Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 148828150

GI number: 148828150

Start: 1559835

End: 1561181

Strand: Direct

Name: accC [H]

Synonym: CGSHiGG_08440

Alternate gene names: 148828150

Gene position: 1559835-1561181 (Clockwise)

Preceding gene: 148828149

Following gene: 148828151

Centisome position: 82.65

GC content: 41.65

Gene sequence:

>1347_bases
ATGTTAGAAAAAGTTGTGATTGCTAACCGCGGTGAAATTGCACTACGCATTTTACGTGCTTGTAAAGAATTAGGTATTAA
AACTGTGGCAGTTCACTCCACTGCTGATCGTGATTTAAAACACGTTTTACTCGCTGATGAAACCGTTTGTATCGGTCCAG
CACCTTCCGCAAAAAGTTATTTAAATATTCCAGCTATCATTGCTGCCGCCGAAGTAACAGGTGCGGATGCAATTCATCCT
GGATACGGTTTCTTATCTGAAAACGCTGACTTTGCTGAACAAGTTGAACGTTCAGGTTTCACTTTCATCGGCCCAACAGC
AGATGTCATCCGTTTAATGGGCGATAAAGTTTCAGCTATTAAAGCGATGAAAAAAGCAGGCGTGCCTTGTGTACCAGGTT
CGGATGGCCCTGTAAGTAATGATATTGCTAAAAATAAAGAAATCGCCAAACGTATTGGTTATCCAATCATCATCAAAGCA
TCAGGCGGCGGCGGTGGCCGAGGAATGCGTGTTGTTCGTAGCGAAGACGCATTAGAAGAATCTATCGCGATGACCAAAGC
AGAAGCGAAAGCGGCATTCAATAATGATATGGTTTATATGGAAAAATACTTAGAAAATCCACGTCACGTGGAAATTCAAG
TATTAGCAGATACCCATGGAAATGCGGTTTATTTGGCTGAACGTGACTGCTCAATGCAGCGTCGTCACCAAAAAGTTGTG
GAAGAAGCACCAGCTCCAGGTATCACAGAAGAAGTTCGCCGCGATATTGGCTCTCGCTGTGCAAATGCTTGTGTAGAAAT
CGGCTATCGCGGAGCGGGAACCTTTGAATTCTTATATGAAAATGGCGAATTCTACTTTATTGAAATGAATACCCGTATCC
AAGTAGAACACCCAGTAACAGAAATGATCACAGGTGTAGATTTAGTGAAAGAGCAATTACGCATCGCAGCAGGCTTGCCA
ATTTCCTTTAAACAAGAGGACATTAAAGTTAAAGGTCACGCAATGGAATGCCGTATTAACGCAGAAGATTCAAAAACATT
CTTACCGTCTCCGGGCAAAGTAAATCACTTACATTCGCCTGGCGGTTTGGGCGTTCGTTGGGACTCTCATGTTTATGGCG
GCTATACTGTGCCTCCACATTACGACTCGATGATCGCAAAACTTATCACTTACGGCGATACACGTGAAGTGGCAATCCGT
CGTATGCAAAATGCCTTATCTGAAACAATTATTGATGGTATTAAAACCAATATTCCACTTCATGAATTAATTCTTGAAGA
TGAAAATTTCCAAAAAGGTGGAACAAATATCCATTATTTGGAGAAAAAATTAGGTATGAATGAATAA

Upstream 100 bases:

>100_bases
GATATAAATTGAAATCTGTTCACGCCAAATTTTATAGGGAGAACAATATTTCAAGAGCCTACATAAAAATTCACGTCTAT
CTGACTAAACGGACTCTTTT

Downstream 100 bases:

>100_bases
TTAAACGTTAAATGGCTAACAAAGGTTAGCCATTTTTATATATTCCGATATTTATTTAATGATAATAAAAACTAAAACGA
GCAAAACATTTTGAATTATT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPAPSAKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKA
SGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISFKQEDIKVKGHAMECRINAEDSKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALSETIIDGIKTNIPLHELILEDENFQKGGTNIHYLEKKLGMNE

Sequences:

>Translated_448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPAPSAKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKA
SGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISFKQEDIKVKGHAMECRINAEDSKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALSETIIDGIKTNIPLHELILEDENFQKGGTNIHYLEKKLGMNE
>Mature_448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPAPSAKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKA
SGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISFKQEDIKVKGHAMECRINAEDSKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALSETIIDGIKTNIPLHELILEDENFQKGGTNIHYLEKKLGMNE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=50.9090909090909, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.7584650112867, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.7584650112867, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.7584650112867, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=45.6570155902004, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=45.6570155902004, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=45.6570155902004, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=30.5882352941176, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=30.5882352941176, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=30.5882352941176, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=30.5882352941176, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=30.5882352941176, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=31.3840155945419, Blast_Score=232, Evalue=5e-61,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=82.1428571428571, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=240, Percent_Identity=24.1666666666667, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.4040632054176, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.737556561086, Blast_Score=397, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.0892857142857, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.8387096774194, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=27.4661508704062, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=27.4661508704062, Blast_Score=197, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.6636568848758, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=439, Percent_Identity=46.9248291571754, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=439, Percent_Identity=47.1526195899772, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.2015503875969, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6323863, Length=458, Percent_Identity=33.1877729257642, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.1901565995526, Blast_Score=394, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=47.0982142857143, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.0980392156863, Blast_Score=356, Evalue=2e-98,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=30.0990099009901, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=30.0990099009901, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=30.0990099009901, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=30.0990099009901, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49085; Mature: 49085

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPAPSAKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHEEEECCEEEECCCCCCCCC
LNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAI
CCCCHHEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCHHHHHHHHCCHHHHH
KAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALEE
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRIAAGLPISFKQEDIKVKGHAMECRINAEDSKTFLPSPGKVNHLHSP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEEECCCCCEECCCCCCCCCCCCC
GGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTNIPL
CCCCEEECCEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
HELILEDENFQKGGTNIHYLEKKLGMNE
HHHHCCCCCCCCCCCCCEEHHHHCCCCC
>Mature Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETVCIGPAPSAKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHEEEECCEEEECCCCCCCCC
LNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAI
CCCCHHEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCHHHHHHHHCCHHHHH
KAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALEE
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRIAAGLPISFKQEDIKVKGHAMECRINAEDSKTFLPSPGKVNHLHSP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEEECCCCCEECCCCCCCCCCCCC
GGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTNIPL
CCCCEEECCEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
HELILEDENFQKGGTNIHYLEKKLGMNE
HHHHCCCCCCCCCCCCCEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]