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The map label for this gene is kefBC [H]

Identifier: 148828089

GI number: 148828089

Start: 1496197

End: 1498053

Strand: Direct

Name: kefBC [H]

Synonym: CGSHiGG_08115

Alternate gene names: 148828089

Gene position: 1496197-1498053 (Clockwise)

Preceding gene: 148828088

Following gene: 148828090

Centisome position: 79.28

GC content: 37.86

Gene sequence:

>1857_bases
ATGTCTCAACTTGCCAATCCAGAACTGATGAAAGTCGTTATTTTACTCGCATCTAGCGTAACAATTGTGCCGTTATTTAA
AAGACTCGGGTTGGGTAGCGTGCTAGGTTATTTAGTGGCAGGTTGTTTGATTGGCCCATCTGTCTTTGGCATAGTGCAAG
ATCCAACAGCTGTGGTACATTTAGCGGAATTAGGTGTGGTAATGTTTCTTTTTATTATCGGGCTTGAAATGTATCCAGAA
CGCCTTTGGGCAATGCGTAAAGCTATTTTTGGCAGAGGTTTGTTACAAGTTGGATTATGTGGTTGCTTACTCACTTTTTC
GGGTATTTATTTATTAGGATTAACAAAAGAAGTATCATTTATCGCTGGTATGGGTTTCACGCTTTCCTCTACTGCTATTG
TAATGCAATCACTAGAAGAAAGGGGGCTTACTTCTACGTCAAAAGGACAACGCGTAATTTCGACGTTAATTTTTGAAGAT
ATTGCTATTGTACCACTTTTGGCTTCTGTCGCTTTTCTTGCTCCCCATTCGAAAGAAGCGACACCACATACTGATTGGGT
ATCAATTGGTATAGCATTAAGTGCTGTTGTGGGGTTAATTGTGACTGGAAAATGGTTAATGAACCCACTATTTCGTTTAA
TTTCTAAAGCACGTATTCGTGAAATGATGACAGCGGGCGCATTATTGGTCGTTTTAGGTGCTGCATTAGCAATGGAAATT
GGCGGACTTTCAATGGCAATGGGCGCGTTTGTTGCTGGTGTGATGATGTCTGAATCAGCGTTTCGCCATCAGCTTGAAGC
GGATATAGAACCATTTCGCGGCTTATTACTCGGATTATTTTTTATGGGCGTAGGAATGTCCTTAGATTTGCATTTAGTGT
TTAATCATTGGATCTTGCTACTTGGAATTGTTTTTCTTTATATACTTGGAAAAGCCAGTGCTGTTTATATTATTGCCCGA
ATTACCCGTCTTGATCATCGAGAAGCCATAGGACGAATGTCTTTGATGGCACACGGTGGCGAATTTGCTTTCGTTCTTTT
TTCAGCCGCAGCAACTGCGGAAGTAATCAGTAATGAAGAACAAGCGACATTCACTGCTGCAGTGATTATTTCGATGCTTT
TTTCGCCTATTATTGCTCAAATTGCTCGCAAACTTATACAGCGTACAGAGCCTAAACATCTTGATCAGCTTGATGAAAAT
GATCTAGACAGCATCGTGGATTTGGAAGATAACGTTTTAGTTATTGGTTTTGGACGTTTTAGTCAAATTGTCTGCCAAAC
ATTATTGATTCGTGGAATTAGCGTTTCAGTGATTGATCGCAATATCGAAAATATCCGTGCTGCCGCAAAGTTTGGTTTTA
AAGTTTATTATGGCGATGGCATTCGATTAGATGTTTTACGAGCCGCAGGAATTGAAAAGGCGAAATGTGTCGTATTAGGT
ATTAACGATACACAAAGAATTGAACATATTGTCAGTCAAATGAAAGAGGCTTATCCAAATTTACCGATTTTAACCCGAAC
TTATGACAGAAAAACAACAGTTAGTTTGATTAAGCAGGATGTAGATTTTATTGTGCGTGAAACTTTTGAATCAGCAATTA
CACTTAGTCGAGCAACATTGATGAAATTAGGTATTGATAAAATTGAAGCGGAAGAAATTATTAAGGAAGTACGAACATTG
GATCAAGAACGGTTAAATGAAGAAGTTTTACACGGTTTTTCGAATGAAATAGTAAAAAAATATTGGACACCAAGACCATT
TATTAAACCGCATCTTGATACAAAAGCATTAAATAAAGAAACAGAAGAAATTCTAAGTGAGAAAATTGAAGAAGAAATAT
CAAATGATCATTCATAA

Upstream 100 bases:

>100_bases
TGGTTTAAAGTTATATTAAAAGATTTAGTATGATTTATCACATATAACTTTTTAATATACTCGCCAAAATATTTGTATTT
TTTGCATTATTGGAGTCATT

Downstream 100 bases:

>100_bases
AATTATTTTTTATCTTTAGTGATATTTTTTATCTATAAAAATATTAAATTTTAACTTCTCGTTTAAGTATTTACTTTTGA
GTGATTTAAATCACGTAAAT

Product: glutathione-regulated potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQDPTAVVHLAELGVVMFLFIIGLEMYPE
RLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFED
IAIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEI
GGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIAR
ITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDEN
DLDSIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLG
INDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTL
DQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS

Sequences:

>Translated_618_residues
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQDPTAVVHLAELGVVMFLFIIGLEMYPE
RLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFED
IAIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEI
GGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIAR
ITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDEN
DLDSIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLG
INDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTL
DQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS
>Mature_617_residues
SQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQDPTAVVHLAELGVVMFLFIIGLEMYPER
LWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSFIAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFEDI
AIVPLLASVAFLAPHSKEATPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEIG
GLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILLLGIVFLYILGKASAVYIIARI
TRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEEQATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDEND
LDSIVDLEDNVLVIGFGRFSQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLGI
NDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATLMKLGIDKIEAEEIIKEVRTLD
QERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKETEEILSEKIEEEISNDHS

Specific function: Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=400, Percent_Identity=26.5, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786232, Length=611, Percent_Identity=38.7888707037643, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI1789749, Length=607, Percent_Identity=36.4085667215816, Blast_Score=394, Evalue=1e-110,
Organism=Escherichia coli, GI1786685, Length=521, Percent_Identity=25.9117082533589, Blast_Score=159, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 68050; Mature: 67919

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQDPTAVVH
CCCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHEEECCCHHHHH
LAELGVVMFLFIIGLEMYPERLWAMRKAIFGRGLLQVGLCGCLLTFSGIYLLGLTKEVSF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGMGFTLSSTAIVMQSLEERGLTSTSKGQRVISTLIFEDIAIVPLLASVAFLAPHSKEA
HHCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPHTDWVSIGIALSAVVGLIVTGKWLMNPLFRLISKARIREMMTAGALLVVLGAALAMEI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGLSMAMGAFVAGVMMSESAFRHQLEADIEPFRGLLLGLFFMGVGMSLDLHLVFNHWILL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
LGIVFLYILGKASAVYIIARITRLDHREAIGRMSLMAHGGEFAFVLFSAAATAEVISNEE
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCH
QATFTAAVIISMLFSPIIAQIARKLIQRTEPKHLDQLDENDLDSIVDLEDNVLVIGFGRF
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHCCCCCEEEEECCHH
SQIVCQTLLIRGISVSVIDRNIENIRAAAKFGFKVYYGDGIRLDVLRAAGIEKAKCVVLG
HHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHCEEEEECCCCEEEHHHHCCCCCCCEEEEE
INDTQRIEHIVSQMKEAYPNLPILTRTYDRKTTVSLIKQDVDFIVRETFESAITLSRATL
CCCHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKLGIDKIEAEEIIKEVRTLDQERLNEEVLHGFSNEIVKKYWTPRPFIKPHLDTKALNKE
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
TEEILSEKIEEEISNDHS
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQLANPELMKVVILLASSVTIVPLFKRLGLGSVLGYLVAGCLIGPSVFGIVQDPTAVVH
CCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHEEECCCHHHHH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HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]