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The map label for this gene is hpt [H]

Identifier: 148828311

GI number: 148828311

Start: 1749791

End: 1750330

Strand: Direct

Name: hpt [H]

Synonym: CGSHiGG_09435

Alternate gene names: 148828311

Gene position: 1749791-1750330 (Clockwise)

Preceding gene: 148828305

Following gene: 148828312

Centisome position: 92.72

GC content: 37.78

Gene sequence:

>540_bases
ATGAAAAAACACCACGTAGATGTTTTAATTTCAGAGAACGATGTTCATGCTCGTATTGCTGAATTAGGTTCTCAAATCAC
AAAATTTTATCAAGAAAAACAGATCGATAGCCTTGTTGTCGTAGGACTTTTACGTGGTTCCTTTATGTTTATGGCGGATA
TCGTTCGTCAGATAAATTTACCTGTGGAAATTGAATTTATGACTACTTCAAGTTATGGCACTGGCATGACCACGAATCAC
GACGTTCGTATTACCAAAGATTTGGACGGCGATATAAAAGGTAAACACGTTTTAATTGTGGAAGATATTATTGATACGGG
TTATACGTTGGAAAAAGTGCGTGATATTTTGAATTTACGTGAGCCTGCGAGCCTTGCAATTTGTACGTTACTTGATAAGC
CTTCTCGTCGGGAAGTGGAAGTGCTTGTTGAATGGGTTGGTTTTGAAATTCCTGATGAATTTGTTGTGGGGTATGGTATC
GATTACGCGCAACGCCATCGTAATTTAGGCTATATCGGTAAAGTTGTTTTAGAAGAATAA

Upstream 100 bases:

>100_bases
AAATTCGTTAGGGTTCAAAAAGGCTGAAGGTTTAAACTTCAGCCTTTTTTTTGTAAAATAGCAAACGATTTTATCCCCTG
TCATTTCATAAGGAAACACA

Downstream 100 bases:

>100_bases
TTTGATTTTATTGAAAAGTGCGGTTGAAATTTTAAATGAATTTTTAGCCGCACTTTTTTATATTATTTCATTGCTATTTT
CTCGATCACTTGCTAAATCT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKKHHVDVLISENDVHARIAELGSQITKFYQEKQIDSLVVVGLLRGSFMFMADIVRQINLPVEIEFMTTSSYGTGMTTNH
DVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLREPASLAICTLLDKPSRREVEVLVEWVGFEIPDEFVVGYGI
DYAQRHRNLGYIGKVVLEE

Sequences:

>Translated_179_residues
MKKHHVDVLISENDVHARIAELGSQITKFYQEKQIDSLVVVGLLRGSFMFMADIVRQINLPVEIEFMTTSSYGTGMTTNH
DVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLREPASLAICTLLDKPSRREVEVLVEWVGFEIPDEFVVGYGI
DYAQRHRNLGYIGKVVLEE
>Mature_179_residues
MKKHHVDVLISENDVHARIAELGSQITKFYQEKQIDSLVVVGLLRGSFMFMADIVRQINLPVEIEFMTTSSYGTGMTTNH
DVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLREPASLAICTLLDKPSRREVEVLVEWVGFEIPDEFVVGYGI
DYAQRHRNLGYIGKVVLEE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=144, Percent_Identity=34.7222222222222, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI9910262, Length=174, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI87081689, Length=175, Percent_Identity=69.1428571428571, Blast_Score=247, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17510817, Length=173, Percent_Identity=36.4161849710983, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20346; Mature: 20346

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHHVDVLISENDVHARIAELGSQITKFYQEKQIDSLVVVGLLRGSFMFMADIVRQINL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
PVEIEFMTTSSYGTGMTTNHDVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLR
CEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCCC
EPASLAICTLLDKPSRREVEVLVEWVGFEIPDEFVVGYGIDYAQRHRNLGYIGKVVLEE
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHEEECCCCHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MKKHHVDVLISENDVHARIAELGSQITKFYQEKQIDSLVVVGLLRGSFMFMADIVRQINL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
PVEIEFMTTSSYGTGMTTNHDVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLR
CEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCCC
EPASLAICTLLDKPSRREVEVLVEWVGFEIPDEFVVGYGIDYAQRHRNLGYIGKVVLEE
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHEEECCCCHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]