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The map label for this gene is prlC [H]

Identifier: 148827353

GI number: 148827353

Start: 686436

End: 688475

Strand: Direct

Name: prlC [H]

Synonym: CGSHiGG_03690

Alternate gene names: 148827353

Gene position: 686436-688475 (Clockwise)

Preceding gene: 148827350

Following gene: 148827354

Centisome position: 36.37

GC content: 40.54

Gene sequence:

>2040_bases
ATGTCAAATCCATTACTTAACATTCAAGGCCTACCGCCATTTTCACAAATCAAGCCAGAACACATTCGACCAGCTGTTGA
AAAATTAATTCAAGATTGTCGCAATACGATAGAACAAGTGTTAAAACAACCGCACTTTACTTGGGAAAATTTCATTTTGC
CTTTAACGGAAACTAATGATCGCTTAAATCGTGCTTGGTCACCCGTTTCTCATCTCAATTCAGTAAAAAATAGCACTGAA
TTACGTGAAGCCTATCAAACGTGCTTGCCGTTACTTTCTGAATACAGCACTTGGATTGGTCAGCATAAAGGGCTTTATAA
TGCCTATTTAGCGTTAAAAAATAGTGCTGAATTTGCCGATTATTCTATTGCACAAAAGAAAGCCATTGAAAATTCACTGC
GTGATTTTGAACTTTCAGGCATTGGGCTTTCCGAAGAGAAACAACAACGTTATGGCGAAATTGTGGCGCGCTTATCGGAA
TTAAATTCACAATTTAGCAATAACGTATTAGATGCCACAATGGGTTGGGAAAAACTCATTGAAAACGAAGCAGAACTTGC
TGGTTTACCTGAATCCGCACTACAAGCTGCACAACAATCTGCCGAAAGTAAAGGATTAAAAGGTTATCGTTTTACGTTAG
AAATCCCAAGTTATTTGCCTGTGATGACTTACTGCGAAAATCGTGCATTGCGTGAAGAAATGTACCGTGCTTATGCAACA
CGCGCCTCAGAACAAGGCCCTAATGCAGGCAAATGGGACAACAGTAAAGTTATGGAAGAAATTCTTACATTACGCGTAGA
ACTGGCGAAATTACTCGGTTTTAATACTTATACCGAACTTTCACTTGCCACAAAAATGGCAGAAAACCCACAACAAGTGC
TTGATTTCTTAGATCATCTTGCCGAACGTGCCAAACCACAAGGCGAAAAAGAACTGCAAGAATTGAAAGATTACTGCGAA
AAAGAATTTGGTGTCACGGAACTTGCACCTTGGGATATTGGTTTTTACAGCGAAAAACAAAAACAACATTTATACGCCAT
TAATGATGAAGAACTTCGCCCATATTTTCCAGAAAATCGCGTGATTTCAGGATTGTTTGAATTAATTAAACGCATTTTCA
ATATTCGTGCAGTGGAACGCAAAGGCGTGGATACTTGGCATAAAGATGTGCGTTTCTTTGATTTAATCGATGAAAATGAT
CAACTCCGTGGCAGTTTCTATCTTGATTTATATGCGCGCGAACATAAACGTGGTGGTGCGTGGATGGACGATTATATTGG
GCGCAAGCGTAAACTGGATGGCAGCATTGAAACGCCTGTGGCTTATTTAACTTGCAACTTCAATGCACCGATAGGGAATA
AACCAGCGTTATTTACTCACAATGAAGTCACCACGCTATTCCACGAATTTGGGCACGGAATCCATCATATGCTCACGCAA
ATTGATGTATCCGATGTGGCGGGTATAAATGGCGTGCCTTGGGATGCTGTGGAATTACCAAGTCAATTTATGGAAAACTG
GTGCTGGGAAGAAGAGGCTTTGGCGTTTATTTCAGGACATTACGAAACAGGCGAGCCTTTGCCAAAAGAAAAACTCACGC
AATTGTTAAAAGCGAAAAATTTCCAAGCTGCGATGTTTATCTTACGTCAGCTTGAATTTGGGATTTTTGATTTCCGCTTG
CATCACACCTTTGATGCCGAAAAAACCAATCAAATTTTGGATACACTTAAATCAGTGAAATCACAAGTTGCCGTCATAAA
AGGCGTAGATTGGGCAAGAGCACCACACAGCTTCAGCCATATTTTTGCAGGGGGCTACGCCGCAGGTTATTACAGCTATT
TATGGGCTGAAGTATTATCGGCTGATGCTTATTCACGCTTTGAAGAAGAAGGTATTTTCAACCCAATCACCGGCAAATCA
TTCTTAGATGAAATTCTCACGCGTGGTGGCTCAGAAGAACCAATGGAACTCTTCAAACGCTTCCGTGGCCGTGAACCGCA
ATTAGATGCGTTGTTAAGACATAAAGGAATTATGAACTAA

Upstream 100 bases:

>100_bases
CAAACTATTATTACTGATTTTTTTAGATTTTTCAACCTTGATATTATAGAATTTGCCGTCACATAAAAAAACAGTTTTCA
AAAAAGGAACATTTATGTCT

Downstream 100 bases:

>100_bases
TACGTCAAACTATAGGGCATGCACAACATGCCCTTTCTCAAATATTTTCCTCGACATAAAAACATAGTAAATTTTAACCG
CACTTTATCTAGACAAAACC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTE
LREAYQTCLPLLSEYSTWIGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSE
LNSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKDYCE
KEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDEND
QLRGSFYLDLYAREHKRGGAWMDDYIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRL
HHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKS
FLDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN

Sequences:

>Translated_679_residues
MSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTE
LREAYQTCLPLLSEYSTWIGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSE
LNSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKDYCE
KEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDEND
QLRGSFYLDLYAREHKRGGAWMDDYIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRL
HHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKS
FLDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN
>Mature_678_residues
SNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETNDRLNRAWSPVSHLNSVKNSTEL
REAYQTCLPLLSEYSTWIGQHKGLYNAYLALKNSAEFADYSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSEL
NSQFSNNVLDATMGWEKLIENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYATR
ASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHLAERAKPQGEKELQELKDYCEK
EFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENRVISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQ
LRGSFYLDLYAREHKRGGAWMDDYIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQI
DVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKNFQAAMFILRQLEFGIFDFRLH
HTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSF
LDEILTRGGSEEPMELFKRFRGREPQLDALLRHKGIMN

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=672, Percent_Identity=30.2083333333333, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI14149738, Length=675, Percent_Identity=30.0740740740741, Blast_Score=288, Evalue=2e-77,
Organism=Homo sapiens, GI156105687, Length=664, Percent_Identity=26.0542168674699, Blast_Score=195, Evalue=1e-49,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=71.6814159292035, Blast_Score=1019, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=670, Percent_Identity=29.2537313432836, Blast_Score=292, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI71999758, Length=567, Percent_Identity=27.1604938271605, Blast_Score=165, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI32565901, Length=582, Percent_Identity=22.5085910652921, Blast_Score=108, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6319793, Length=687, Percent_Identity=30.1310043668122, Blast_Score=314, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6322715, Length=704, Percent_Identity=24.5738636363636, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21356111, Length=701, Percent_Identity=27.6747503566334, Blast_Score=253, Evalue=4e-67,
Organism=Drosophila melanogaster, GI20129717, Length=586, Percent_Identity=26.6211604095563, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77932; Mature: 77801

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETND
CCCCCEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCH
RLNRAWSPVSHLNSVKNSTELREAYQTCLPLLSEYSTWIGQHKGLYNAYLALKNSAEFAD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHH
YSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSELNSQFSNNVLDATMGWEKLI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
CCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHH
AERAKPQGEKELQELKDYCEKEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENR
HHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCHH
VISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQLRGSFYLDLYAREHKRGGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEEEECCCCCCCCEEEEEEEHHHHCCCCC
WMDDYIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
CHHHHCCCHHCCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKN
CCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFILRQLEFGIFDFRLHHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSH
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHH
IFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSFLDEILTRGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FRGREPQLDALLRHKGIMN
HCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLNIQGLPPFSQIKPEHIRPAVEKLIQDCRNTIEQVLKQPHFTWENFILPLTETND
CCCCEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCH
RLNRAWSPVSHLNSVKNSTELREAYQTCLPLLSEYSTWIGQHKGLYNAYLALKNSAEFAD
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHH
YSIAQKKAIENSLRDFELSGIGLSEEKQQRYGEIVARLSELNSQFSNNVLDATMGWEKLI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ENEAELAGLPESALQAAQQSAESKGLKGYRFTLEIPSYLPVMTYCENRALREEMYRAYAT
CCCHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RASEQGPNAGKWDNSKVMEEILTLRVELAKLLGFNTYTELSLATKMAENPQQVLDFLDHL
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHH
AERAKPQGEKELQELKDYCEKEFGVTELAPWDIGFYSEKQKQHLYAINDEELRPYFPENR
HHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCHH
VISGLFELIKRIFNIRAVERKGVDTWHKDVRFFDLIDENDQLRGSFYLDLYAREHKRGGA
HHHHHHHHHHHHHHHHHHHHCCCHHHHHCCHHEEEECCCCCCCCEEEEEEEHHHHCCCCC
WMDDYIGRKRKLDGSIETPVAYLTCNFNAPIGNKPALFTHNEVTTLFHEFGHGIHHMLTQ
CHHHHCCCHHCCCCCCCCCEEEEEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHH
IDVSDVAGINGVPWDAVELPSQFMENWCWEEEALAFISGHYETGEPLPKEKLTQLLKAKN
CCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFILRQLEFGIFDFRLHHTFDAEKTNQILDTLKSVKSQVAVIKGVDWARAPHSFSH
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCHHHH
IFAGGYAAGYYSYLWAEVLSADAYSRFEEEGIFNPITGKSFLDEILTRGGSEEPMELFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FRGREPQLDALLRHKGIMN
HCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]