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The map label for this gene is fumC [H]

Identifier: 148826881

GI number: 148826881

Start: 142156

End: 143550

Strand: Direct

Name: fumC [H]

Synonym: CGSHiGG_00755

Alternate gene names: 148826881

Gene position: 142156-143550 (Clockwise)

Preceding gene: 148826874

Following gene: 148826882

Centisome position: 7.53

GC content: 39.35

Gene sequence:

>1395_bases
ATGGCATTTCGTATTGAAAAAGACACAATGGGTGAAGTTCAAGTTCCAGCAGATAAATACTGGGCTGCACAAACTGAACG
TTCACGCAATAACTTTAAAATTGGTTCAGCCGCATCAATGCCACATGAAATTATCGAAGCTTTTGGCTATTTGAAAAAAG
CAGCCGCATTTGCTAATCATGATTTAGGTGTATTACCTCTTGAAAAACGTGATTTAATTGCTCTGGCTTGTGACGAAATT
TTAGCAAATAAATTAGATGATCAATTCCCACTTGTTATTTGGCAAACTGGTTCTGGCACACAATCCAATATGAATGTGAA
TGAAGTGGTTGCCAATCGTGGACATGTGATAAACGGTGGAAAATTAGGCGAAAAATCAATCATTCATCCAAATGACGATG
TGAACAAATCACAATCTTCAAATGATACTTTCCCAACGGCAATGCACATTGCGGCATATAAAAAAGTAGTTGAGCACACC
ATTCCTTGTGTTGAACGTTTACAAAAAACTTTTGCGGCAAAATCTGAAGCCTTCAAAAACGTGGTAAAAATTGGCCGCAC
TCACTTAATGGATGCAACGCCACTCACATTAGGTCAAGAATTTTCGGCTTATGCGGCTCAATTAGATTTCGGCTTAAAAG
CATTAAAAAATACGCTGCCACATTTAAGCCAATTAGCATTGGGTGGAACTGCGGTTGGCACAGGTTTGAACACGCCGAAA
GGCTATGATGTGAAAGTGGCAGATTACATTGCAAAATTCACCGCACTTCCGTTTGTCACAGCAGATAATAAATTTGAAGC
ATTAGCCGCTCATGATGCGATTGTTGAAACTCACGGTGCATTACGTCAATTAGCAATGAGTTTATTTAAAATTGCGAACG
ATATTCGTCTATTAGCATCAGGCCCTCGTTCGGGAATTGGCGAAATTTTAATTCCTGAAAATGAACCAGGTTCTTCAATT
ATGCCAGGTAAAGTAAACCCAACTCAATGCGAAGCGATGACAATGGTCTGCGCACAAGTATTTGGTAATGACACTACAAT
CGCATTTGTGGGTTCACAAGGTCACTTCCAATTAAATGTGTTCAACCCTGTGATGATTGCAAACTTCTTACAATCTGCTC
AATTATTGGGCGATGCTTGCGTATCTTTCGATGAACACTGTGCAGTGGGTATTGAGCCAAACTATCCACGCATTAAACAA
CAACTTGAAAATTCATTGATGTTGGTGACCGCACTTAATACGCATATCGGTTATGAAAATGCAGCTAAAATTGCAAAAAC
CGCACATAAAAATGGCACCACATTACGTGAAGAAGCGATTAATTTAGGTTTAGTGTCTGCCGAAGATTTTGATAAATGGG
TTCGCCCAGAAGATATGGTGGGTAGCTTAAAATAA

Upstream 100 bases:

>100_bases
ACAAAACTGATTTTTAACGTTTTTGTTACGTTCCACTCATAACTCGGAAGTGTTAAAATCACTTGCGTTTTAATTTTCAT
TCAATTCATAGGAGTACAGA

Downstream 100 bases:

>100_bases
TTCATCGCACAAATTAACATTACAACGATCAAAGGCGAGTAAAATTACTCGCCTTTTTACTGATTTCTAATTTGCTTTTT
GATGCGGTTTGTTATAATCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGSAASMPHEIIEAFGYLKKAAAFANHDLGVLPLEKRDLIALACDEI
LANKLDDQFPLVIWQTGSGTQSNMNVNEVVANRGHVINGGKLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAAYKKVVEHT
IPCVERLQKTFAAKSEAFKNVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLKALKNTLPHLSQLALGGTAVGTGLNTPK
GYDVKVADYIAKFTALPFVTADNKFEALAAHDAIVETHGALRQLAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVCAQVFGNDTTIAFVGSQGHFQLNVFNPVMIANFLQSAQLLGDACVSFDEHCAVGIEPNYPRIKQ
QLENSLMLVTALNTHIGYENAAKIAKTAHKNGTTLREEAINLGLVSAEDFDKWVRPEDMVGSLK

