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The map label for this gene is pyrD [H]

Identifier: 148826884

GI number: 148826884

Start: 145209

End: 146228

Strand: Reverse

Name: pyrD [H]

Synonym: CGSHiGG_00770

Alternate gene names: 148826884

Gene position: 146228-145209 (Counterclockwise)

Preceding gene: 148826885

Following gene: 148826883

Centisome position: 7.75

GC content: 37.94

Gene sequence:

>1020_bases
ATGTATCAATTATTCCGTCACGGCATTTTCCAAATGGATGCTGAAAAGGCTCATGATTTCACGATTCAATGCTTGAAATT
AGCTGGTAATCCTTTATTTCAACCTATCTTAAAATCTCTTATTCATGCTCCCAAAGGCTTTCCGAAAACGGTAATGGGTG
TGAATTTCCCTAATCCCATTGGATTGGCGGCAGGGGCAGATAAAAATGGCGATGCTATTGATGGTTTCGGTGCATTAGGT
TTTGGTTTTCTCGAGGTAGGAACAGTCACGCCCGTTGCACAAGATGGGAATGCAAAGCCACGTCAGTTTCGTTTGATTGA
AGCTGAAGGCATTATTAACCGTAATGGCTTTAATAATAATGGCATAGACTATCTTATAGAAAATGTGAAAAACGCCCGTT
ATAAAGGTGTGATAGGCATCAATATTGGTAAAAATAAATTCACACCTTTGGAACAAGGCAAAGATGATTATATTTTCTGT
TTGAACAAAGCCTATAACTATGCAGGTTATATTACGGTGAATATTTCATCTCCCAATACACCAGATTTGCGTCAATTACA
ATATGGTGATTATTTCGATGATTTATTGCGAAGCATCAAGGATCGTCAGGCTATTTTGGCAAACCAATACAATAAATATG
TGCCGATTGCGGTAAAAATTGCACCAGATTTAACGGAAAGTGAATTAGTGCAAATTGCGGATACATTGGTTCGTCATAAA
ATGGATGGCGTTATTGCAACGAATACTACAATTTCTCGTGATACTGTGATGGGGATGAAAAATGCCGAACAGCAAGGCGG
ATTAAGTGGAAAGCCGTTGCAGCATAAAAGCACGGAGATTATTAAGCGATTACATCAAGAACTGAAAGGTCAGATTCCCA
TTATTGGTAGCGGTGGCATTGATGGTTTGCAAAATGCACAAGAGAAAATTGAGGCTGGTGCCGAGTTGTTGCAAGTTTAT
TCAGGATTGATTTATCACGGTCCAAAATTAGTAAAAGAATTAGTAAAAAATATTAAATAA

Upstream 100 bases:

>100_bases
ATTTTTGTTCCTCGTAGAATACGAGCAACCTTACCTTTAAAGTGCGGTGAAAATTGACCGTACTTTTCTTACAGTAAACT
ATCCCGAGAGATAAACGAAT

Downstream 100 bases:

>100_bases
TGACAAAAAAATACGACTTACATTGTCATAGTACCGCATCAGATGGAGTGTTGAGTCCAACTGAATTAGTGCATCGTGCT
TATGCGCAAGGTGTGAACGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MYQLFRHGIFQMDAEKAHDFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPIGLAAGADKNGDAIDGFGALG
FGFLEVGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNGIDYLIENVKNARYKGVIGINIGKNKFTPLEQGKDDYIFC
LNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
MDGVIATNTTISRDTVMGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVY
SGLIYHGPKLVKELVKNIK

Sequences:

>Translated_339_residues
MYQLFRHGIFQMDAEKAHDFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPIGLAAGADKNGDAIDGFGALG
FGFLEVGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNGIDYLIENVKNARYKGVIGINIGKNKFTPLEQGKDDYIFC
LNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
MDGVIATNTTISRDTVMGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVY
SGLIYHGPKLVKELVKNIK
>Mature_339_residues
MYQLFRHGIFQMDAEKAHDFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPIGLAAGADKNGDAIDGFGALG
FGFLEVGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNNGIDYLIENVKNARYKGVIGINIGKNKFTPLEQGKDDYIFC
LNKAYNYAGYITVNISSPNTPDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
MDGVIATNTTISRDTVMGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGIDGLQNAQEKIEAGAELLQVY
SGLIYHGPKLVKELVKNIK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=36.9047619047619, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI1787177, Length=338, Percent_Identity=60.9467455621302, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17509475, Length=344, Percent_Identity=39.8255813953488, Blast_Score=230, Evalue=7e-61,
Organism=Drosophila melanogaster, GI281361352, Length=344, Percent_Identity=41.5697674418605, Blast_Score=250, Evalue=8e-67,
Organism=Drosophila melanogaster, GI17137316, Length=344, Percent_Identity=41.5697674418605, Blast_Score=250, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 37298; Mature: 37298

Theoretical pI: Translated: 9.09; Mature: 9.09

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQLFRHGIFQMDAEKAHDFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPI
CCCHHHCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCC
GLAAGADKNGDAIDGFGALGFGFLEVGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNN
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEECCCCCCC
GIDYLIENVKNARYKGVIGINIGKNKFTPLEQGKDDYIFCLNKAYNYAGYITVNISSPNT
CHHHHHHHHCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEEECCCCCEEEEEEEECCCCC
PDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
CCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHH
MDGVIATNTTISRDTVMGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGI
HCCEEEECCEECHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
DGLQNAQEKIEAGAELLQVYSGLIYHGPKLVKELVKNIK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MYQLFRHGIFQMDAEKAHDFTIQCLKLAGNPLFQPILKSLIHAPKGFPKTVMGVNFPNPI
CCCHHHCCHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCC
GLAAGADKNGDAIDGFGALGFGFLEVGTVTPVAQDGNAKPRQFRLIEAEGIINRNGFNNN
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCEEECCCCCCC
GIDYLIENVKNARYKGVIGINIGKNKFTPLEQGKDDYIFCLNKAYNYAGYITVNISSPNT
CHHHHHHHHCCCCCCEEEEEEECCCCCCHHHCCCCCEEEEEECCCCCEEEEEEEECCCCC
PDLRQLQYGDYFDDLLRSIKDRQAILANQYNKYVPIAVKIAPDLTESELVQIADTLVRHK
CCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHH
MDGVIATNTTISRDTVMGMKNAEQQGGLSGKPLQHKSTEIIKRLHQELKGQIPIIGSGGI
HCCEEEECCEECHHHHHCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
DGLQNAQEKIEAGAELLQVYSGLIYHGPKLVKELVKNIK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA