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The map label for this gene is thrC [H]

Identifier: 148827236

GI number: 148827236

Start: 545011

End: 546288

Strand: Reverse

Name: thrC [H]

Synonym: CGSHiGG_02985

Alternate gene names: 148827236

Gene position: 546288-545011 (Counterclockwise)

Preceding gene: 148827237

Following gene: 148827235

Centisome position: 28.95

GC content: 39.2

Gene sequence:

>1278_bases
ATGAATTTATACAATATCAAACACCCAGAAGAACAAGTCACTTTTTCTGAGGCTGTTCGTCAAGGTCTTGGGCGGGATCA
AGGTCTATTCTTTCCAGAAGTTATTCCTCAACTTAATAACATTAATGAATTACTTGAATTGCCTCTTGTTGAGCGTAGTC
AAAAAATTCTAGGTGCATTAATTGATGGCGAGTTACCACAAGCAACGTTAGATGCAATGGTAAAAAATGCGTTTACTTTC
ACTGCACCGTTAGAAAAAGTGGAAGATAATATTTATGCACTTGAATTATTTCACGGTCCAACGCTAGCATTTAAAGATTT
TGGTGGGCGTTTTATGGCTCAGGCGCTTGCAGCAGTTCGTGGTGATGGCAAAATTACTATTTTAACGGCAACCTCAGGCG
ATACTGGAGCCGCTGTAGCACATGCGTTTTATGGATTAGAAAATATTAATGTAGTTATCCTTTATCCAAAAGGCAAAATC
AGCCCATTGCAAGAAAAGCTGTTCTGTACTTTAGGTGGGAATATTCGTACTGTTGCGATTAACGCTGATTTCGATGCGTG
TCAGGCTTTGGTTAAGCAAGCCTTTGATGATGTTGAATTGCGCCAAGCTATCGGGCTTAACTCTGCAAATTCTATTAATA
TCAGCCGTTTATTAGCTCAAGTTTGTTATTACTTTGAGGCTGTCGCACAATTGCCAAAAGAAAAACGTGATAATGTCGTG
GTTTCTGTGCCAAGTGGTAATTTTGGTAACTTAACGGCGGGATTAATTGCAAAAACCTTAGGATTGCAAATAAAACGCTT
TGTCGCCTCAACAAACGCAAATGATACTGTGCCACGTTATTTGAAATCGGGTAATTGGGATCCTAAAACGACAGTTTCAA
CCCTTTCTAATGCAATGGATGTAAGTCGCCCAAATAATTGGCCGAGAGTGGAGGAATTGTTTAAACGAAATGGTTGGGAT
TTAACTGATTTAGGTTCGGAGATGCTAAGTGATAGCGAAACAGAAGATACCTTAAAAACGATGCAGTCGAAAGGTTATTT
ATGTGAACCTCACGGTGCGATAGCTTACCAAGTGCTGAAAGATCAACTTAAAGCGAGTGAAATAGGAATCTTCCTGTGTA
CGGCACATCCTGCGAAATTTAAAGAATCCGTAGAACGTATTCTTGGTATTCAGCTTCCATTACCTGAAACACTGGATAAA
CATAATCAGCTACCATTGCTTTCAGATGAAATGGATAATGATTTTGCACAACTACGGGCTTACTTATTGAAGTCATAA

Upstream 100 bases:

>100_bases
TGAAGGTTTTGTGCATGTATGTAAAGTTGATAACGAAGGCACAAGAGAAATTAAATAAGTTAATTTAAATAGATGAAATC
AGATTAAAAACGGATTAAAT

Downstream 100 bases:

>100_bases
AGTGCGGTAAATTTTTATTGTGTTTTGGATAGCATCTGATTTTCAGGTGCTATTTTATTTTTAGAAAATAGGGTATAGAG
ATAAAAAATAAGGATATATT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MNLYNIKHPEEQVTFSEAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGALIDGELPQATLDAMVKNAFTF
TAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLQIKRFVASTNANDTVPRYLKSGNWDPKTTVSTLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSEMLSDSETEDTLKTMQSKGYLCEPHGAIAYQVLKDQLKASEIGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS

Sequences:

>Translated_425_residues
MNLYNIKHPEEQVTFSEAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGALIDGELPQATLDAMVKNAFTF
TAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLQIKRFVASTNANDTVPRYLKSGNWDPKTTVSTLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSEMLSDSETEDTLKTMQSKGYLCEPHGAIAYQVLKDQLKASEIGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS
>Mature_425_residues
MNLYNIKHPEEQVTFSEAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGALIDGELPQATLDAMVKNAFTF
TAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVRGDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKI
SPLQEKLFCTLGGNIRTVAINADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
VSVPSGNFGNLTAGLIAKTLGLQIKRFVASTNANDTVPRYLKSGNWDPKTTVSTLSNAMDVSRPNNWPRVEELFKRNGWD
LTDLGSEMLSDSETEDTLKTMQSKGYLCEPHGAIAYQVLKDQLKASEIGIFLCTAHPAKFKESVERILGIQLPLPETLDK
HNQLPLLSDEMDNDFAQLRAYLLKS

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=460, Percent_Identity=30.6521739130435, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI149193323, Length=419, Percent_Identity=30.0715990453461, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=65.6470588235294, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319901, Length=446, Percent_Identity=34.7533632286996, Blast_Score=219, Evalue=7e-58,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 46835; Mature: 46835

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLYNIKHPEEQVTFSEAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHH
IDGELPQATLDAMVKNAFTFTAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVR
HCCCCCHHHHHHHHHHHHEECCCHHHHCCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHC
GDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHEEEEECCCEEEEEE
NADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCEE
VSVPSGNFGNLTAGLIAKTLGLQIKRFVASTNANDTVPRYLKSGNWDPKTTVSTLSNAMD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWDLTDLGSEMLSDSETEDTLKTMQSKGYLCEPHGAIAYQVLK
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCHHHHHHHH
DQLKASEIGIFLCTAHPAKFKESVERILGIQLPLPETLDKHNQLPLLSDEMDNDFAQLRA
HHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
YLLKS
HHHCC
>Mature Secondary Structure
MNLYNIKHPEEQVTFSEAVRQGLGRDQGLFFPEVIPQLNNINELLELPLVERSQKILGAL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHH
IDGELPQATLDAMVKNAFTFTAPLEKVEDNIYALELFHGPTLAFKDFGGRFMAQALAAVR
HCCCCCHHHHHHHHHHHHEECCCHHHHCCCEEEEEEECCCCEEHHHCCHHHHHHHHHHHC
GDGKITILTATSGDTGAAVAHAFYGLENINVVILYPKGKISPLQEKLFCTLGGNIRTVAI
CCCEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHEEEEECCCEEEEEE
NADFDACQALVKQAFDDVELRQAIGLNSANSINISRLLAQVCYYFEAVAQLPKEKRDNVV
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCEE
VSVPSGNFGNLTAGLIAKTLGLQIKRFVASTNANDTVPRYLKSGNWDPKTTVSTLSNAMD
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHH
VSRPNNWPRVEELFKRNGWDLTDLGSEMLSDSETEDTLKTMQSKGYLCEPHGAIAYQVLK
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEECCCCHHHHHHHH
DQLKASEIGIFLCTAHPAKFKESVERILGIQLPLPETLDKHNQLPLLSDEMDNDFAQLRA
HHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHH
YLLKS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]