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The map label for this gene is coaBC [H]

Identifier: 148828130

GI number: 148828130

Start: 1543190

End: 1544392

Strand: Direct

Name: coaBC [H]

Synonym: CGSHiGG_08340

Alternate gene names: 148828130

Gene position: 1543190-1544392 (Clockwise)

Preceding gene: 148828122

Following gene: 148828131

Centisome position: 81.77

GC content: 39.48

Gene sequence:

>1203_bases
ATGAATTTAAACGGAAAGCATATTGTAGTCGGCATAACTGGCGGTATTGCAGCCTATAAAACAATAGAGTTGATTCGTTT
ATTACGCAAAGCAGAAGCTGAAGTACGTGTAGTATTAACCCCAGCTGCAGCAGAATTTGTTACACCTTTGACACTTCAAG
CCATTTCTGGCAATGCTGTCGCACAATCTTTACTTGATCCTCAAGCTGAACTTGCAATGGGTCATATTGAACTTGCCAAA
TGGGCTGATGCCATTATTATTGCGCCAGCTAGTGCAGACTTTATTGCCCGTCTTACTATCGGCATGGCGAATGATTTACT
TTCAACAATTTGTCTTGCAACTGATGCGCCAATTTTTCTTGCTCCAGCAATGAATCAGCAGATGTATCACCAATCCATTA
CTCAACAAAATTTAACGACTCTTCAAACACGTGGGATTGAGCTTATCGGCCCCAATAGTGGTTTTCAAGCTTGCGGCGAT
ATGGGGAAAGGGCGTATGTCAGAACCAGAGGAAATTTTTACCGCACTTTCTGACTTTCTCTCTCAAAAACAAGATCTACA
AGGATTAAATGTTTCCATTACAGCAGGCCCAACGCGTGAGGCAATCGATCCCGTTCGTTATATTTCTAACCATAGTTCAG
GGAAAATGGGATTTGCGATTGCTGAAGCATTTGCCAAACGTGGGGCGAACGTCACGCTGATTTCAGGCCCCGTGAATTTA
ACAACACCAAAAAATGTAAATCGAATTAATGTCATCTCAGCACAAGAAATGTGGCAAGCCTCTCTTGAAAGTGCGGTGAA
AAATCAAATTTTTATTGGTTGTGCGGCTGTCGCTGATTACAGAGTAGCTGAAGTTGCAGAACAAAAAATCAAAAAATCTG
GCGATGAAATATCTATCAAATTAATTAAGAATCCCGATATTATCTCAGATGTAGGACATTTAAAAACACATCGTCCTTTT
ACTGTTGGATTTGCAGCCGAAACCCAAAATATTGATGATTATGCAAAAGATAAACTTGAACGCAAAAATCTTGATATGAT
TTGTGCCAACGATGTATCTGGCGGACAAGTTTTTAACGCTGATGAAAATGCCTTGCAGCTTTTTTGGAAAAATGGTCATA
AAAAATTATCGCTAAAATCAAAAGTAGAACTTGCCGCTGATTTAGTCAATGAAATCATCGAACGCTATCAAAAAACCTTA
TAA

Upstream 100 bases:

>100_bases
ATTCAAAATCTGCGATGCATATCGTAAAAATAGCGTTGGGCATTCAATAAAATTAAAGTAAAATAACGAAATTGTGGTTA
AGTACTAACAAGGGAAGAAA

Downstream 100 bases:

>100_bases
TTCCAACCGCACTTTTACCTAAAAATGAATTTCAAACGGAGTATTAAATGAAAAAAATTGACGTAAAAATTTTAGATTCT
CGCATTGGAAATGAATTTCC

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MNLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELAK
WADAIIIAPASADFIARLTIGMANDLLSTICLATDAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGD
MGKGRMSEPEEIFTALSDFLSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLISGPVNL
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVAEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPF
TVGFAAETQNIDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL

Sequences:

>Translated_400_residues
MNLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELAK
WADAIIIAPASADFIARLTIGMANDLLSTICLATDAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGD
MGKGRMSEPEEIFTALSDFLSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLISGPVNL
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVAEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPF
TVGFAAETQNIDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
>Mature_400_residues
MNLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAVAQSLLDPQAELAMGHIELAK
WADAIIIAPASADFIARLTIGMANDLLSTICLATDAPIFLAPAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGD
MGKGRMSEPEEIFTALSDFLSQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLISGPVNL
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVAEVAEQKIKKSGDEISIKLIKNPDIISDVGHLKTHRPF
TVGFAAETQNIDDYAKDKLERKNLDMICANDVSGGQVFNADENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=32.2751322751323, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082301, Length=403, Percent_Identity=60.7940446650124, Blast_Score=474, Evalue=1e-135,
Organism=Caenorhabditis elegans, GI17560194, Length=193, Percent_Identity=29.5336787564767, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=185, Percent_Identity=30.2702702702703, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=30.6451612903226, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43338; Mature: 43338

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEECCCHHH
AQSLLDPQAELAMGHIELAKWADAIIIAPASADFIARLTIGMANDLLSTICLATDAPIFL
HHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGDMGKGRMSEPEEIFTALSDFL
ECCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
SQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLISGPVNL
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCEEE
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVAEVAEQKIKKSGDEISIK
CCCCCCCEEEEECHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEE
LIKNPDIISDVGHLKTHRPFTVGFAAETQNIDDYAKDKLERKNLDMICANDVSGGQVFNA
EECCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEECC
DENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
CCHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLNGKHIVVGITGGIAAYKTIELIRLLRKAEAEVRVVLTPAAAEFVTPLTLQAISGNAV
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEECCCHHH
AQSLLDPQAELAMGHIELAKWADAIIIAPASADFIARLTIGMANDLLSTICLATDAPIFL
HHHHHCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEE
APAMNQQMYHQSITQQNLTTLQTRGIELIGPNSGFQACGDMGKGRMSEPEEIFTALSDFL
ECCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
SQKQDLQGLNVSITAGPTREAIDPVRYISNHSSGKMGFAIAEAFAKRGANVTLISGPVNL
HHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCEEE
TTPKNVNRINVISAQEMWQASLESAVKNQIFIGCAAVADYRVAEVAEQKIKKSGDEISIK
CCCCCCCEEEEECHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEE
LIKNPDIISDVGHLKTHRPFTVGFAAETQNIDDYAKDKLERKNLDMICANDVSGGQVFNA
EECCCCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEECC
DENALQLFWKNGHKKLSLKSKVELAADLVNEIIERYQKTL
CCHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]