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The map label for this gene is mtr [H]

Identifier: 148827440

GI number: 148827440

Start: 799378

End: 800595

Strand: Direct

Name: mtr [H]

Synonym: CGSHiGG_04230

Alternate gene names: 148827440

Gene position: 799378-800595 (Clockwise)

Preceding gene: 148827439

Following gene: 148827447

Centisome position: 42.36

GC content: 39.08

Gene sequence:

>1218_bases
ATGATCATTGCAGGTACAGCGATTGGTGCAGGCATGCTGGCTAACCCAACTTCAACAGCAGGTGTATGGTTTATTGGTTC
AATTCTTGCTTTAATTTATACTTGGTTTTGTATGACGACCTCAGGATTAATGATCCTAGAAGCTAATCTACATTATCCAA
CAGGTTCAAGTTTTGACACTATCGTTAAAGATTTATTAGGAAAAAGTTGGAATACTATCAATGGTCTTTCTGTTGCTTTC
GTCTTGTATATTTTGACTTATGCCTACATAACCTCAGGCGGAGGCATTACACAGAATCTGCTCAACCAAGCATTCAGTTC
TGCTGAAAGTGCGGTAGATATTGGGCGAACTTCAGGATCTTTAATTTTCTGCCTTATTCTTGCAGCCTTTGTATGGCTTT
CAACCAAAGCAGTGGATCGTTTCACAACCGTGTTAATTGTCGGGATGGTGGTTGCTTTTTTCCTTTCTACTACTGGTTTA
TTAAGCTCTGTAAAAACAGCAGTTTTATTCAATACCGTTGCTGAAAGTGAGCAAACATATTTACCTTATTTATTGACCGC
ACTTCCAGTTTGTCTCGTGTCGTTTGGTTTCCACGGAAATGTCCCGAGTCTCGTCAAATATTACGATCGTGATGGTCGTC
GCGTGATGAAATCGATCTTTATTGGTACGGGCTTAGCATTAGTGATTTACATCTTATGGCAGCTCGCTGTACAAGGTAAT
TTACCACGCACTGAATTTGCGCCAGTCATTGAAAAAGGCGGCGATGTTTCTGCATTATTAGAGGCTTTACATAAATATAT
TGAAGTGGAATACCTTTCCGTCGCATTAAATTTCTTTGCTTATATGGCAATTTCTACTTCATTCTTAGGCGTCACTTTAG
GGTTATTTGACTATATTGCGGATCTATTTAAATTTGACGATAGCTTATTAGGCAGAACAAAAACAACACTTGTTACTTTT
TTACCGCCATTATTGCTAAGCCTGCAATTTCCTTATGGATTTGTGATTGCCATTGGTTACGCTGGATTGGCGGCAACAAT
TTGGGCTGCAATTGTCCCCGCACTTCTTGCCAAAGCAAGCCGTCAAAAATTCCCACAAGCAAGTTATAAAGTATACGGCG
GAAATTTTATGATTGGTTTTGTAATGTTATTTGGCATATTAAATATTGTGGCGCAAATTGGGGTAAACTTAGGTTGGTTT
GCAAGTTTTACTGGGTAA

Upstream 100 bases:

>100_bases
ATATATTGCACTTTCCTTGCGTACTATTATAATAGTGCAAATTTATTTTAGAGGCATTTTATGATACAACAAAAAATCTC
CTTCTCTCTTAGGCGGTGCA

Downstream 100 bases:

>100_bases
GTTTTAAAAAATAAATTTAAATTATTAAATAGCGATCTGCACTTTAACAGGTGGGTTATGTAGTCCAACTGATTCGTGCA
GAGCAGCCCTTAATTATTTT

Product: tryptophan-specific transport protein

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLGKSWNTINGLSVAF
VLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGL
LSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLALVIYILWQLAVQGN
LPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDDSLLGRTKTTLVTF
LPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVMLFGILNIVAQIGVNLGWF
ASFTG

Sequences:

>Translated_405_residues
MIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLGKSWNTINGLSVAF
VLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGL
LSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLALVIYILWQLAVQGN
LPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDDSLLGRTKTTLVTF
LPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVMLFGILNIVAQIGVNLGWF
ASFTG
>Mature_405_residues
MIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDTIVKDLLGKSWNTINGLSVAF
VLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGSLIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGL
LSSVKTAVLFNTVAESEQTYLPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLALVIYILWQLAVQGN
LPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIADLFKFDDSLLGRTKTTLVTF
LPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKASRQKFPQASYKVYGGNFMIGFVMLFGILNIVAQIGVNLGWF
ASFTG

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=382, Percent_Identity=53.9267015706806, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1790145, Length=395, Percent_Identity=45.3164556962025, Blast_Score=341, Evalue=4e-95,
Organism=Escherichia coli, GI1788218, Length=391, Percent_Identity=37.8516624040921, Blast_Score=243, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 43753; Mature: 43753

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDT
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHH
IVKDLLGKSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
LIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGLLSSVKTAVLFNTVAESEQTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLALVIYILWQLAVQGN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLFKFDDSLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQKFPQASYKVYGGNFMIGFVMLFGILNIVAQIGVNLGWFASFTG
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCC
>Mature Secondary Structure
MIIAGTAIGAGMLANPTSTAGVWFIGSILALIYTWFCMTTSGLMILEANLHYPTGSSFDT
CEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHH
IVKDLLGKSWNTINGLSVAFVLYILTYAYITSGGGITQNLLNQAFSSAESAVDIGRTSGS
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
LIFCLILAAFVWLSTKAVDRFTTVLIVGMVVAFFLSTTGLLSSVKTAVLFNTVAESEQTY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LPYLLTALPVCLVSFGFHGNVPSLVKYYDRDGRRVMKSIFIGTGLALVIYILWQLAVQGN
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LPRTEFAPVIEKGGDVSALLEALHKYIEVEYLSVALNFFAYMAISTSFLGVTLGLFDYIA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLFKFDDSLLGRTKTTLVTFLPPLLLSLQFPYGFVIAIGYAGLAATIWAAIVPALLAKAS
HHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQKFPQASYKVYGGNFMIGFVMLFGILNIVAQIGVNLGWFASFTG
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]