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The map label for this gene is serC [H]

Identifier: 148828321

GI number: 148828321

Start: 1766446

End: 1767534

Strand: Reverse

Name: serC [H]

Synonym: CGSHiGG_09535

Alternate gene names: 148828321

Gene position: 1767534-1766446 (Counterclockwise)

Preceding gene: 148828323

Following gene: 148828319

Centisome position: 93.66

GC content: 38.75

Gene sequence:

>1089_bases
ATGTCACAAGTCTTTAATTTTAGCGCAGGTCCTGCGATGATTTTCCCAGAAGTGTTGCAAAAAGCACAAAATGAACTTAC
AAACTGGCTCAATCAAGGTGTGTCCGTAATGGAAGTAAGCCATCGAGGAAAGTATTTTATGGAACTCGTTACCCAAGCGG
AAAAAGATCTACGTGAGGTTTACAATATTCCTGATAACTATCGTGTACTTTTCTTACAAGGTGGCGCTCGCGGTCAATTT
GCCGCGATTCCGATGAACTTAATCGGTAAAAAAGGCAAAGCCCTTTATTTAAATAGTGGGCATTGGTCAGCTACAGCAGC
AAAAGAAGCAAGAAATTTTGCAGAAATTGATGAAATCACTATCGTAGAAAATGGCGAACAGACTCGAATTACCGATCTTG
ATTTTAGCCATATCGCTGATCAATATGACTACGTTCATTATTGCCCGAATGAAACCATCAGTGGTGTGGAGATTTTTGAT
GTTCCAAATGTAGGCAATGCCGTATTGGTCGCGGATATGTCTTCAAATATTCTTTCACGTCAAATCGATATCAGTAAATT
TGGGGTAATTTATGCTGGTGCACAAAAAAATCTTGGCCCTGCGGGCATTACATTAGTCATTATTCGTGATGATTTAATCG
GTAATGCACGTAAAGAAACCCCATCTATTTGGAATTATGCAACTCAACGTGATGCAGATTCAATGATCAACACGCCCCCA
ACTTTTGCGTGGTATTTATGTTCCCTCGTATTTAAACATCTTAAAGAAATAGGCGGCTTAGAAATAATCGAAAAACGTAA
TGCACTAAAAGCACAAACCCTTTATGATTATATTGATTCGAGCAAACTTTACCGCAATGTAGTAGCAAAAGAAAACCGCT
CAACAATGAATGTCACTTTCATCACAGGTAATCCTGAATTAGATGCAAAATTTGTCGCAGAATCTACTGCTGCTGGCTTG
CAAGCCTTGAAAGGTCATAAGGTTTTAGGTGGAATGCGCGCATCTATTTATAACGCAATGTCGCAAAATGGTGTTGAGGC
ACTCATTTCATTTATGAAAAAATTTGAAACTGAAAATCTTCCTCAATAG

Upstream 100 bases:

>100_bases
GATAGAAAGAATTTTTTTGATTTCAGTAAAAAGCATTGATTATCGATTTTTGTAGTGATAAAAAAGACATCATTATTTTC
ATAAAAACCAAGGAAATACA

Downstream 100 bases:

>100_bases
GAAAAACATTTCCAATGGGCGTATTTACTACGCCCAAATTTATTTAAAAATACATACTAACCCATATCAATATTTACAAA
TAACACTATGCAGTACATCA

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRVLFLQGGARGQF
AAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFD
VPNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTAAGL
QALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ

Sequences:

>Translated_362_residues
MSQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRVLFLQGGARGQF
AAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFD
VPNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTAAGL
QALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ
>Mature_361_residues
SQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREVYNIPDNYRVLFLQGGARGQFA
AIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEITIVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDV
PNVGNAVLVADMSSNILSRQIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPPT
FAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTFITGNPELDAKFVAESTAAGLQ
ALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENLPQ

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=360, Percent_Identity=46.1111111111111, Blast_Score=318, Evalue=3e-87,
Organism=Homo sapiens, GI10863955, Length=355, Percent_Identity=42.2535211267606, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=53.7604456824513, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17506897, Length=357, Percent_Identity=42.8571428571429, Blast_Score=277, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6324758, Length=385, Percent_Identity=38.7012987012987, Blast_Score=241, Evalue=9e-65,
Organism=Drosophila melanogaster, GI21356589, Length=362, Percent_Identity=45.3038674033149, Blast_Score=303, Evalue=2e-82,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 40269; Mature: 40138

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
YNIPDNYRVLFLQGGARGQFAAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEIT
HCCCCCCEEEEEECCCCCCEEEECHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEE
IVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDVPNVGNAVLVADMSSNILSR
EEECCCCCEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCHHHHH
QIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
HCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHCCCCC
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTF
HHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ITGNPELDAKFVAESTAAGLQALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENL
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PQ
CC
>Mature Secondary Structure 
SQVFNFSAGPAMIFPEVLQKAQNELTNWLNQGVSVMEVSHRGKYFMELVTQAEKDLREV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHH
YNIPDNYRVLFLQGGARGQFAAIPMNLIGKKGKALYLNSGHWSATAAKEARNFAEIDEIT
HCCCCCCEEEEEECCCCCCEEEECHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCEE
IVENGEQTRITDLDFSHIADQYDYVHYCPNETISGVEIFDVPNVGNAVLVADMSSNILSR
EEECCCCCEEECCCHHHHHHHCCEEEECCCCCCCCEEEEECCCCCCEEEEEECCCHHHHH
QIDISKFGVIYAGAQKNLGPAGITLVIIRDDLIGNARKETPSIWNYATQRDADSMINTPP
HCCHHHCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHCCCCC
TFAWYLCSLVFKHLKEIGGLEIIEKRNALKAQTLYDYIDSSKLYRNVVAKENRSTMNVTF
HHHHHHHHHHHHHHHHCCCEEEEHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ITGNPELDAKFVAESTAAGLQALKGHKVLGGMRASIYNAMSQNGVEALISFMKKFETENL
EECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCC
PQ
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]