BacMap

Definition	Haemophilus influenzae PittEE chromosome, complete genome.
Accession	NC_009566
Length	1,813,033

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The map label for this gene is fhuC [H]

Identifier: 148826681

GI number: 148826681

Start: 1736679

End: 1737350

Strand: Direct

Name: fhuC [H]

Synonym: CGSHiEE_08770

Alternate gene names: 148826681

Gene position: 1736679-1737350 (Clockwise)

Preceding gene: 148826680

Following gene: 148826682

Centisome position: 95.79

GC content: 55.21

Gene sequence:

>672_bases
TTGATCGGGCATAACGGTTCCGGCAAATCCACCTTAATCAAATTAATGGCACGCCAGACCCAACTGTCCGGCGGTTCGAT
TTCGTTGGACGGCAAAGATATTGCGCACTGGAACCAACGAGAATTTGCCAAACGGGTCGCCTATCTGCCGCAACATCTGC
CCGCTGCCACCAATTTAACCGCATGCGAATTAATCGGCATGGGACGTTATGCGTGGAACGGGCTGTTCGGACGCCAAACG
GCGGCGGATAAACAGGCGATCGCCGAAGCGTTGCGCCTGACCCACACGGAAAAATTCGCCGATCAACTGGTGGATACGCT
GTCCGGCGGCGAACGCTCGCGCATTTGGCTCGCCATGCTATTGGCGCAGCAAAGCCGTTTTCTGCTGTTGGACGAACCGC
TCGCCGCATTGGATATTGCGCACCAAGTGGAAGTTATGCAGTTAGTGCATCAATTAAGTCGCGATTTGGGGCTAGGCGTG
GTGATCGTGATTCACGACATCAATCTGGCGGCGCATTTTTGCGATCATTTGGTGGCGCTGCACAGCGGCAAACTGCTGGC
GCAGGGCGACGCACAGCAAATCGTCAACCCGCCGTTGTTGGAGGCGATTTACGGCATTCGGCTGAACGTGATCCCGCACC
CACAAACCCAACGTCCGGTGAGTTTTTATTAA

Upstream 100 bases:

>100_bases
TGAAACCGTGTTCCGACTTGATCAGATTTCTTTTCGCATTCCGCAGCGTACCTTGCTCTTCCCCACTTCATTCACGTTTG
ATGCCGGCAAGGTGTACGGT

Downstream 100 bases:

>100_bases
AATGCGTAAATTATTAAAAACACTGCTCGGAATGACCGCACTTTTAGCACACAGCGTGCTATTTGCCGCGTCGCATAACG
GCTACACCACGGTGGATTGG

Product: ferrichrome ABC transporter ATP-binding protein

Products: NA

Alternate protein names: Ferric hydroxamate uptake protein C; Ferrichrome transport ATP-binding protein FhuC; Iron(III)-hydroxamate import ATP-binding protein FhuC [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MIGHNGSGKSTLIKLMARQTQLSGGSISLDGKDIAHWNQREFAKRVAYLPQHLPAATNLTACELIGMGRYAWNGLFGRQT
AADKQAIAEALRLTHTEKFADQLVDTLSGGERSRIWLAMLLAQQSRFLLLDEPLAALDIAHQVEVMQLVHQLSRDLGLGV
VIVIHDINLAAHFCDHLVALHSGKLLAQGDAQQIVNPPLLEAIYGIRLNVIPHPQTQRPVSFY

Sequences:

>Translated_223_residues
MIGHNGSGKSTLIKLMARQTQLSGGSISLDGKDIAHWNQREFAKRVAYLPQHLPAATNLTACELIGMGRYAWNGLFGRQT
AADKQAIAEALRLTHTEKFADQLVDTLSGGERSRIWLAMLLAQQSRFLLLDEPLAALDIAHQVEVMQLVHQLSRDLGLGV
VIVIHDINLAAHFCDHLVALHSGKLLAQGDAQQIVNPPLLEAIYGIRLNVIPHPQTQRPVSFY
>Mature_223_residues
MIGHNGSGKSTLIKLMARQTQLSGGSISLDGKDIAHWNQREFAKRVAYLPQHLPAATNLTACELIGMGRYAWNGLFGRQT
AADKQAIAEALRLTHTEKFADQLVDTLSGGERSRIWLAMLLAQQSRFLLLDEPLAALDIAHQVEVMQLVHQLSRDLGLGV
VIVIHDINLAAHFCDHLVALHSGKLLAQGDAQQIVNPPLLEAIYGIRLNVIPHPQTQRPVSFY

Specific function: Part of the ABC transporter complex FhuCDB involved in iron(3+)-hydroxamate import. Responsible for energy coupling to the transport system [H]

