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The map label for this gene is licA [H]

Identifier: 148826806

GI number: 148826806

Start: 43613

End: 44716

Strand: Reverse

Name: licA [H]

Synonym: CGSHiGG_00280

Alternate gene names: 148826806

Gene position: 44716-43613 (Counterclockwise)

Preceding gene: 148826807

Following gene: 148826805

Centisome position: 2.37

GC content: 31.79

Gene sequence:

>1104_bases
ATGCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATC
AATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATC
AATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAATCAAATTGTAGGATTTGTTAAAACTTGCTACAAG
CCTGAGGAAGTATTTCATTTTCTTCATCAGAATTCCATTCCTTTTTCCTCCATTGGAGGAATGACCAATCAAAATGTTCT
ACTTAATATTTCTGGAATTAAGTTTGTATTACGGATCCCTAATGCCGTAAATTTATCACTTATAAATCGAGAATATGAGG
CATTCAATAATGCTCAGGCATATCGTGCTGGCTTGAATGTAGAAACTCCCGTATTAGATGCCAAAAGTGGCGTAAAACTA
ACTCGCTATTTAGAAAATAGTAAGCCGTTAAGTCAGATACAATTAAACGAACAAAGTTGTTTGTCTCAAGTTGTGAATAA
TTTATATCGTTTACACAATAGTGAATTTGTTTTTCGTAATGTATTTAGCGTATTCGATGAGTTTCGCCAATATTTTTCAT
TGCTAGAAAACAAATCCGCTTTTTATCAAGCTGATTCGAAAATGGATAAACTTTCAGCTGTATTTTGGCAATTTGAAGAA
ATCAATAAAGAGATAATTTTACGTCCGTGCCACAATGATTTAGTCCCTGAAAATATGTTATTACAAGATGATCGGCTATT
TTTTATTGATTGGGAATATTCGGGCTTAAATGATCCGCTATTTGATATAGCTACTATCATTGAGGAAGCTCATTTATCGA
AAGAAGCTGCTGATTTTCTATTAGAAACCTATTGCAATCAGACAAATAAATATCACAAGACAGAATTTCAAATCGCTCAC
AAACGGTTAAAAATCCATCGTTTTTGCCAAAATGTATTGTGGTTTTTATGGACAAAAGTAAAAGAAGAACACGGCGAGAA
TTTTGGCGATTATGCGTTAAAACGCTTAGACGCAGCATTTAAACTGTTAGAGGAATTGCCATAA

Upstream 100 bases:

>100_bases
AAAAGTTGAATAAATTCATAAGATTCAGAGCCTTACAAAAATAACTTTAACGTATTAAAATCAAACAAAATTTAAATATA
AAAATGAATACAAAAATGCT

Downstream 100 bases:

>100_bases
TGCGTGGCTATCTCTTTGGCATACTGTCCGCTGTATTTTGGGCATTATCTGGACTGTTGTATAATGAATTGCCATTAAGT
GAATATACCGCGTTAGGGAA

Product: phospho-2-dehydro-3-heoxyheptonate aldolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYK
PEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKL
TRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEE
INKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAH
KRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFKLLEELP

Sequences:

>Translated_367_residues
MQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYK
PEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKL
TRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEE
INKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAH
KRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFKLLEELP
>Mature_367_residues
MQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQIVGFVKTCYK
PEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKL
TRYLENSKPLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEE
INKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAH
KRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAFKLLEELP

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 42550; Mature: 42550

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCCEEEEECCEEEEEECC
NAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSC
CCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHCCHHHH
LSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
INKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFL
HCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAF
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KLLEELP
HHHHHCC
>Mature Secondary Structure
MQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSINQSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NQSINQSINQIVGFVKTCYKPEEVFHFLHQNSIPFSSIGGMTNQNVLLNISGIKFVLRIP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHCCCCCCCEEEEECCEEEEEECC
NAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSKPLSQIQLNEQSC
CCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHCCHHHH
LSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSKMDKLSAVFWQFEE
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
INKEIILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFL
HCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
LETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVKEEHGENFGDYALKRLDAAF
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
KLLEELP
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]