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The map label for this gene is putP [H]

Identifier: 148826825

GI number: 148826825

Start: 68357

End: 69871

Strand: Reverse

Name: putP [H]

Synonym: CGSHiGG_00405

Alternate gene names: 148826825

Gene position: 69871-68357 (Counterclockwise)

Preceding gene: 148826836

Following gene: 148826824

Centisome position: 3.7

GC content: 39.14

Gene sequence:

>1515_bases
ATGTTTGGATTCGACCCAAGTCTTATTACTTTTACTATTTATATTTTCGGGATGTTGCTGATTGGCGTACTCGCCTATTA
TTACACGAATAATTTATCAGATTACATTCTCGGTGGACGTCGTTTAGGCAGTTTTGTTACTGCAATGTCTGCAGGTGCGT
CAGATATGTCTGGTTGGCTTTTAATGGGCTTACCTGGTGCGGTATATTTATCAGGCTTAGTTGAAGGCTGGATTGCTATT
GGTTTAACTATCGGGGCTTATTTTAACTGGCTTTTAGTGGCTGGTCGTTTGCGTGTTTATACAGAATTAAATAATAATGC
GCTCACTCTCCCAGAATATTTTCACAATCGTTTTGGTTCATCACACAAATTATTAAAACTTGTTTCTGCCACTATTATTT
TAGTGTTTTTTACTATTTATTGTGCTTCTGGTGTAGTGGCTGGCGCAAAATTATTCCAAAATATATTTTCTGTGGAATAT
TCCACCGCACTTTGGTATGGCGCAGCGGCAACCATTGCTTACACGTTCATCGGAGGTTTCCTTGCGGTAAGCTGGACAGA
TACCATTCAAGCCACATTAATGATTTTTGCATTAATTTTAACCCCTGTTTTTGTGTTATTGAGTTTCGCCGATACCGCTC
AATTTTCCGCAGTACTAGAACAAGCTGAGGCTGCCATAAATAAAGATTTTACGGATTTATTTACTTCTACCACACCACTT
GGTTTATTAAGTCTTGCGGCTTGGGGATTAGGCTATTTCGGGCAACCGCATATTTTAGCACGCTTTATGGCTGCGGATTC
TGTCAAATCACTTATCAAAGCACGTCGTATTAGTATGGGTTGGATGGTGCTTTGCTTAGGAGGCGCAATTGGCATTGGCT
TATTCGCTATTCCGTATTTCTTTGCAAATCCAGCTATTGCAGGCACAGTTAATCGCGAACCAGAACAGGTTTTTATTGAA
TTAGCTAAACTTTTATTTAATCCTTGGATCGCGGGCATATTACTTTCAGCTATTTTAGCCGCTGTAATGAGTACATTAAG
TGCTCAATTATTAATTTCTTCAAGCTCAATCACAGAAGATTTCTATAAAGGTTTTATTCGCCCTAACGCATCTGAAAAAG
AGCTCGTATGGCTTGGAAGAATTATGGTGTTAGTTATTGCCGCACTTGCTATCTGGATCGCACAAGATGAAAACAGCAAA
GTATTAAAACTTGTAGAATTTGCTTGGGCGGGGTTTGGTAGTGCATTTGGCCCTGTTGTACTTTTCTCTCTTTTCTGGAA
ACGAATGACATCATCGGGTGCAATGGCGGGTATGCTTGTAGGTGCAGTGACAGTATTTGCTTGGAAAGAAGTTGTTCCAG
CTGATACTGATTGGTTTAAAGTATATGAAATGATCCCAGGCTTTGCTTTCGCCAGCCTTGCAATTATTGTTATTTCATTA
CTTTCCAATAAACCAGAACAAGATATTCTTAATACCTTTGATAAAGCAGAAAAGGCTTATAAGGAAGCAAAATGA

Upstream 100 bases:

>100_bases
TCTTAAATTTCATCAAATATTTAGTCTAAATAGAATAATAGCCCGAAATAAGGTAAAATGCACCCTTTCTAAAATTTTTA
ACCCATTTTGGACTTATAAA

Downstream 100 bases:

>100_bases
TCGACTTTCGCCCTTTTTATCAACAAATTGCTACTACAAATTTATCGGACTGGTTAGAAACCTTACCACTCCAATTGAAA
GAATGGGAAACTCAAACTCA

Product: cytidine deaminase

Products: NA

Alternate protein names: Proline permease [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MFGFDPSLITFTIYIFGMLLIGVLAYYYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWLLMGLPGAVYLSGLVEGWIAI
GLTIGAYFNWLLVAGRLRVYTELNNNALTLPEYFHNRFGSSHKLLKLVSATIILVFFTIYCASGVVAGAKLFQNIFSVEY
STALWYGAAATIAYTFIGGFLAVSWTDTIQATLMIFALILTPVFVLLSFADTAQFSAVLEQAEAAINKDFTDLFTSTTPL
GLLSLAAWGLGYFGQPHILARFMAADSVKSLIKARRISMGWMVLCLGGAIGIGLFAIPYFFANPAIAGTVNREPEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSAQLLISSSSITEDFYKGFIRPNASEKELVWLGRIMVLVIAALAIWIAQDENSK
VLKLVEFAWAGFGSAFGPVVLFSLFWKRMTSSGAMAGMLVGAVTVFAWKEVVPADTDWFKVYEMIPGFAFASLAIIVISL
LSNKPEQDILNTFDKAEKAYKEAK

Sequences:

>Translated_504_residues
MFGFDPSLITFTIYIFGMLLIGVLAYYYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWLLMGLPGAVYLSGLVEGWIAI
GLTIGAYFNWLLVAGRLRVYTELNNNALTLPEYFHNRFGSSHKLLKLVSATIILVFFTIYCASGVVAGAKLFQNIFSVEY
STALWYGAAATIAYTFIGGFLAVSWTDTIQATLMIFALILTPVFVLLSFADTAQFSAVLEQAEAAINKDFTDLFTSTTPL
GLLSLAAWGLGYFGQPHILARFMAADSVKSLIKARRISMGWMVLCLGGAIGIGLFAIPYFFANPAIAGTVNREPEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSAQLLISSSSITEDFYKGFIRPNASEKELVWLGRIMVLVIAALAIWIAQDENSK
VLKLVEFAWAGFGSAFGPVVLFSLFWKRMTSSGAMAGMLVGAVTVFAWKEVVPADTDWFKVYEMIPGFAFASLAIIVISL
LSNKPEQDILNTFDKAEKAYKEAK
>Mature_504_residues
MFGFDPSLITFTIYIFGMLLIGVLAYYYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWLLMGLPGAVYLSGLVEGWIAI
GLTIGAYFNWLLVAGRLRVYTELNNNALTLPEYFHNRFGSSHKLLKLVSATIILVFFTIYCASGVVAGAKLFQNIFSVEY
STALWYGAAATIAYTFIGGFLAVSWTDTIQATLMIFALILTPVFVLLSFADTAQFSAVLEQAEAAINKDFTDLFTSTTPL
GLLSLAAWGLGYFGQPHILARFMAADSVKSLIKARRISMGWMVLCLGGAIGIGLFAIPYFFANPAIAGTVNREPEQVFIE
LAKLLFNPWIAGILLSAILAAVMSTLSAQLLISSSSITEDFYKGFIRPNASEKELVWLGRIMVLVIAALAIWIAQDENSK
VLKLVEFAWAGFGSAFGPVVLFSLFWKRMTSSGAMAGMLVGAVTVFAWKEVVPADTDWFKVYEMIPGFAFASLAIIVISL
LSNKPEQDILNTFDKAEKAYKEAK

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=501, Percent_Identity=45.3093812375249, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI4507031, Length=542, Percent_Identity=26.9372693726937, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI14140236, Length=483, Percent_Identity=23.6024844720497, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI17941285, Length=407, Percent_Identity=25.5528255528256, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1787251, Length=498, Percent_Identity=62.0481927710843, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI87082237, Length=500, Percent_Identity=25.2, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790503, Length=470, Percent_Identity=25.1063829787234, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI115533094, Length=380, Percent_Identity=26.8421052631579, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221459584, Length=362, Percent_Identity=25.6906077348066, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24645928, Length=381, Percent_Identity=26.509186351706, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221459588, Length=434, Percent_Identity=25.5760368663594, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24651739, Length=437, Percent_Identity=23.5697940503432, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221459586, Length=387, Percent_Identity=21.4470284237726, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI221459582, Length=370, Percent_Identity=24.5945945945946, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24651741, Length=429, Percent_Identity=23.5431235431235, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24650192, Length=401, Percent_Identity=23.6907730673317, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281362918, Length=434, Percent_Identity=25.3456221198157, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24640370, Length=361, Percent_Identity=24.0997229916898, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 54933; Mature: 54933

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGFDPSLITFTIYIFGMLLIGVLAYYYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHCCCCCCCCEE
LMGLPGAVYLSGLVEGWIAIGLTIGAYFNWLLVAGRLRVYTELNNNALTLPEYFHNRFGS
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECHHHHHHHCCC
SHKLLKLVSATIILVFFTIYCASGVVAGAKLFQNIFSVEYSTALWYGAAATIAYTFIGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVSWTDTIQATLMIFALILTPVFVLLSFADTAQFSAVLEQAEAAINKDFTDLFTSTTPL
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
GLLSLAAWGLGYFGQPHILARFMAADSVKSLIKARRISMGWMVLCLGGAIGIGLFAIPYF
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FANPAIAGTVNREPEQVFIELAKLLFNPWIAGILLSAILAAVMSTLSAQLLISSSSITED
HCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
FYKGFIRPNASEKELVWLGRIMVLVIAALAIWIAQDENSKVLKLVEFAWAGFGSAFGPVV
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
LFSLFWKRMTSSGAMAGMLVGAVTVFAWKEVVPADTDWFKVYEMIPGFAFASLAIIVISL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
LSNKPEQDILNTFDKAEKAYKEAK
HCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFGFDPSLITFTIYIFGMLLIGVLAYYYTNNLSDYILGGRRLGSFVTAMSAGASDMSGWL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHCCCCCCCCEE
LMGLPGAVYLSGLVEGWIAIGLTIGAYFNWLLVAGRLRVYTELNNNALTLPEYFHNRFGS
EECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEECHHHHHHHCCC
SHKLLKLVSATIILVFFTIYCASGVVAGAKLFQNIFSVEYSTALWYGAAATIAYTFIGGF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAVSWTDTIQATLMIFALILTPVFVLLSFADTAQFSAVLEQAEAAINKDFTDLFTSTTPL
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHH
GLLSLAAWGLGYFGQPHILARFMAADSVKSLIKARRISMGWMVLCLGGAIGIGLFAIPYF
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FANPAIAGTVNREPEQVFIELAKLLFNPWIAGILLSAILAAVMSTLSAQLLISSSSITED
HCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
FYKGFIRPNASEKELVWLGRIMVLVIAALAIWIAQDENSKVLKLVEFAWAGFGSAFGPVV
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHH
LFSLFWKRMTSSGAMAGMLVGAVTVFAWKEVVPADTDWFKVYEMIPGFAFASLAIIVISL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
LSNKPEQDILNTFDKAEKAYKEAK
HCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]