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The map label for this gene is proC [H]

Identifier: 148827461

GI number: 148827461

Start: 819424

End: 820239

Strand: Direct

Name: proC [H]

Synonym: CGSHiGG_04350

Alternate gene names: 148827461

Gene position: 819424-820239 (Clockwise)

Preceding gene: 148827459

Following gene: 148827462

Centisome position: 43.42

GC content: 41.67

Gene sequence:

>816_bases
ATGCAACACAAATTGATTGCCTTTATTGGTGGCGGCAATATGGCACAAGCTATTATTCTTGGATTATTGAAACAAGGTTA
TCCTGCCGAGCAAATTATTGTGAATGATCCAAATGAAGAAAAAAGAGCATTTTTTGCTAATCTTGGCGTGGCAACTTCAG
AAAATAATGTGGGAAGTGCAATCAAAGCTGAGGTTGTGTTGCTTGCGGTAAAACCTCAAATGATGGCTGAAGTTTGTTCG
CCACTAAGTGCGGTGGATTTTTCCGATAAATTGTTAATTTCCATTGCTGCTGGTATTTCTACTGAACGCTTGAACGCATT
AATTCCAAGTATGAAATCGATAGTGCGCGTCATGCCAAATACGCCAGCATTAGTGGGCGAAGGCATGGCGGGGTTATTTG
CACCGAAAAATACGAGTGAAAATTACCGCACTTTTGCACAAGATTTATTGGGAGCAGTGGGAAGAACGGTTTGGGTGGAT
GATGAAACTCAAATGCACGCAGTCACTGCCGCGTCAGGAAGTAGTCCAGCCTATTTCTTTTTAATGCTGGAAGCGATGCA
GCAAGCCTTAATCAAAATGAATATAGATGAAAAAACTGCGCGTGAATTAGTGCAGCAATCTATGCTTGGTGCAGCCAAAA
TGGTGATAGAAAATCCGCAAATTGCACTTTCAACTTTGCGTGAAAATGTTACCTCGAAAGGTGGCACCACTGCGGCAGCG
TTAGCAGTATTTGACGCACAACATTTGAATCAAACAATAGAACAAGCTATGCAGGCTTGTTTGTCTCGTTCACAAGAAAT
GGAAACTTTATTCTGA

Upstream 100 bases:

>100_bases
GTCAGTCTATAAGTCATTAAATTTTTGAACCACATCGTAACACTTCCTTCAATATAGGGTAGAATGTGCGGTATTATAGC
CCATAAAAGTAGGAAAAACG

Downstream 100 bases:

>100_bases
TGCAAGTTCGTCCTTTTTTATTGGCTCGCACTGAGCTTTCTGGGTTACTACTGCGCTTATGGCGTGTTTTTGCCGTTCTT
CCCCGCATGGTTGAAATCGC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLGVATSENNVGSAIKAEVVLLAVKPQMMAEVCS
PLSAVDFSDKLLISIAAGISTERLNALIPSMKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVD
DETQMHAVTAASGSSPAYFFLMLEAMQQALIKMNIDEKTARELVQQSMLGAAKMVIENPQIALSTLRENVTSKGGTTAAA
LAVFDAQHLNQTIEQAMQACLSRSQEMETLF

Sequences:

>Translated_271_residues
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLGVATSENNVGSAIKAEVVLLAVKPQMMAEVCS
PLSAVDFSDKLLISIAAGISTERLNALIPSMKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVD
DETQMHAVTAASGSSPAYFFLMLEAMQQALIKMNIDEKTARELVQQSMLGAAKMVIENPQIALSTLRENVTSKGGTTAAA
LAVFDAQHLNQTIEQAMQACLSRSQEMETLF
>Mature_271_residues
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLGVATSENNVGSAIKAEVVLLAVKPQMMAEVCS
PLSAVDFSDKLLISIAAGISTERLNALIPSMKSIVRVMPNTPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVD
DETQMHAVTAASGSSPAYFFLMLEAMQQALIKMNIDEKTARELVQQSMLGAAKMVIENPQIALSTLRENVTSKGGTTAAA
LAVFDAQHLNQTIEQAMQACLSRSQEMETLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=29.6992481203008, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI24797097, Length=275, Percent_Identity=32, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI24797095, Length=275, Percent_Identity=31.6363636363636, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI21361454, Length=274, Percent_Identity=30.6569343065693, Blast_Score=111, Evalue=6e-25,
Organism=Escherichia coli, GI1786585, Length=276, Percent_Identity=33.695652173913, Blast_Score=138, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17569021, Length=264, Percent_Identity=32.5757575757576, Blast_Score=131, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=29.2418772563177, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320861, Length=203, Percent_Identity=33.9901477832512, Blast_Score=99, Evalue=7e-22,
Organism=Drosophila melanogaster, GI21358587, Length=269, Percent_Identity=33.0855018587361, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24648116, Length=276, Percent_Identity=32.2463768115942, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=31.7647058823529, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29077; Mature: 29077

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLGVATSENNVGSA
CCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCEECCCCCCCH
IKAEVVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPSMKSIVRVMPN
HEEEEEEEEECHHHHHHHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
TPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVDDETQMHAVTAASGSSPAYFF
CCCHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCHHHH
LMLEAMQQALIKMNIDEKTARELVQQSMLGAAKMVIENPQIALSTLRENVTSKGGTTAAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
LAVFDAQHLNQTIEQAMQACLSRSQEMETLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQHKLIAFIGGGNMAQAIILGLLKQGYPAEQIIVNDPNEEKRAFFANLGVATSENNVGSA
CCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHCCCEECCCCCCCH
IKAEVVLLAVKPQMMAEVCSPLSAVDFSDKLLISIAAGISTERLNALIPSMKSIVRVMPN
HEEEEEEEEECHHHHHHHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
TPALVGEGMAGLFAPKNTSENYRTFAQDLLGAVGRTVWVDDETQMHAVTAASGSSPAYFF
CCCHHCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCCCCHHHH
LMLEAMQQALIKMNIDEKTARELVQQSMLGAAKMVIENPQIALSTLRENVTSKGGTTAAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHH
LAVFDAQHLNQTIEQAMQACLSRSQEMETLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]