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The map label for this gene is msrAB [H]

Identifier: 148826956

GI number: 148826956

Start: 196361

End: 197422

Strand: Reverse

Name: msrAB [H]

Synonym: CGSHiGG_01150

Alternate gene names: 148826956

Gene position: 197422-196361 (Counterclockwise)

Preceding gene: 148826958

Following gene: 148826955

Centisome position: 10.46

GC content: 37.19

Gene sequence:

>1062_bases
ATGAAACTATCAAAAACATTTCTATTTATTACCGCACTTTGCTGTGCAGCACCAACTTTAGCAATACAAAATTCAACATC
ATCATCTGGAGAACAAAAAATGGCAATGGAAAATACACAAAACATTCGAGAAATTTATCTTGCTGGTGGCTGTTTTTGGG
GTATGGAAGCATATATGGAGCGTATTCACGGTGTGAAAGATGCGATTTCTGGCTATGCCAATGGTAATACAGGGAAAACC
AGTTATCATATGATTGGGCTAACTGATCACGCAGAAACGGTAAAAGTCACTTACGATGCAAACCAAATTTCGTTAGATAA
ATTGCTTAAATATTATTTTAAAGTGATTGATCCAACGAGTGTAAACAAACAAGGTAACGATCGTGGTAGACAATATCGCA
CAGGGATTTATTATCAAGATGGGGCAGATAAAGCAGTGATCGAACAAGCTCTCGCCCAGCTTCAAACCAAATATAAAAAA
CCAGTGCAAGTTGAGGTACAACCGATTAAAAATTACATCGTAGCGGAAGAATATCATCAAGATTATTTGAAGAAAAATCC
AAATGGTTATTGCCATATTGATATTACCAAAGCAGATGAACCTGTGATTGATGAAAAAGATTATCCGAAACCGAGTGATG
CGGAACTCAAAGCGAAATTGACACCGTTGCAATATTCCGTTACTCAAAATAAACATACTGAACGCTCTTTTAGTAACGAA
TATTGGGATAACTTCCAACCTGGTATTTATGTTGATGTCACTACAGGCGAGCCTGTTTTCTCTTCAAATGATAAATTTGA
ATCAGGTTGTGGCTGGCCAAGTTTTACGAAACCGATCATTAAAGATGTAGTGCATTATGAAACCGACAACAGCTTCAATA
TGCAACGTACCGAGGTGTTAAGTCGTGCGGGCAATGCCCATTTAGGTCACGTTTTTGATGACGGTCCGAAAGATAAAGGC
GGTTTGCGTTATTGCATTAACAGTGCATCAATTAAATTTATTCCGTTAGCAGAAATGGAAAAGGCAGGATATGGATATTT
GATTCAATCCATTAAAAAATAA

Upstream 100 bases:

>100_bases
TAATCAATTTCTTTAAAAATTTTGCAAAAATCTGTAAGAAATCGAATTATCCGCCGTCTAACCTTATGTAACGTTAATTT
TTACATCATAAGGAAAAGCA

Downstream 100 bases:

>100_bases
GGAGATGTAGGATGTTAGATCAACAACTCCTTATTGGAACTGTATTTTTAGCGGGGCTTGCTTCTTTTCTTTCGCCTTGT
ATTTTCCCGATTATTCCAAT

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKLSKTFLFITALCCAAPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYMERIHGVKDAISGYANGNTGKT
SYHMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTSVNKQGNDRGRQYRTGIYYQDGADKAVIEQALAQLQTKYKK
PVQVEVQPIKNYIVAEEYHQDYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
YWDNFQPGIYVDVTTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVLSRAGNAHLGHVFDDGPKDKG
GLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK

Sequences:

>Translated_353_residues
MKLSKTFLFITALCCAAPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYMERIHGVKDAISGYANGNTGKT
SYHMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTSVNKQGNDRGRQYRTGIYYQDGADKAVIEQALAQLQTKYKK
PVQVEVQPIKNYIVAEEYHQDYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
YWDNFQPGIYVDVTTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVLSRAGNAHLGHVFDDGPKDKG
GLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK
>Mature_353_residues
MKLSKTFLFITALCCAAPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYMERIHGVKDAISGYANGNTGKT
SYHMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTSVNKQGNDRGRQYRTGIYYQDGADKAVIEQALAQLQTKYKK
PVQVEVQPIKNYIVAEEYHQDYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
YWDNFQPGIYVDVTTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVLSRAGNAHLGHVFDDGPKDKG
GLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=50, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=50, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=50, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=50, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI6912516, Length=163, Percent_Identity=36.8098159509202, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI208609995, Length=163, Percent_Identity=36.8098159509202, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI117606353, Length=131, Percent_Identity=43.5114503816794, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI208609993, Length=123, Percent_Identity=38.2113821138211, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=45.9677419354839, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790665, Length=161, Percent_Identity=36.6459627329193, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17553450, Length=130, Percent_Identity=40, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=130, Percent_Identity=40, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=29.0780141843972, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=40.7643312101911, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=34.6153846153846, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221378664, Length=129, Percent_Identity=46.5116279069767, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553335, Length=121, Percent_Identity=47.1074380165289, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21356369, Length=121, Percent_Identity=47.1074380165289, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24645799, Length=121, Percent_Identity=47.1074380165289, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI221378662, Length=136, Percent_Identity=44.1176470588235, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24645804, Length=132, Percent_Identity=43.1818181818182, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645801, Length=132, Percent_Identity=43.1818181818182, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 39815; Mature: 39815

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSKTFLFITALCCAAPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYME
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHH
RIHGVKDAISGYANGNTGKTSYHMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTS
HHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCEECHHHHHHHHHHHCCCCC
VNKQGNDRGRQYRTGIYYQDGADKAVIEQALAQLQTKYKKPVQVEVQPIKNYIVAEEYHQ
CCCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHH
DYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHCHH
YWDNFQPGIYVDVTTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVL
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
SRAGNAHLGHVFDDGPKDKGGLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MKLSKTFLFITALCCAAPTLAIQNSTSSSGEQKMAMENTQNIREIYLAGGCFWGMEAYME
CCCCHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHEEEEEECCHHHHHHHHHH
RIHGVKDAISGYANGNTGKTSYHMIGLTDHAETVKVTYDANQISLDKLLKYYFKVIDPTS
HHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCEECHHHHHHHHHHHCCCCC
VNKQGNDRGRQYRTGIYYQDGADKAVIEQALAQLQTKYKKPVQVEVQPIKNYIVAEEYHQ
CCCCCCCCCCEEECCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHH
DYLKKNPNGYCHIDITKADEPVIDEKDYPKPSDAELKAKLTPLQYSVTQNKHTERSFSNE
HHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCEEEEECCCCCHHHHHCHH
YWDNFQPGIYVDVTTGEPVFSSNDKFESGCGWPSFTKPIIKDVVHYETDNSFNMQRTEVL
HHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
SRAGNAHLGHVFDDGPKDKGGLRYCINSASIKFIPLAEMEKAGYGYLIQSIKK
HHCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]