COG id: COG1120

COG function: function code PH; ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=237, Percent_Identity=26.5822784810127, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI9961252, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI9961250, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI4505771, Length=208, Percent_Identity=28.3653846153846, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI6005701, Length=197, Percent_Identity=27.9187817258883, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI9665248, Length=200, Percent_Identity=29, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI42741659, Length=200, Percent_Identity=29, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI148612844, Length=203, Percent_Identity=30.0492610837438, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI255708477, Length=203, Percent_Identity=30.0492610837438, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI27477115, Length=197, Percent_Identity=27.4111675126904, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI47078218, Length=196, Percent_Identity=24.4897959183673, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1786345, Length=222, Percent_Identity=53.6036036036036, Blast_Score=253, Evalue=9e-69,
Organism=Escherichia coli, GI1786803, Length=220, Percent_Identity=41.3636363636364, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI1790739, Length=222, Percent_Identity=37.8378378378378, Blast_Score=163, Evalue=8e-42,
Organism=Escherichia coli, GI1790544, Length=214, Percent_Identity=29.9065420560748, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI48994883, Length=227, Percent_Identity=25.1101321585903, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788761, Length=191, Percent_Identity=30.3664921465969, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787370, Length=200, Percent_Identity=30, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1787758, Length=200, Percent_Identity=29.5, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1786398, Length=203, Percent_Identity=28.0788177339901, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081709, Length=198, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789032, Length=204, Percent_Identity=29.9019607843137, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI87081791, Length=208, Percent_Identity=31.7307692307692, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI145693107, Length=216, Percent_Identity=25, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787029, Length=201, Percent_Identity=28.8557213930348, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788450, Length=205, Percent_Identity=29.7560975609756, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1787712, Length=188, Percent_Identity=33.5106382978723, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789962, Length=206, Percent_Identity=26.2135922330097, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788165, Length=207, Percent_Identity=28.0193236714976, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788002, Length=238, Percent_Identity=30.2521008403361, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789593, Length=205, Percent_Identity=28.2926829268293, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787759, Length=213, Percent_Identity=25.3521126760563, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI87081782, Length=196, Percent_Identity=29.0816326530612, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787500, Length=204, Percent_Identity=24.0196078431373, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1786253, Length=197, Percent_Identity=29.9492385786802, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI48994943, Length=219, Percent_Identity=26.9406392694064, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787105, Length=214, Percent_Identity=29.9065420560748, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790190, Length=216, Percent_Identity=25.462962962963, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789891, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1789890, Length=205, Percent_Identity=25.8536585365854, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1788644, Length=203, Percent_Identity=28.0788177339901, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1789963, Length=213, Percent_Identity=24.4131455399061, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787089, Length=211, Percent_Identity=25.5924170616114, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790467, Length=221, Percent_Identity=26.2443438914027, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1786703, Length=189, Percent_Identity=30.1587301587302, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87081834, Length=193, Percent_Identity=27.979274611399, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789864, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788506, Length=211, Percent_Identity=24.1706161137441, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790162, Length=211, Percent_Identity=28.9099526066351, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1786698, Length=193, Percent_Identity=27.979274611399, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786872, Length=199, Percent_Identity=25.1256281407035, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082268, Length=196, Percent_Identity=27.5510204081633, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787143, Length=200, Percent_Identity=25, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789873, Length=194, Percent_Identity=31.4432989690722, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788472, Length=190, Percent_Identity=24.7368421052632, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788225, Length=206, Percent_Identity=25.2427184466019, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI48994997, Length=210, Percent_Identity=25.2380952380952, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1789672, Length=208, Percent_Identity=26.4423076923077, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786563, Length=188, Percent_Identity=30.8510638297872, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789991, Length=189, Percent_Identity=25.9259259259259, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788897, Length=194, Percent_Identity=28.8659793814433, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17510237, Length=191, Percent_Identity=29.3193717277487, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI212646699, Length=228, Percent_Identity=27.1929824561404, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17541710, Length=201, Percent_Identity=27.8606965174129, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71992285, Length=205, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25146777, Length=207, Percent_Identity=26.5700483091787, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193209708, Length=207, Percent_Identity=28.0193236714976, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983523, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565586, Length=194, Percent_Identity=24.2268041237113, Blast_Score=67, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115535101, Length=207, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193202349, Length=207, Percent_Identity=25.1207729468599, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17567269, Length=206, Percent_Identity=23.7864077669903, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323959, Length=208, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322640, Length=205, Percent_Identity=26.3414634146341, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324498, Length=210, Percent_Identity=26.1904761904762, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324985, Length=229, Percent_Identity=21.3973799126638, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28573571, Length=196, Percent_Identity=28.0612244897959, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28573573, Length=196, Percent_Identity=28.0612244897959, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136662, Length=200, Percent_Identity=29.5, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076682, Length=209, Percent_Identity=29.6650717703349, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI161076684, Length=209, Percent_Identity=29.6650717703349, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581617, Length=209, Percent_Identity=29.6650717703349, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24581615, Length=209, Percent_Identity=29.6650717703349, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582014, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24582012, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653245, Length=207, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281363262, Length=206, Percent_Identity=29.126213592233, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.34 [H]

Molecular weight: Translated: 24544; Mature: 24544

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGHNGSGKSTLIKLMARQTQLSGGSISLDGKDIAHWNQREFAKRVAYLPQHLPAATNLT
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCCCCH
ACELIGMGRYAWNGLFGRQTAADKQAIAEALRLTHTEKFADQLVDTLSGGERSRIWLAML
HHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LAQQSRFLLLDEPLAALDIAHQVEVMQLVHQLSRDLGLGVVIVIHDINLAAHFCDHLVAL
HHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
HSGKLLAQGDAQQIVNPPLLEAIYGIRLNVIPHPQTQRPVSFY
HCCCEEECCCHHHHCCCHHHHHHHHCEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MIGHNGSGKSTLIKLMARQTQLSGGSISLDGKDIAHWNQREFAKRVAYLPQHLPAATNLT
CCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCCCCH
ACELIGMGRYAWNGLFGRQTAADKQAIAEALRLTHTEKFADQLVDTLSGGERSRIWLAML
HHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LAQQSRFLLLDEPLAALDIAHQVEVMQLVHQLSRDLGLGVVIVIHDINLAAHFCDHLVAL
HHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHH
HSGKLLAQGDAQQIVNPPLLEAIYGIRLNVIPHPQTQRPVSFY
HCCCEEECCCHHHHCCCHHHHHHHHCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 3301821; 2823072; 8202364; 9278503 [H]