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The map label for this gene is folP-A [H]

Identifier: 148826965

GI number: 148826965

Start: 204260

End: 205087

Strand: Reverse

Name: folP-A [H]

Synonym: CGSHiGG_01215

Alternate gene names: 148826965

Gene position: 205087-204260 (Counterclockwise)

Preceding gene: 148826966

Following gene: 148826964

Centisome position: 10.87

GC content: 39.61

Gene sequence:

>828_bases
ATGAAACTTTACGCAAATAATAAATGTCTTGATTTAAGCGTGCCTCAAATTATGGGGATTCTTAATTTTACGCCTGATTC
TTTTTCTGATAGCGGACAGTTTTTTAGTCTAGATAAAGCACTTTTTCAAGTTGAAAAAATGCTAGAAGAGGGGGCGACAA
TTATTGATATTGGTGGAGAATCCACTCGTCCGAATGCGGATGAAGTTTCTGAACAAGAGGAATTGCATCGTGTTTTACCA
GTAGTGGAGGCGGTGCGAAACCGTTTTGATTGCTGGATTTCTGTTGATTCCTCAAAAGCAATTGTGATGCGTGAAGCGGC
AAATGTTGGAATGGATTTGATTAATGATATTCGTGCTTTGCAAGAGCCGAATGCGTTAGAAACGGCGGTAAAACTGGCTT
TACCTGTTTGTATTATGCATATGCAAGGGCAACCTCGCACGATGCAAGCAAATCCTTATTATGAAAATGTCGTGCAAGAT
GTATTGGCTTTTTTACAAAAACGTACTAATGAATGCCTTTCTGCTGGCATTAAAAAAGAAAATTTAATTTGGGATATGGG
CTTTGGCTTTGGCAAATCTGTACAGCATAATTATCAATTATTACAAAATCTGAATGAATTTTGTCTGAATGGTTATCCCG
TATTAGCAGGATTATCTCGCAAATCAATGATTGGCGCAGTGCTTGAGAAACCCATCGATCAGCGAGTGATTGGCAGTGCG
GCAGGTGCGCTTATTGCAGTGCAAAAAGGTGCAAAAATTTTACGCGTACATGATGTTGCTGCAACATCAGATATGCTCAA
AGTTTGGCAGGCAACAGCAAATGCCTGA

Upstream 100 bases:

>100_bases
CTTTCTTCGGAAAGGCTTTATTTTTTCCTAATGATTTTGTTCTTGGATGTATTTCGCTATAATCGCCCACCAAAATCACT
CTAAAAATTAACCGCACTTT

Downstream 100 bases:

>100_bases
TGGTTTTATAACGATAAAAAATTAAAGGAATTTTATTATGGTAAATCGTAAATATTTTGGAACAGATGGTGTACGTGGAA
AAGTAGGTGCTTACCCAATT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVLP
VVEAVRNRFDCWISVDSSKAIVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQD
VLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCLNGYPVLAGLSRKSMIGAVLEKPIDQRVIGSA
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA

Sequences:

>Translated_275_residues
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVLP
VVEAVRNRFDCWISVDSSKAIVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQD
VLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCLNGYPVLAGLSRKSMIGAVLEKPIDQRVIGSA
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA
>Mature_275_residues
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGESTRPNADEVSEQEELHRVLP
VVEAVRNRFDCWISVDSSKAIVMREAANVGMDLINDIRALQEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQD
VLAFLQKRTNECLSAGIKKENLIWDMGFGFGKSVQHNYQLLQNLNEFCLNGYPVLAGLSRKSMIGAVLEKPIDQRVIGSA
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=275, Percent_Identity=54.5454545454545, Blast_Score=301, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6324073, Length=321, Percent_Identity=28.3489096573209, Blast_Score=122, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30358; Mature: 30358

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGE
CEEECCCCEEECCHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEECCC
STRPNADEVSEQEELHRVLPVVEAVRNRFDCWISVDSSKAIVMREAANVGMDLINDIRAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHCCHHHHHHHHHH
QEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQDVLAFLQKRTNECLSAGIKKE
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NLIWDMGFGFGKSVQHNYQLLQNLNEFCLNGYPVLAGLSRKSMIGAVLEKPIDQRVIGSA
CEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCHHHHHHHHH
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA
HHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLYANNKCLDLSVPQIMGILNFTPDSFSDSGQFFSLDKALFQVEKMLEEGATIIDIGGE
CEEECCCCEEECCHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEECCC
STRPNADEVSEQEELHRVLPVVEAVRNRFDCWISVDSSKAIVMREAANVGMDLINDIRAL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEHHHHHCCHHHHHHHHHH
QEPNALETAVKLALPVCIMHMQGQPRTMQANPYYENVVQDVLAFLQKRTNECLSAGIKKE
CCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
NLIWDMGFGFGKSVQHNYQLLQNLNEFCLNGYPVLAGLSRKSMIGAVLEKPIDQRVIGSA
CEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCHHHHHHHHH
AGALIAVQKGAKILRVHDVAATSDMLKVWQATANA
HHHHEEECCCCEEEEEHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]