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The map label for this gene is lpxC [H]

Identifier: 148828304

GI number: 148828304

Start: 1742090

End: 1743007

Strand: Direct

Name: lpxC [H]

Synonym: CGSHiGG_09380

Alternate gene names: 148828304

Gene position: 1742090-1743007 (Clockwise)

Preceding gene: 148828303

Following gene: 148828305

Centisome position: 92.31

GC content: 35.84

Gene sequence:

>918_bases
ATGATTAAACAAAGAACATTAAAACAAAGTATTAAAGTTACAGGCGTTGGCTTGCATAGCGGTGAAAAAGTGACATTAAC
CTTGCGCCCAGCTATGCCAAACACTGGTGTTGTTTATTATCGTACAGATTTAAACCCTACGGTGGCATTCCCTGCTGATC
CTAATTCAGTGCGTGATACAATGCTTTGTACCGCACTAATTAATGAACAAGGTGTGCGTATTTCTACCGTCGAGCATTTA
AATGCAGCTTTGGCAGGGCTTGGTATTGATAATATTATTATTGAAGTTGATGCTCCTGAAATTCCAATTATGGATGGTAG
TGCTAGTCCGTTTATCTATTTGTTGTTAGATGCGGGAATTGAAGAACAAAATGCAGCGAAAAAATTTATTCGTATTAAGG
AATATGTTCGAGTTGAAGATGGCGATAAATGGGCTGAATTTAAGCCTTACAATGGTTTTCGTTTAGATTTTACTATTGAT
TTTGACCATCCTGCTATTGGCAAAGATGTACGTAACTATGAAATGAATTTTTCTGCCCAAGCATTTGTTCATCAAATTAG
CCGAGCAAGAACTTTTGGCTTTATGAAAGATATTGAATATCTTCAATCTCAAGGTTTAGTATTAGGTGGTAGCCTTGATA
ATGCGATTGTTCTTGATGATTATAGAATTTTAAATGAAGATGGTTTACGTTTTAAAGATGAACTTGTTCGTCATAAAATG
TTAGACGCAATTGGTGATCTTTATATGGCTGGTTATAACATTATCGGTGATTTTAAAGCCTATAAATCAGGTCACGGTTT
AAATAACAAGTTACTTCGTGCTGTTTTAGCAAATCAAGAAGCGTGGGAATTTGTAACCTTTGAAGATAAAGAGCAAGTGC
CACAAGGGTATGTAGCTCCAGTGCAAGTGCTTATTTAA

Upstream 100 bases:

>100_bases
ATCGCTTGGAAGCATTTAAGAAAAATAATTTCTTTAATCCTGCACAGCGTGAAGAAAATTAATAAGTTTCAGAAAATACC
TAGTAAATGAAGGTAGTAGA

Downstream 100 bases:

>100_bases
TTGTTTTATTGTTGAAAAAGCTATATTTCTGGTGGGAAGTATAGCTTTTTTATTTCATCTCGTGCTTAAATATCGAATGT
ACTAAAAGTGCGGTCAATTT

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIKQRTLKQSIKVTGVGLHSGEKVTLTLRPAMPNTGVVYYRTDLNPTVAFPADPNSVRDTMLCTALINEQGVRISTVEHL
NAALAGLGIDNIIIEVDAPEIPIMDGSASPFIYLLLDAGIEEQNAAKKFIRIKEYVRVEDGDKWAEFKPYNGFRLDFTID
FDHPAIGKDVRNYEMNFSAQAFVHQISRARTFGFMKDIEYLQSQGLVLGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFEDKEQVPQGYVAPVQVLI

Sequences:

>Translated_305_residues
MIKQRTLKQSIKVTGVGLHSGEKVTLTLRPAMPNTGVVYYRTDLNPTVAFPADPNSVRDTMLCTALINEQGVRISTVEHL
NAALAGLGIDNIIIEVDAPEIPIMDGSASPFIYLLLDAGIEEQNAAKKFIRIKEYVRVEDGDKWAEFKPYNGFRLDFTID
FDHPAIGKDVRNYEMNFSAQAFVHQISRARTFGFMKDIEYLQSQGLVLGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFEDKEQVPQGYVAPVQVLI
>Mature_305_residues
MIKQRTLKQSIKVTGVGLHSGEKVTLTLRPAMPNTGVVYYRTDLNPTVAFPADPNSVRDTMLCTALINEQGVRISTVEHL
NAALAGLGIDNIIIEVDAPEIPIMDGSASPFIYLLLDAGIEEQNAAKKFIRIKEYVRVEDGDKWAEFKPYNGFRLDFTID
FDHPAIGKDVRNYEMNFSAQAFVHQISRARTFGFMKDIEYLQSQGLVLGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFEDKEQVPQGYVAPVQVLI

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=77.3026315789474, Blast_Score=498, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 34193; Mature: 34193

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKQRTLKQSIKVTGVGLHSGEKVTLTLRPAMPNTGVVYYRTDLNPTVAFPADPNSVRDT
CCCHHHHHHCEEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCCHHHHH
MLCTALINEQGVRISTVEHLNAALAGLGIDNIIIEVDAPEIPIMDGSASPFIYLLLDAGI
HHHHHHHCCCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCEEEEEEECCC
EEQNAAKKFIRIKEYVRVEDGDKWAEFKPYNGFRLDFTIDFDHPAIGKDVRNYEMNFSAQ
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEECCCHHH
AFVHQISRARTFGFMKDIEYLQSQGLVLGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECEEEECCCCCCHHHHHHHHHH
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFEDKEQVPQGYVAP
HHHHHHHHHHCCCEEECHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHCCCCCCCE
VQVLI
EEEEC
>Mature Secondary Structure
MIKQRTLKQSIKVTGVGLHSGEKVTLTLRPAMPNTGVVYYRTDLNPTVAFPADPNSVRDT
CCCHHHHHHCEEEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEECCCCCCHHHHH
MLCTALINEQGVRISTVEHLNAALAGLGIDNIIIEVDAPEIPIMDGSASPFIYLLLDAGI
HHHHHHHCCCCCEEEHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCCCCEEEEEEECCC
EEQNAAKKFIRIKEYVRVEDGDKWAEFKPYNGFRLDFTIDFDHPAIGKDVRNYEMNFSAQ
CHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCEECCCHHH
AFVHQISRARTFGFMKDIEYLQSQGLVLGGSLDNAIVLDDYRILNEDGLRFKDELVRHKM
HHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECEEEECCCCCCHHHHHHHHHH
LDAIGDLYMAGYNIIGDFKAYKSGHGLNNKLLRAVLANQEAWEFVTFEDKEQVPQGYVAP
HHHHHHHHHHCCCEEECHHHHCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHCCCCCCCE
VQVLI
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA