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The map label for this gene is cobB [H]

Identifier: 148826985

GI number: 148826985

Start: 230047

End: 230880

Strand: Reverse

Name: cobB [H]

Synonym: CGSHiGG_01345

Alternate gene names: 148826985

Gene position: 230880-230047 (Counterclockwise)

Preceding gene: 148826986

Following gene: 148826984

Centisome position: 12.23

GC content: 39.57

Gene sequence:

>834_bases
ATGAAAAATGACTTAAATTATGCAGTGGAACTTATCCGCAAAGCGGATGGCATTTTAATTACAGCTGGTGCGGGTATGAG
CGTGGATTCTGGGCTTCCCGATTTCCGCAGCGTTGGTGGATTTTGGAATGCTTATCCTATGTTTAAAGAACATAATATAT
CTTTTGAAGACATCGCGACGCCACTAGCTTATAAGCATAATCAGGAACTTGCCTATTGGTTTTATGGACATCGATTAGTT
CAATACCGAAATACTCTTCCTCACGAAGGGTATCAGATTTTAAAACGCTGGGCAGGATCTAAATCTCATGGATATTTTGT
TTTTACCAGTAATGTGGATGGGCATTTTCAAAAGGCTGGTTTTAATGATAGCCATGTTTATGAAGTACACGGTACTTTGG
AGCATCTTCAGTGTGTCAATAATTGTCGAGGATTAAGTTGGGCTGCATCAAGTTTTCAACCTGTCGTGGATAATAAAAAC
TTATGTTTAACCAGTGAAAAACCACATTGTCCTTATTGCGGAGGCTTAGCCCGTCAAAATGTGTTGATGTTTGACGATTG
GAGTTATACAAGTCAGTATCAGGATTTCAAAAAGCTACGGTTAGATTCATGGCTAAAAGAAGTTGAGAATTTGGTAGTAA
TTGAGCTAGGTGCGGGCAAAGCAATTCCAACGGTTCGATATTTTTCCGAACGCACGGCAAAAGCCAAGAAAGCCGGTTTT
ATTCGCATTAATCCGCAAGACGGTGGCGTATCAAAACATCATTTTTTAGGGCTGGATATGACCGCACTTGAGGCTTTAAA
AGCAATAGATGCTTTATTGAATCAATCAACATAA

Upstream 100 bases:

>100_bases
GCAGATTTATGTTGGGTTTTAATCGAGCTGGGCAAATTTTAGAACAGTTGGAACAAGCGGGTATTATTTCATCAATGAAA
AATGGACAGAGAAAAGTATT

Downstream 100 bases:

>100_bases
GGAAACCAATATGAAAAATCTCTGCCAAATTACTTTTTGTCAGCAAATTGGAAAAAATAAAAGGCACAATCAAGATGCGT
TATTTAATGGTGAAACGGTT

Product: NAD-dependent deacetylase sirtuin 5

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKNDLNYAVELIRKADGILITAGAGMSVDSGLPDFRSVGGFWNAYPMFKEHNISFEDIATPLAYKHNQELAYWFYGHRLV
QYRNTLPHEGYQILKRWAGSKSHGYFVFTSNVDGHFQKAGFNDSHVYEVHGTLEHLQCVNNCRGLSWAASSFQPVVDNKN
LCLTSEKPHCPYCGGLARQNVLMFDDWSYTSQYQDFKKLRLDSWLKEVENLVVIELGAGKAIPTVRYFSERTAKAKKAGF
IRINPQDGGVSKHHFLGLDMTALEALKAIDALLNQST

Sequences:

>Translated_277_residues
MKNDLNYAVELIRKADGILITAGAGMSVDSGLPDFRSVGGFWNAYPMFKEHNISFEDIATPLAYKHNQELAYWFYGHRLV
QYRNTLPHEGYQILKRWAGSKSHGYFVFTSNVDGHFQKAGFNDSHVYEVHGTLEHLQCVNNCRGLSWAASSFQPVVDNKN
LCLTSEKPHCPYCGGLARQNVLMFDDWSYTSQYQDFKKLRLDSWLKEVENLVVIELGAGKAIPTVRYFSERTAKAKKAGF
IRINPQDGGVSKHHFLGLDMTALEALKAIDALLNQST
>Mature_277_residues
MKNDLNYAVELIRKADGILITAGAGMSVDSGLPDFRSVGGFWNAYPMFKEHNISFEDIATPLAYKHNQELAYWFYGHRLV
QYRNTLPHEGYQILKRWAGSKSHGYFVFTSNVDGHFQKAGFNDSHVYEVHGTLEHLQCVNNCRGLSWAASSFQPVVDNKN
LCLTSEKPHCPYCGGLARQNVLMFDDWSYTSQYQDFKKLRLDSWLKEVENLVVIELGAGKAIPTVRYFSERTAKAKKAGF
IRINPQDGGVSKHHFLGLDMTALEALKAIDALLNQST

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=190, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI6912664, Length=190, Percent_Identity=30, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI300795542, Length=176, Percent_Identity=30.1136363636364, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI308199517, Length=132, Percent_Identity=28.7878787878788, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31305; Mature: 31305

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNDLNYAVELIRKADGILITAGAGMSVDSGLPDFRSVGGFWNAYPMFKEHNISFEDIAT
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCHHCCCCCHHHHHC
PLAYKHNQELAYWFYGHRLVQYRNTLPHEGYQILKRWAGSKSHGYFVFTSNVDGHFQKAG
CHHHCCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCC
FNDSHVYEVHGTLEHLQCVNNCRGLSWAASSFQPVVDNKNLCLTSEKPHCPYCGGLARQN
CCCCEEEEECCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCC
VLMFDDWSYTSQYQDFKKLRLDSWLKEVENLVVIELGAGKAIPTVRYFSERTAKAKKAGF
EEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCE
IRINPQDGGVSKHHFLGLDMTALEALKAIDALLNQST
EEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKNDLNYAVELIRKADGILITAGAGMSVDSGLPDFRSVGGFWNAYPMFKEHNISFEDIAT
CCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHCCCCCCCCCHHCCCCCHHHHHC
PLAYKHNQELAYWFYGHRLVQYRNTLPHEGYQILKRWAGSKSHGYFVFTSNVDGHFQKAG
CHHHCCCCCEEEEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCC
FNDSHVYEVHGTLEHLQCVNNCRGLSWAASSFQPVVDNKNLCLTSEKPHCPYCGGLARQN
CCCCEEEEECCHHHHHHHHHHCCCCEECCCCCCCCCCCCCEEEECCCCCCCCCCCHHHCC
VLMFDDWSYTSQYQDFKKLRLDSWLKEVENLVVIELGAGKAIPTVRYFSERTAKAKKAGF
EEEEECCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCE
IRINPQDGGVSKHHFLGLDMTALEALKAIDALLNQST
EEECCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]