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The map label for this gene is ppiB [H]

Identifier: 148827230

GI number: 148827230

Start: 539432

End: 539941

Strand: Direct

Name: ppiB [H]

Synonym: CGSHiGG_02935

Alternate gene names: 148827230

Gene position: 539432-539941 (Clockwise)

Preceding gene: 148827228

Following gene: 148827231

Centisome position: 28.58

GC content: 35.88

Gene sequence:

>510_bases
ATGGTTACATTACACACAAATTTTGGCGACATTAAAATTAAATTGGATTTTGATAAAGCTCCAGTTACGGCAGAAAATTT
CTTAAATTACTGCAAAGAAGGTTTTTATAATAACACAATTTTTCATCGTGTTATTGATGGCTTTATGATTCAAGGCGGTG
GTATGGAAAGCGGTATGCGTGAAAAAGCAACTAAAGCACCAATCCAAAATGAAGCGAACAATCGTTTAAGCAACAAACGT
GGAACCATTGCAATGGCTCGCACTTCAGATCCACATTCAGCGACAGCACAATTTTTCATTAACGTGGCAGACAATGATTT
CTTAAATTATCGTTCAAAAGAAATGTTTGGTCGAGAAGTCGTTCAAGAATGGGGCTATGCGGTATTTGGTGAAGTGGTTG
AAGGTATGGATGTTGTTGATAAAATCAAAAAAGTGAAAACAGGCAACAAAGGTTTTCATCAAGATGTTCCAACTGAAGAT
GTAGTGATTACATTGGTTTCAGTAGAATAA

Upstream 100 bases:

>100_bases
TTAAGCTCGTAAAATGAAATAAAAACAAACCGCACTTTTATAGCACTTTTACCTCGATTGTGGAATAATACGACCCTTAA
TTTTTTAGAGGGAAAACAAA

Downstream 100 bases:

>100_bases
TGGTGAATGGCGGATGAATTCCGCCATTTTTTATCGACCTAAAGGAAAATGCTCATGCCTTTCTTCGACACTCACACGCA
TCTTGATTATCTCCAACAAT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKEGFYNNTIFHRVIDGFMIQGGGMESGMREKATKAPIQNEANNRLSNKR
GTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTED
VVITLVSVE

Sequences:

>Translated_169_residues
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKEGFYNNTIFHRVIDGFMIQGGGMESGMREKATKAPIQNEANNRLSNKR
GTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTED
VVITLVSVE
>Mature_169_residues
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKEGFYNNTIFHRVIDGFMIQGGGMESGMREKATKAPIQNEANNRLSNKR
GTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREVVQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTED
VVITLVSVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=168, Percent_Identity=34.5238095238095, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI22547212, Length=170, Percent_Identity=33.5294117647059, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI7657473, Length=170, Percent_Identity=33.5294117647059, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI22547215, Length=170, Percent_Identity=33.5294117647059, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=42.1487603305785, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI24308049, Length=169, Percent_Identity=34.9112426035503, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=31.5151515151515, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI5454154, Length=151, Percent_Identity=32.4503311258278, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310110104, Length=159, Percent_Identity=31.4465408805031, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310129267, Length=159, Percent_Identity=30.188679245283, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI310120620, Length=159, Percent_Identity=30.188679245283, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=168, Percent_Identity=70.8333333333333, Blast_Score=240, Evalue=4e-65,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=56.1728395061728, Blast_Score=183, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71980590, Length=152, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=152, Percent_Identity=36.8421052631579, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=34.1176470588235, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=171, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=150, Percent_Identity=32, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71997782, Length=106, Percent_Identity=35.8490566037736, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=153, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI19922376, Length=167, Percent_Identity=34.1317365269461, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=31.7647058823529, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922912, Length=165, Percent_Identity=34.5454545454545, Blast_Score=76, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24652460, Length=158, Percent_Identity=29.746835443038, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357249, Length=121, Percent_Identity=35.5371900826446, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18992; Mature: 18992

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKEGFYNNTIFHRVIDGFMIQGGGMESGMR
CEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHEEECCCCCCCHH
EKATKAPIQNEANNRLSNKRGTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREV
HHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTEDVVITLVSVE
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVTLHTNFGDIKIKLDFDKAPVTAENFLNYCKEGFYNNTIFHRVIDGFMIQGGGMESGMR
CEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHEEECCCCCCCHH
EKATKAPIQNEANNRLSNKRGTIAMARTSDPHSATAQFFINVADNDFLNYRSKEMFGREV
HHHHHCCCCCCHHHHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
VQEWGYAVFGEVVEGMDVVDKIKKVKTGNKGFHQDVPTEDVVITLVSVE
HHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]