIKNKILRISTLRVLLFAAGIIGTIYFYQAGTPTICLTIAVTFVPFLALVKYHNRLFFRKD
WLETCIRVNSDELSALADNYEPFEDGKEFTNPAHRYSFDLDLFGRHSLFQALNRTCTSFGKEKLAEWLQNHLEIKEEIIQ
RQEATKELAAYSDFRETFRITGLLYKGATSDREEIKEWTEAPAYFSKKWWSRPLLGIVPGVNIVLAMLGVAGVIPMTWFG
LAFGLFVIGSFGLIKPVSNLQRVYDKKLRILSIYAELISLIENREMNAPLLRHLKAEFGMNGKSTTHILKELSRELDKLD
LRNNQLLYVLLEGSMFWQLRQVMRIEQWRHKYGKYLLHWLDVLGDIDALCSLATFAGNHPAYTYPTIAGKPFVFLAKDMG
HPLMPARQCVTNDADIPSRPFFVIITGANMAGKSTYLRTIGVNYVLACTGCPVCCSSLEIYPAKLVTSLRTSDSLTDNES
YFFAELKRLKQIIDRLNKGEELFIILDEILKGTNSMDKQKGSFALVRQLMELKTNGIIATHDLLLGKLIEYFPKEIRNYC
FEADITNDELTFSYKLREGIAQNMNACFLMKKMGLIIND

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=240, Percent_Identity=28.75, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4557761, Length=171, Percent_Identity=32.7485380116959, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI4504191, Length=174, Percent_Identity=28.735632183908, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1789089, Length=225, Percent_Identity=28, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17534743, Length=229, Percent_Identity=29.6943231441048, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17508445, Length=229, Percent_Identity=31.4410480349345, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319935, Length=252, Percent_Identity=29.3650793650794, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320302, Length=200, Percent_Identity=28.5, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=196, Percent_Identity=29.0816326530612, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664545, Length=544, Percent_Identity=21.875, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24584320, Length=230, Percent_Identity=27.3913043478261, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 68629; Mature: 68629

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKAKYEQRIEQAEAELRQIKNKILRISTLRVLLFAAGIIGTIYFYQAGTPTICLTIAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
TFVPFLALVKYHNRLFFRKDWLETCIRVNSDELSALADNYEPFEDGKEFTNPAHRYSFDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHCCCHHHEEECH
DLFGRHSLFQALNRTCTSFGKEKLAEWLQNHLEIKEEIIQRQEATKELAAYSDFRETFRI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLLYKGATSDREEIKEWTEAPAYFSKKWWSRPLLGIVPGVNIVLAMLGVAGVIPMTWFG
HHHEECCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
LAFGLFVIGSFGLIKPVSNLQRVYDKKLRILSIYAELISLIENREMNAPLLRHLKAEFGM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
NGKSTTHILKELSRELDKLDLRNNQLLYVLLEGSMFWQLRQVMRIEQWRHKYGKYLLHWL
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVLGDIDALCSLATFAGNHPAYTYPTIAGKPFVFLAKDMGHPLMPARQCVTNDADIPSRP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHCCCCCCHHHHHHCCCCCCCCCC
FFVIITGANMAGKSTYLRTIGVNYVLACTGCPVCCSSLEIYPAKLVTSLRTSDSLTDNES
EEEEEECCCCCCCHHHHHHHCCCEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCH
YFFAELKRLKQIIDRLNKGEELFIILDEILKGTNSMDKQKGSFALVRQLMELKTNGIIAT
HHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCHHCCCHHHHHHHHHHHHCCCEEEH
HDLLLGKLIEYFPKEIRNYCFEADITNDELTFSYKLREGIAQNMNACFLMKKMGLIIND
HHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEHHHHHHHHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MELKAKYEQRIEQAEAELRQIKNKILRISTLRVLLFAAGIIGTIYFYQAGTPTICLTIAV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
TFVPFLALVKYHNRLFFRKDWLETCIRVNSDELSALADNYEPFEDGKEFTNPAHRYSFDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHCCCHHHEEECH
DLFGRHSLFQALNRTCTSFGKEKLAEWLQNHLEIKEEIIQRQEATKELAAYSDFRETFRI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLLYKGATSDREEIKEWTEAPAYFSKKWWSRPLLGIVPGVNIVLAMLGVAGVIPMTWFG
HHHEECCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHH
LAFGLFVIGSFGLIKPVSNLQRVYDKKLRILSIYAELISLIENREMNAPLLRHLKAEFGM
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
NGKSTTHILKELSRELDKLDLRNNQLLYVLLEGSMFWQLRQVMRIEQWRHKYGKYLLHWL
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVLGDIDALCSLATFAGNHPAYTYPTIAGKPFVFLAKDMGHPLMPARQCVTNDADIPSRP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHCCCCCCHHHHHHCCCCCCCCCC
FFVIITGANMAGKSTYLRTIGVNYVLACTGCPVCCSSLEIYPAKLVTSLRTSDSLTDNES
EEEEEECCCCCCCHHHHHHHCCCEEEEECCCHHHHHCCHHHHHHHHHHHHCCCCCCCCCH
YFFAELKRLKQIIDRLNKGEELFIILDEILKGTNSMDKQKGSFALVRQLMELKTNGIIAT
HHHHHHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCHHCCCHHHHHHHHHHHHCCCEEEH
HDLLLGKLIEYFPKEIRNYCFEADITNDELTFSYKLREGIAQNMNACFLMKKMGLIIND
HHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEHHHHHHHHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA