Click here to switch to the map view.

The map label for this gene is lpxK [H]

Identifier: 148827213

GI number: 148827213

Start: 514480

End: 515382

Strand: Reverse

Name: lpxK [H]

Synonym: CGSHiGG_02805

Alternate gene names: 148827213

Gene position: 515382-514480 (Counterclockwise)

Preceding gene: 148827214

Following gene: 148827212

Centisome position: 27.31

GC content: 38.87

Gene sequence:

>903_bases
TTGTTTGGGGATAAAATCTTCTTATCGTGCACCAAAACCAGTGATAATTGTGGGGAATTTGTCTGTGGGTGGAAATGGCA
AAACGCCCGTGGTGGTGTGGCTTGTGGAAGAATTAAAAAACGAGGTTTGCGCGTAGGTGTGATTTCTCGTGGTTACGGCA
GTAAATCTAAAACTTATCCGTTGTTTGTTACTGAAAATACAAATCCAATTGAAGGTGGCGATGAGCCTGTATTGATTGCT
AAACGTACTAATGTTCTTGTCGTGATTTCCCCGAATCGCCAGCAAGCGATTGAATTACTCTTAAGCCAAGCAGAGTGCGA
TATTATTGTTTCTGACGATGGTTTACAGCATTATCAATTACAGCGTGATTTAGAAATTGTCGTAATGGACGCTGAGCGTG
CATTGGGAAATGGTTTTGTATTGCCTGCAGGCCCATTGCGAGAATTACCAAGTCGATTAAAATCCGTAGATTTTGTGATC
ACTAATGGTGGAAAAAATCAGTATTCAGATGCAGTTATGTATCTTGTACCCCATTTCGCGATTAATTTAAAAACCAATGA
AAAACGCCAATTAAAGGAATTTCAATCTGGTGTTGCCATTGCAGGGATTGGCAATCCACAGCGTTTTTTTACTATGTTAG
AAAAGTTAGGGATTCAATTAGAACGAACTCAAGCATTTCAAGATCATCAATATTTTGAAGCCTCTCAATTAGAAAAACTT
TCTGAAAATCAACCGCTCTTTATGACGGAAAAAGATGCCGTAAAATGCCAATCTTTTGCCAAAGATAATTGGTGGTATGT
TCCTGTAGATGCAGAGATTATTGAGGCTGAAAAACAAGGTGAAAATTTACCGCACTTTTGGGACAAAATAGACAAACTTG
TGGCGCAATATAGAAATGGCTGA

Upstream 100 bases:

>100_bases
TTCTATGCCCTTCTGGTATTCCAACTCCAAACTTATTTGGCTCTTATCGCCTTTTTCTTTATTGTTTTTGGTTGATTAGC
CAACTTCGTCGCGCCTTATT

Downstream 100 bases:

>100_bases
AAGGATTAATCTCCAGTTGTTTTGATTGCTTGCCGATAAAGCTGAAATATTAAAGAATAAGGAATAAATTATGTCATTTA
CCGTGATTATCCCTGCTCGT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MFGDKIFLSCTKTSDNCGEFVCGWKWQNARGGVACGRIKKRGLRVGVISRGYGSKSKTYPLFVTENTNPIEGGDEPVLIA
KRTNVLVVISPNRQQAIELLLSQAECDIIVSDDGLQHYQLQRDLEIVVMDAERALGNGFVLPAGPLRELPSRLKSVDFVI
TNGGKNQYSDAVMYLVPHFAINLKTNEKRQLKEFQSGVAIAGIGNPQRFFTMLEKLGIQLERTQAFQDHQYFEASQLEKL
SENQPLFMTEKDAVKCQSFAKDNWWYVPVDAEIIEAEKQGENLPHFWDKIDKLVAQYRNG

Sequences:

>Translated_300_residues
MFGDKIFLSCTKTSDNCGEFVCGWKWQNARGGVACGRIKKRGLRVGVISRGYGSKSKTYPLFVTENTNPIEGGDEPVLIA
KRTNVLVVISPNRQQAIELLLSQAECDIIVSDDGLQHYQLQRDLEIVVMDAERALGNGFVLPAGPLRELPSRLKSVDFVI
TNGGKNQYSDAVMYLVPHFAINLKTNEKRQLKEFQSGVAIAGIGNPQRFFTMLEKLGIQLERTQAFQDHQYFEASQLEKL
SENQPLFMTEKDAVKCQSFAKDNWWYVPVDAEIIEAEKQGENLPHFWDKIDKLVAQYRNG
>Mature_300_residues
MFGDKIFLSCTKTSDNCGEFVCGWKWQNARGGVACGRIKKRGLRVGVISRGYGSKSKTYPLFVTENTNPIEGGDEPVLIA
KRTNVLVVISPNRQQAIELLLSQAECDIIVSDDGLQHYQLQRDLEIVVMDAERALGNGFVLPAGPLRELPSRLKSVDFVI
TNGGKNQYSDAVMYLVPHFAINLKTNEKRQLKEFQSGVAIAGIGNPQRFFTMLEKLGIQLERTQAFQDHQYFEASQLEKL
SENQPLFMTEKDAVKCQSFAKDNWWYVPVDAEIIEAEKQGENLPHFWDKIDKLVAQYRNG

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=239, Percent_Identity=49.7907949790795, Blast_Score=251, Evalue=5e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 33838; Mature: 33838

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGDKIFLSCTKTSDNCGEFVCGWKWQNARGGVACGRIKKRGLRVGVISRGYGSKSKTYP
CCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEHHHHHCCCEEEEEECCCCCCCCEEE
LFVTENTNPIEGGDEPVLIAKRTNVLVVISPNRQQAIELLLSQAECDIIVSDDGLQHYQL
EEEECCCCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCEEEECCCCCCHHHH
QRDLEIVVMDAERALGNGFVLPAGPLRELPSRLKSVDFVITNGGKNQYSDAVMYLVPHFA
CCCEEEEEEECCHHCCCCEEECCCHHHHHHHHHHHEEEEEECCCCCCHHHHHEEEECEEE
INLKTNEKRQLKEFQSGVAIAGIGNPQRFFTMLEKLGIQLERTQAFQDHQYFEASQLEKL
EEECCCCHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCEEEEHHHHHHHHHHCHHHHHHH
SENQPLFMTEKDAVKCQSFAKDNWWYVPVDAEIIEAEKQGENLPHFWDKIDKLVAQYRNG
CCCCCEEEECHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFGDKIFLSCTKTSDNCGEFVCGWKWQNARGGVACGRIKKRGLRVGVISRGYGSKSKTYP
CCCCEEEEEEECCCCCCCCEEEEEEECCCCCCEEEHHHHHCCCEEEEEECCCCCCCCEEE
LFVTENTNPIEGGDEPVLIAKRTNVLVVISPNRQQAIELLLSQAECDIIVSDDGLQHYQL
EEEECCCCCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHHCCCEEEECCCCCCHHHH
QRDLEIVVMDAERALGNGFVLPAGPLRELPSRLKSVDFVITNGGKNQYSDAVMYLVPHFA
CCCEEEEEEECCHHCCCCEEECCCHHHHHHHHHHHEEEEEECCCCCCHHHHHEEEECEEE
INLKTNEKRQLKEFQSGVAIAGIGNPQRFFTMLEKLGIQLERTQAFQDHQYFEASQLEKL
EEECCCCHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCEEEEHHHHHHHHHHCHHHHHHH
SENQPLFMTEKDAVKCQSFAKDNWWYVPVDAEIIEAEKQGENLPHFWDKIDKLVAQYRNG
CCCCCEEEECHHHHHHHHHCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA