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The map label for this gene is crp

Identifier: 148828134

GI number: 148828134

Start: 1545813

End: 1546487

Strand: Direct

Name: crp

Synonym: CGSHiGG_08360

Alternate gene names: 148828134

Gene position: 1545813-1546487 (Clockwise)

Preceding gene: 148828133

Following gene: 148828143

Centisome position: 81.91

GC content: 39.26

Gene sequence:

>675_bases
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAGTATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGT
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTAGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Upstream 100 bases:

>100_bases
TTCGCAATGGAATTGCGTTGATTGTATGGTCTGAATTACATGAATCCATTGACATCAAAAATAAAACGGAATTTTTGAAA
CAGGAATGTAAGGAGCAAGA

Downstream 100 bases:

>100_bases
TTTTTCATCATAATTTATTCAAAATAAAACCATCCGAAATTAATTTAGGTAGTTTTTGTTTAATTGGAAATAATATTCAA
AACATTAATTGACAATTAAT

Product: cAMP-regulatory protein

Products: NA

Alternate protein names: cAMP receptor protein; cAMP regulatory protein

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Sequences:

>Translated_224_residues
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR
>Mature_223_residues
SNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLGA
GQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQT
LMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Specific function: This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of one or more genes involved in the induction of competence

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1789756, Length=204, Percent_Identity=77.9411764705882, Blast_Score=347, Evalue=4e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CRP_HAEIN (P29281)

Other databases:

- EMBL:   M77207
- EMBL:   L42023
- PIR:   B38225
- RefSeq:   NP_439118.1
- ProteinModelPortal:   P29281
- SMR:   P29281
- GeneID:   949963
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0957
- TIGR:   HI_0957
- HOGENOM:   HBG648099
- OMA:   DEGHEMI
- ProtClustDB:   PRK11753
- BioCyc:   HINF71421:HI_0957-MONOMER
- GO:   GO:0005622
- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.60.120.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00034
- SMART:   SM00100
- SMART:   SM00419

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp; SSF51206 cNMP_binding

EC number: NA

Molecular weight: Translated: 25152; Mature: 25021

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00888 CNMP_BINDING_1; PS00889 CNMP_BINDING_2; PS50042 CNMP_BINDING_3; PS00042 HTH_CRP_1; PS51063 HTH_CRP_2

Important sites: BINDING 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKG
CCCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEEEC
SVMVSSKDDEGKEMILTYLGAGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQL
EEEEECCCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
IQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQTLMNLAKQPEAMTHPDGMQI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
KITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR
EEEHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCEEEEEECC
>Mature Secondary Structure 
SNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKG
CCHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEEEC
SVMVSSKDDEGKEMILTYLGAGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQL
EEEEECCCCCCHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHH
IQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQTLMNLAKQPEAMTHPDGMQI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEE
KITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR
EEEHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1542653; 7542800