Sequences:

>Translated_464_residues
MAFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGSAASMPHEIIEAFGYLKKAAAFANHDLGVLPLEKRDLIALACDEI
LANKLDDQFPLVIWQTGSGTQSNMNVNEVVANRGHVINGGKLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAAYKKVVEHT
IPCVERLQKTFAAKSEAFKNVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLKALKNTLPHLSQLALGGTAVGTGLNTPK
GYDVKVADYIAKFTALPFVTADNKFEALAAHDAIVETHGALRQLAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSI
MPGKVNPTQCEAMTMVCAQVFGNDTTIAFVGSQGHFQLNVFNPVMIANFLQSAQLLGDACVSFDEHCAVGIEPNYPRIKQ
QLENSLMLVTALNTHIGYENAAKIAKTAHKNGTTLREEAINLGLVSAEDFDKWVRPEDMVGSLK
>Mature_463_residues
AFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGSAASMPHEIIEAFGYLKKAAAFANHDLGVLPLEKRDLIALACDEIL
ANKLDDQFPLVIWQTGSGTQSNMNVNEVVANRGHVINGGKLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAAYKKVVEHTI
PCVERLQKTFAAKSEAFKNVVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLKALKNTLPHLSQLALGGTAVGTGLNTPKG
YDVKVADYIAKFTALPFVTADNKFEALAAHDAIVETHGALRQLAMSLFKIANDIRLLASGPRSGIGEILIPENEPGSSIM
PGKVNPTQCEAMTMVCAQVFGNDTTIAFVGSQGHFQLNVFNPVMIANFLQSAQLLGDACVSFDEHCAVGIEPNYPRIKQQ
LENSLMLVTALNTHIGYENAAKIAKTAHKNGTTLREEAINLGLVSAEDFDKWVRPEDMVGSLK

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=62.0390455531453, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI266458395, Length=87, Percent_Identity=47.1264367816092, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1787896, Length=461, Percent_Identity=62.472885032538, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=40.5639913232104, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=462, Percent_Identity=61.2554112554113, Blast_Score=580, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=62.4615384615385, Blast_Score=428, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=60.3036876355748, Blast_Score=556, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24640179, Length=461, Percent_Identity=59.8698481561822, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24640177, Length=461, Percent_Identity=59.8698481561822, Blast_Score=564, Evalue=1e-161,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=58.6580086580087, Blast_Score=556, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=56.8329718004338, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=50.9761388286334, Blast_Score=457, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50360; Mature: 50229

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGSAASMPHEIIEAFGYLKKAAAFANH
CCEEECCCCCCCEECCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCC
DLGVLPLEKRDLIALACDEILANKLDDQFPLVIWQTGSGTQSNMNVNEVVANRGHVINGG
CCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEECCC
KLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAAYKKVVEHTIPCVERLQKTFAAKSEAFKN
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLKALKNTLPHLSQLALGGTAVGTGLNTPK
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GYDVKVADYIAKFTALPFVTADNKFEALAAHDAIVETHGALRQLAMSLFKIANDIRLLAS
CCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVCAQVFGNDTTIAFVGSQGHFQLNV
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEE
FNPVMIANFLQSAQLLGDACVSFDEHCAVGIEPNYPRIKQQLENSLMLVTALNTHIGYEN
CCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCEEEEEEHHHHCCCHH
AAKIAKTAHKNGTTLREEAINLGLVSAEDFDKWVRPEDMVGSLK
HHHHHHHHCCCCCHHHHHHHHCCEECHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure 
AFRIEKDTMGEVQVPADKYWAAQTERSRNNFKIGSAASMPHEIIEAFGYLKKAAAFANH
CEEECCCCCCCEECCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHCC
DLGVLPLEKRDLIALACDEILANKLDDQFPLVIWQTGSGTQSNMNVNEVVANRGHVINGG
CCCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEECCC
KLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAAYKKVVEHTIPCVERLQKTFAAKSEAFKN
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVKIGRTHLMDATPLTLGQEFSAYAAQLDFGLKALKNTLPHLSQLALGGTAVGTGLNTPK
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCC
GYDVKVADYIAKFTALPFVTADNKFEALAAHDAIVETHGALRQLAMSLFKIANDIRLLAS
CCCCHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEC
GPRSGIGEILIPENEPGSSIMPGKVNPTQCEAMTMVCAQVFGNDTTIAFVGSQGHFQLNV
CCCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEE
FNPVMIANFLQSAQLLGDACVSFDEHCAVGIEPNYPRIKQQLENSLMLVTALNTHIGYEN
CCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHCCEEEEEEHHHHCCCHH
AAKIAKTAHKNGTTLREEAINLGLVSAEDFDKWVRPEDMVGSLK
HHHHHHHHCCCCCHHHHHHHHCCEECHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]