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The map label for this gene is ispA [H]

Identifier: 148826941

GI number: 148826941

Start: 184405

End: 185295

Strand: Direct

Name: ispA [H]

Synonym: CGSHiGG_01075

Alternate gene names: 148826941

Gene position: 184405-185295 (Clockwise)

Preceding gene: 148826940

Following gene: 148826942

Centisome position: 9.77

GC content: 37.26

Gene sequence:

>891_bases
ATGGGTCACTTTTCTGAAGAATTACAACAGGTTCAAAATCGTATTAATCACTTTTTAGAAGCTCAATTTGAGGGCATTGA
AAGTCATAATGCACCTTTGCTTAACGCGATGAAATACGCATTATTACTTGGTGGTAAACGAGTTAGACCTTTTTTGGTTT
ACGCAACTGGTCAAATGCTTGGTGCAGAGAAACAAACCTTAGATTACGTCGCTGCTGCCATTGAAGCTATTCACGCCTAT
TCCTTAATTCACGATGATTTACCTGCGATGGACGATGACAATCTACGTCGTGGACATCCTACTTGTCATATCCAATTTGA
TGAAGCTACAGCTATTCTTGCGGGCGATGCACTACAAAGTTTCGCATTTGAAATATTAACCAAAACTCCGAATATTTCTG
CTGAACAAAAACTGGCTTTAGTTCAAATTTTAGCTCAAGGCTCAGGCGTACAAGGAATGTGCTTAGGGCAAAGTTTAGAT
CTTATTTCTGAACATAAACAAATTAGTTTAAGCGAATTAGAATTAATCCATCGTAACAAAACGGGCGCGTTGCTAATTGC
CGCATTGAAATTAGGTTTCATTTGTTCTCCGCATTTTACCGACAAAAAGTTAGAACAATCCTTAACACAATATGCGGAAG
CCATTGGCTTAGCCTTTCAAGTTCAAGATGATATTTTAGATATTGAAGGCGATAGTGCAGAAATTGGCAAACAAGTCGGT
GCCGATCTTGATTTAGATAAAAGTACATATCCAAAATTACTTGGGTTAAGTGGCGCAAAACAAAAAGCACAAGATCTATA
TCAAAGTGCTTTGTCTGAATTAGAAAAAATTCCTTTTAATACGACCGCACTTCGTGCATTAGCTGAATTCATTATTACCA
GAAAAAGTTAA

Upstream 100 bases:

>100_bases
AGTTAGGGCAAGAACGTTTACAACAAGCAGAACAACGTATTCAGATCTTATTGCAAAAAACAGAAGATGCTCCACTGAAT
GATTATAAAGGGAATGCTTA

Downstream 100 bases:

>100_bases
ACACTCACAAAAGTGCGGTCAAAATTTATAACGTTTTTAAAATGACTAACAATATGAACAATTATCCTCTTTTATCTTTA
ATTAATTCTCCAGAAGATTT

Product: exodeoxyribonuclease VII small subunit

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MGHFSEELQQVQNRINHFLEAQFEGIESHNAPLLNAMKYALLLGGKRVRPFLVYATGQMLGAEKQTLDYVAAAIEAIHAY
SLIHDDLPAMDDDNLRRGHPTCHIQFDEATAILAGDALQSFAFEILTKTPNISAEQKLALVQILAQGSGVQGMCLGQSLD
LISEHKQISLSELELIHRNKTGALLIAALKLGFICSPHFTDKKLEQSLTQYAEAIGLAFQVQDDILDIEGDSAEIGKQVG
ADLDLDKSTYPKLLGLSGAKQKAQDLYQSALSELEKIPFNTTALRALAEFIITRKS

Sequences:

>Translated_296_residues
MGHFSEELQQVQNRINHFLEAQFEGIESHNAPLLNAMKYALLLGGKRVRPFLVYATGQMLGAEKQTLDYVAAAIEAIHAY
SLIHDDLPAMDDDNLRRGHPTCHIQFDEATAILAGDALQSFAFEILTKTPNISAEQKLALVQILAQGSGVQGMCLGQSLD
LISEHKQISLSELELIHRNKTGALLIAALKLGFICSPHFTDKKLEQSLTQYAEAIGLAFQVQDDILDIEGDSAEIGKQVG
ADLDLDKSTYPKLLGLSGAKQKAQDLYQSALSELEKIPFNTTALRALAEFIITRKS
>Mature_295_residues
GHFSEELQQVQNRINHFLEAQFEGIESHNAPLLNAMKYALLLGGKRVRPFLVYATGQMLGAEKQTLDYVAAAIEAIHAYS
LIHDDLPAMDDDNLRRGHPTCHIQFDEATAILAGDALQSFAFEILTKTPNISAEQKLALVQILAQGSGVQGMCLGQSLDL
ISEHKQISLSELELIHRNKTGALLIAALKLGFICSPHFTDKKLEQSLTQYAEAIGLAFQVQDDILDIEGDSAEIGKQVGA
DLDLDKSTYPKLLGLSGAKQKAQDLYQSALSELEKIPFNTTALRALAEFIITRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=220, Percent_Identity=29.5454545454545, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786623, Length=297, Percent_Identity=52.8619528619529, Blast_Score=274, Evalue=4e-75,
Organism=Escherichia coli, GI1789578, Length=238, Percent_Identity=31.5126050420168, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17505681, Length=288, Percent_Identity=27.0833333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24651612, Length=219, Percent_Identity=29.6803652968037, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32442; Mature: 32311

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHFSEELQQVQNRINHFLEAQFEGIESHNAPLLNAMKYALLLGGKRVRPFLVYATGQML
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHH
GAEKQTLDYVAAAIEAIHAYSLIHDDLPAMDDDNLRRGHPTCHIQFDEATAILAGDALQS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHH
FAFEILTKTPNISAEQKLALVQILAQGSGVQGMCLGQSLDLISEHKQISLSELELIHRNK
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHCCC
TGALLIAALKLGFICSPHFTDKKLEQSLTQYAEAIGLAFQVQDDILDIEGDSAEIGKQVG
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCEEECCCCHHHHHHHHC
ADLDLDKSTYPKLLGLSGAKQKAQDLYQSALSELEKIPFNTTALRALAEFIITRKS
CCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GHFSEELQQVQNRINHFLEAQFEGIESHNAPLLNAMKYALLLGGKRVRPFLVYATGQML
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHH
GAEKQTLDYVAAAIEAIHAYSLIHDDLPAMDDDNLRRGHPTCHIQFDEATAILAGDALQS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHH
FAFEILTKTPNISAEQKLALVQILAQGSGVQGMCLGQSLDLISEHKQISLSELELIHRNK
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHCCC
TGALLIAALKLGFICSPHFTDKKLEQSLTQYAEAIGLAFQVQDDILDIEGDSAEIGKQVG
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCEEECCCCHHHHHHHHC
ADLDLDKSTYPKLLGLSGAKQKAQDLYQSALSELEKIPFNTTALRALAEFIITRKS
CCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]