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The map label for this gene is hisA

Identifier: 148827671

GI number: 148827671

Start: 1022242

End: 1022991

Strand: Direct

Name: hisA

Synonym: CGSHiGG_05610

Alternate gene names: 148827671

Gene position: 1022242-1022991 (Clockwise)

Preceding gene: 148827670

Following gene: 148827672

Centisome position: 54.17

GC content: 40.53

Gene sequence:

>750_bases
ATGAAACAATCTATTATTATCCCTGCTCTTGATCTTATCAATGGTCAAGTTGTGCGGTTACACCAAGGCGATTATGCCAA
GCAAACTACCTATTCTGACAATCCAATTAAGCAATTTGATAATTATGTACGTCAAGGAGCAAAACAACTACATCTAGTCG
ATTTAACGGGAGCGAAAAATCCCCAGTCAAGACAAACCGCACTTATTGGAAAAATCGTTGAAGCAACACAATGTAAAGTA
CAAGTAGGAGGAGGCATTCGTACAGAGCAAGATGTGGCAGATTTATTGGCTGTGGGTGCGAATCGCGTGGTGATTGGTTC
AACCGCCGTAACTCATCGTTCAATGGTGAAAAACTGGTTCATCAAATATGGTGCGGAAAAATTTGTTCTAGCATTAGACG
TGAATATTAATGCAAGCGGTCAGAAAATCGTTGCGATTAGCGGTTGGCAGGAAGAAAGTGGTGTACTATTAGAAACGTTG
ATCGAAGATTTCCAAACCGTTGGCTTACAACAAGTTTTATGTACCGATATTTCACGCGATGGCACCTTGACAGGTTCAAA
TATTGGACTTTATCAAGAAATTTGTGAGAAATATCCACCTATTCAGTTTCAATCTTCTGGAGGGATTGGTTCACTGGCTG
ATATTGAGGCTCTAAAAGGCACAGGTGTGTCAGGTGTAATTGTAGGTCGCGCTTTATTAGAAGGAAAATTTACGCTTTCG
GAGGCAATCAAATGTTGGCAAAACGGATAA

Upstream 100 bases:

>100_bases
CCGAACGTTCGGGTAAAAATGGTGCGTTGTTGCTAAAAAATTTTGTGGAAAAAGTACCGTTTTAATCACTAGATCATATA
GTCATACAGGATCAAACACA

Downstream 100 bases:

>100_bases
TTCCTTGTTTGGATGTACGTGATGGACAGGTAGTAAAAGGGGTACAATTCCGTAACCACGAAATTATTGGCGATATTGTG
CCACTTGCTCAACGCTATGC

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MKQSIIIPALDLINGQVVRLHQGDYAKQTTYSDNPIKQFDNYVRQGAKQLHLVDLTGAKNPQSRQTALIGKIVEATQCKV
QVGGGIRTEQDVADLLAVGANRVVIGSTAVTHRSMVKNWFIKYGAEKFVLALDVNINASGQKIVAISGWQEESGVLLETL
IEDFQTVGLQQVLCTDISRDGTLTGSNIGLYQEICEKYPPIQFQSSGGIGSLADIEALKGTGVSGVIVGRALLEGKFTLS
EAIKCWQNG

Sequences:

>Translated_249_residues
MKQSIIIPALDLINGQVVRLHQGDYAKQTTYSDNPIKQFDNYVRQGAKQLHLVDLTGAKNPQSRQTALIGKIVEATQCKV
QVGGGIRTEQDVADLLAVGANRVVIGSTAVTHRSMVKNWFIKYGAEKFVLALDVNINASGQKIVAISGWQEESGVLLETL
IEDFQTVGLQQVLCTDISRDGTLTGSNIGLYQEICEKYPPIQFQSSGGIGSLADIEALKGTGVSGVIVGRALLEGKFTLS
EAIKCWQNG
>Mature_249_residues
MKQSIIIPALDLINGQVVRLHQGDYAKQTTYSDNPIKQFDNYVRQGAKQLHLVDLTGAKNPQSRQTALIGKIVEATQCKV
QVGGGIRTEQDVADLLAVGANRVVIGSTAVTHRSMVKNWFIKYGAEKFVLALDVNINASGQKIVAISGWQEESGVLLETL
IEDFQTVGLQQVLCTDISRDGTLTGSNIGLYQEICEKYPPIQFQSSGGIGSLADIEALKGTGVSGVIVGRALLEGKFTLS
EAIKCWQNG

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=63.1147540983607, Blast_Score=324, Evalue=3e-90,
Organism=Escherichia coli, GI1788336, Length=231, Percent_Identity=23.3766233766234, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_HAEI8 (Q4QN70)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248187.1
- ProteinModelPortal:   Q4QN70
- STRING:   Q4QN70
- GeneID:   3429914
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0604
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   Q4QN70
- ProtClustDB:   PRK00748
- BioCyc:   HINF281310:NTHI0604-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26861; Mature: 26861

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: ACT_SITE 11-11 ACT_SITE 133-133

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSIIIPALDLINGQVVRLHQGDYAKQTTYSDNPIKQFDNYVRQGAKQLHLVDLTGAKN
CCCCEEECHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCHHEEEEEEECCCCC
PQSRQTALIGKIVEATQCKVQVGGGIRTEQDVADLLAVGANRVVIGSTAVTHRSMVKNWF
CCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
IKYGAEKFVLALDVNINASGQKIVAISGWQEESGVLLETLIEDFQTVGLQQVLCTDISRD
HHCCCCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GTLTGSNIGLYQEICEKYPPIQFQSSGGIGSLADIEALKGTGVSGVIVGRALLEGKFTLS
CCCCCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHH
EAIKCWQNG
HHHHHHCCC
>Mature Secondary Structure
MKQSIIIPALDLINGQVVRLHQGDYAKQTTYSDNPIKQFDNYVRQGAKQLHLVDLTGAKN
CCCCEEECHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCHHEEEEEEECCCCC
PQSRQTALIGKIVEATQCKVQVGGGIRTEQDVADLLAVGANRVVIGSTAVTHRSMVKNWF
CCHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHH
IKYGAEKFVLALDVNINASGQKIVAISGWQEESGVLLETLIEDFQTVGLQQVLCTDISRD
HHCCCCEEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
GTLTGSNIGLYQEICEKYPPIQFQSSGGIGSLADIEALKGTGVSGVIVGRALLEGKFTLS
CCCCCCCCCHHHHHHHHCCCCEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCHH
EAIKCWQNG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA