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The map label for this gene is moaA [H]

Identifier: 148827100

GI number: 148827100

Start: 373843

End: 374856

Strand: Reverse

Name: moaA [H]

Synonym: CGSHiGG_02115

Alternate gene names: 148827100

Gene position: 374856-373843 (Counterclockwise)

Preceding gene: 148827104

Following gene: 148827099

Centisome position: 19.86

GC content: 38.56

Gene sequence:

>1014_bases
ATGCAATCCATTCCTATTAAAAACGTAGGAGAGTCTCGCTTAGTCGATCCTTTCCAACGCCAATACTACTATCTGCGACT
GTCGATTACTGATCAGTGTAATTTTCGTTGTACTTATTGTTTACCTGATGGTTATCAACCCGAAGCTAACAAACCGAGTT
TCTTAACCTTAAAAGAAATTACCCATCTTGCTCAAGCCTTTGCTGAAATGGGTACAGAGAAAATCCGTTTAACGGGTGGC
GAACCGACTTTACGCAAAGATTTTATTTCTATTGCTGAAAGCATTACTAACATTGATGGCATTCGTCAATTAGCCGTCAC
GACAAACGGCTATCGCATGGCAAAAGATGTGGCTGATTGGAAGCAAGCAGGGATTACGTCTATTAACGTCAGTGTTGATA
GCCTTGATCCCAAAATGTTCCATCAAATTACAGGTATCAATAAATTTGATGACGTGATGCGTGGTATCGATCGTGCATTT
GAAGTGGGCTACAACAAAGTTAAAGTCAATTCAGTTTTAATGAAAAATCTGAATGATAAAGAATTTGAACAATTTCTCGC
TTGGGTTAAAGATCGCCCAATTCAAATGCGCTTTATCGAACTGATGCAAACGGGCGAAATGGATAGTTTCTTTGATAAAT
TCCATCTTTCAGGACAAGTATTAGCGGATAAATTGCTGAAAAATGGTTGGACATTACAACACAAATCCCATACTGATGGC
CCTGCTAAAGTCTTTACGCATTCTGATTATACTGGTGAAATTGGCTTAATTATGCCTTATGAAAAGAATTTTTGCGCAAG
TTGCAATCGTTTAAGAGTGTCAGCAAAAGGTAAACTTCATCTTTGTTTATTTGGCGAAGAAGGCATTGAATTACGTGATT
TATTGCAGTCGCACGAACAGCAAGGTATTTTACAGGCTCGTATTTTTGCCGCACTTCAAGGCAAACGTGAACATCATTAT
TTGCATATCGGCGATACTGGTGTAAGAAATCATTTAGCTTCTATTGGTGGCTAA

Upstream 100 bases:

>100_bases
CTAAGTTTCATAGAAATACGGTGGCAAGCCAATAACGCGCTACGTTATTCAGGGATACGCTGGAAACGGTTTGTCCTCTC
CGTATTTAGAAAGGTGTAAA

Downstream 100 bases:

>100_bases
AAAGCAAAGTGAGATGAATGGTAATATTCATCTGCTTCCTTTTGTCGCTTATTTAAAACATTCAATATTTTAACCGCACT
TTTATTATATTATGACTACA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADWKQAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EVGYNKVKVNSVLMKNLNDKEFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
PAKVFTHSDYTGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQGILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG

Sequences:

>Translated_337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADWKQAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EVGYNKVKVNSVLMKNLNDKEFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
PAKVFTHSDYTGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQGILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG
>Mature_337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADWKQAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EVGYNKVKVNSVLMKNLNDKEFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
PAKVFTHSDYTGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQGILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=37.9204892966361, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=37.9204892966361, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=61.1620795107034, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI32566331, Length=311, Percent_Identity=36.0128617363344, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=311, Percent_Identity=36.0128617363344, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=312, Percent_Identity=35.8974358974359, Blast_Score=204, Evalue=4e-53,
Organism=Drosophila melanogaster, GI28574490, Length=332, Percent_Identity=36.144578313253, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI28574488, Length=320, Percent_Identity=36.5625, Blast_Score=210, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38325; Mature: 38325

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEI
CCCCCCCCCCCCCCCCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHHH
THLAQAFAEMGTEKIRLTGGEPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADW
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHH
KQAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAFEVGYNKVKVNSVLMKNLNDK
HHCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCHH
EFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCC
PAKVFTHSDYTGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQ
CCEEEECCCCCCCEEEEECCCCCHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
QGILQARIFAALQGKREHHYLHIGDTGVRNHLASIGG
CCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEI
CCCCCCCCCCCCCCCCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHHH
THLAQAFAEMGTEKIRLTGGEPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADW
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHH
KQAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAFEVGYNKVKVNSVLMKNLNDK
HHCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCHH
EFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCC
PAKVFTHSDYTGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQ
CCEEEECCCCCCCEEEEECCCCCHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
QGILQARIFAALQGKREHHYLHIGDTGVRNHLASIGG
CCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA