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The map label for this gene is fkpA [C]

Identifier: 148827766

GI number: 148827766

Start: 1119329

End: 1120054

Strand: Direct

Name: fkpA [C]

Synonym: CGSHiGG_06145

Alternate gene names: 148827766

Gene position: 1119329-1120054 (Clockwise)

Preceding gene: 148827764

Following gene: 148827767

Centisome position: 59.31

GC content: 35.81

Gene sequence:

>726_bases
ATGTTAAAAATTCAAAAATTATCTATCGCAGCATTAATGGTAAGTGCGGTAATTTCTGGTCAAGTTTTTGCAGAAGATAA
CACATTCGATGAAAAAGCGGCATCTTATGCAGTAGGTGCGTTAATGGGCAGTCAAATGAAAGATCTTGTTGATTCCCACA
AAGAAGTCATTAAATATGATAATGCACGTATTTTAGATGGCTTAAAAGATGCTTTAGAAGGCAAAGTGGATGTTCGTAAA
GATGAAAAAATCCAAAAAACCTTAGAATCTATTGAAGCAAAATTAGTGGCTGCATCAAAAGCAAAAGCAGAAGCGATTGC
TAAACAAGCAAAAGAAGAAGGCGATAAATTCCGTGCTGAATTTGCTAAAGGGAAAGATGTAAAAACGACGCAATCTGGTT
TAATGTATAAAATTGAAAGTGCAGGTAAAGGCGATACAATCAAATCAACGGATACCGTTAAAGTACATTACACGGGTAAA
TTACCAAATGGAAAAGTATTTGATAGCTCTGTCGAGCGCGGACAACCTGTAGAATTCCAACTTGATCAAGTAATTAAAGG
CTGGACTGAAGGTCTTCAATTAGTGAAAAAAGGCGGAAAAATTCAATTAGTTATTGCACCTGAATTAGGCTATGGCGAAC
AAGGTGCTGGCGCATCTATTCCACCAAATTCAACATTAATTTTTGATGTGGAAGTATTAGACGTCAATCCGAAATCTGAA
AAATAA

Upstream 100 bases:

>100_bases
CATAAATTTTCTCTAAATTCTAAAAAAAAGTTGAGAATAGATAGAAAGCCATTTAATCTATTCCTCGTATTATTCCATTC
ATTATAAAGGATTAACTTAT

Downstream 100 bases:

>100_bases
CGGATAAGTTTAATAGCGCGCGTTCTTTAACGCGTGCTTTTTATTATAAAAAACGAGCGGAATTTTTACCGCACTTTTAA
CCTAACGCTATGACATTAAA

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGALMGSQMKDLVDSHKEVIKYDNARILDGLKDALEGKVDVRK
DEKIQKTLESIEAKLVAASKAKAEAIAKQAKEEGDKFRAEFAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGK
LPNGKVFDSSVERGQPVEFQLDQVIKGWTEGLQLVKKGGKIQLVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
K

Sequences:

>Translated_241_residues
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGALMGSQMKDLVDSHKEVIKYDNARILDGLKDALEGKVDVRK
DEKIQKTLESIEAKLVAASKAKAEAIAKQAKEEGDKFRAEFAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGK
LPNGKVFDSSVERGQPVEFQLDQVIKGWTEGLQLVKKGGKIQLVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
K
>Mature_241_residues
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGALMGSQMKDLVDSHKEVIKYDNARILDGLKDALEGKVDVRK
DEKIQKTLESIEAKLVAASKAKAEAIAKQAKEEGDKFRAEFAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGK
LPNGKVFDSSVERGQPVEFQLDQVIKGWTEGLQLVKKGGKIQLVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
K

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=92, Percent_Identity=50, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI17149844, Length=92, Percent_Identity=50, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI17149842, Length=92, Percent_Identity=50, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI224809329, Length=117, Percent_Identity=41.8803418803419, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI224809327, Length=117, Percent_Identity=41.8803418803419, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4758384, Length=117, Percent_Identity=41.8803418803419, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4758380, Length=99, Percent_Identity=46.4646464646465, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI224809331, Length=117, Percent_Identity=41.8803418803419, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI17149836, Length=97, Percent_Identity=46.3917525773196, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4503725, Length=97, Percent_Identity=46.3917525773196, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4503729, Length=117, Percent_Identity=36.7521367521368, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI4503727, Length=107, Percent_Identity=39.2523364485981, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI8923659, Length=101, Percent_Identity=41.5841584158416, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI33469985, Length=95, Percent_Identity=41.0526315789474, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI192448443, Length=103, Percent_Identity=37.8640776699029, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1789745, Length=209, Percent_Identity=47.3684210526316, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI87082390, Length=210, Percent_Identity=42.8571428571429, Blast_Score=155, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71993519, Length=99, Percent_Identity=44.4444444444444, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17540882, Length=93, Percent_Identity=46.2365591397849, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17561782, Length=114, Percent_Identity=41.2280701754386, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324194, Length=100, Percent_Identity=50, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=51.1363636363636, Blast_Score=85, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323482, Length=111, Percent_Identity=39.6396396396396, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323566, Length=129, Percent_Identity=34.8837209302326, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281363946, Length=91, Percent_Identity=53.8461538461538, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17352457, Length=91, Percent_Identity=53.8461538461538, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24655568, Length=99, Percent_Identity=44.4444444444444, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=42.3076923076923, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647110, Length=115, Percent_Identity=40.8695652173913, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356629, Length=95, Percent_Identity=49.4736842105263, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26045; Mature: 26045

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGALMGSQMKDLVDSHKEVIKYD
CCEEHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NARILDGLKDALEGKVDVRKDEKIQKTLESIEAKLVAASKAKAEAIAKQAKEEGDKFRAE
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGKLPNGKVFDSSVERGQPVEFQ
HHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEECCHHCCCCCCCCH
LDQVIKGWTEGLQLVKKGGKIQLVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCC
K
C
>Mature Secondary Structure
MLKIQKLSIAALMVSAVISGQVFAEDNTFDEKAASYAVGALMGSQMKDLVDSHKEVIKYD
CCEEHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NARILDGLKDALEGKVDVRKDEKIQKTLESIEAKLVAASKAKAEAIAKQAKEEGDKFRAE
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAKGKDVKTTQSGLMYKIESAGKGDTIKSTDTVKVHYTGKLPNGKVFDSSVERGQPVEFQ
HHCCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCCCEECCHHCCCCCCCCH
LDQVIKGWTEGLQLVKKGGKIQLVIAPELGYGEQGAGASIPPNSTLIFDVEVLDVNPKSE
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]