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The map label for this gene is pepP [H]

Identifier: 148826539

GI number: 148826539

Start: 1581441

End: 1582721

Strand: Direct

Name: pepP [H]

Synonym: CGSHiEE_07980

Alternate gene names: 148826539

Gene position: 1581441-1582721 (Clockwise)

Preceding gene: 148826538

Following gene: 148826540

Centisome position: 87.23

GC content: 39.19

Gene sequence:

>1281_bases
ATGGAATTGACTTATATGGCTAAATTGCCTAAAGAAGAATTTGAGGAACGTCGCACACGAGTATTCGCTCAAATGCAACC
TAATTCAGCATTATTGCTTTTTTCTGAAATCGAAAAACGCCGTAATAATGATTGTACCTATCCTTTCCGTCAAGATAGCT
ATTTTTGGTATTTAACAGGCTTTAATGAACCGAATGCAGCACTGTTATTACTGAAAACAGAACAAGTAGAAAAAGCCATT
ATTTTTCTTCGTCCATGCGATCCGTTACTTGAAACGTGGAATGGTCGCCGATTAGGTGTTGAGCGTGCACCACAGCAACT
TAATGTAAATGAAGCCTATTCTATTGAAGAATTCGCTACCGTACTGCCAAAAATACTGAAAAATTTGACCGCACTTTACC
ATGTGCCAGAAATTCATACTTGGGGTGATACATTGGTGTCAGAAAGTGCGGTGAATTTTAGCGAGATTTTAGATTGGCGA
CCAATGCTCAGCGAAATGCGCCTTATAAAATCGCCGAATGAAATCCGCTTAATACAACAAGCGGGACAAATTACGGCACT
TGGGCATATTAAAGCGATGCAAACAACACGCCCAAATCGCTTTGAATATGAAATTGAAAGCGATATTTTGCATGAATTTA
ATCGCCATTGCGCAAGATTTCCTTCTTACAATTCCATTGTTGCAGGAGGAAATAACGCCTGTATTTTGCACTACACAGAA
AATGATCGCCCATTAAATGATGGGGATTTAGTACTGATTGACGCTGGCTGTGAATTTGCTATGTATGCAGGCGATATTAC
CCGCACTTTTCCTGTAAATGGAAAATTTAGCCAGCCTCAACGTGAAATTTACGAGTTAGTTTTAAAAGCACAAAAACGTG
CGATTGAGTTACTTATACCGGGCAATTCCATTAAGCAAGCCAATGATGAAGTTATTCGTATTAAAACCCAAGGATTAGTG
GATTTAGGCATCTTGAAAGGAGATGTGGATACACTTATTGAACAACAAGCTTATCTCCAATTTTATATGCACGGATTAGG
TCACTGGCTAGGGCTAGATGTGCATGATGTAGGTAGTTATGGACAAGATAAGCAACGGATACTCGAAATCGGCATGGTGA
TTACCGTTGAGCCTGGTATTTATATTTCAGAAGATGCTGATGTGCCAGAGCAATACAAAGGCATTGGTGTGCGCATTGAG
GACAATTTACTGATGACTGAATATGGTAATAAAATCCTAACTGCAGCGGCCCTAAAGAAATTGCAGATATTGAAAATTTA
A

Upstream 100 bases:

>100_bases
AAATCATTGAATATGTTCGCACCATTGCAATGTTATTCTATTCTCATTTCAACGAAGGAGAAATTGAGAGCAAACCTGTA
TTACATTAAGGAGATCTAGG

Downstream 100 bases:

>100_bases
TGTAATTTTTAATAAAAATTTTTAAATTGTGATCTAGTGCACAGTTTTTTATTGCTCAAAATGTTAGCATTAGAACCAGT
TAAAAACCGAACCAATCAGT

Product: Xaa-Pro aminopeptidase

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MELTYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTGFNEPNAALLLLKTEQVEKAI
IFLRPCDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWR
PMLSEMRLIKSPNEIRLIQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGNNACILHYTE
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLIPGNSIKQANDEVIRIKTQGLV
DLGILKGDVDTLIEQQAYLQFYMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIE
DNLLMTEYGNKILTAAALKKLQILKI

Sequences:

>Translated_426_residues
MELTYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTGFNEPNAALLLLKTEQVEKAI
IFLRPCDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWR
PMLSEMRLIKSPNEIRLIQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGNNACILHYTE
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLIPGNSIKQANDEVIRIKTQGLV
DLGILKGDVDTLIEQQAYLQFYMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIE
DNLLMTEYGNKILTAAALKKLQILKI
>Mature_426_residues
MELTYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTGFNEPNAALLLLKTEQVEKAI
IFLRPCDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFATVLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWR
PMLSEMRLIKSPNEIRLIQQAGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGNNACILHYTE
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLIPGNSIKQANDEVIRIKTQGLV
DLGILKGDVDTLIEQQAYLQFYMHGLGHWLGLDVHDVGSYGQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIE
DNLLMTEYGNKILTAAALKKLQILKI

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=433, Percent_Identity=35.3348729792148, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI149589008, Length=459, Percent_Identity=28.9760348583878, Blast_Score=193, Evalue=3e-49,
Organism=Homo sapiens, GI260593665, Length=290, Percent_Identity=33.7931034482759, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI260593663, Length=453, Percent_Identity=27.3730684326711, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1789275, Length=427, Percent_Identity=52.9274004683841, Blast_Score=479, Evalue=1e-136,
Organism=Escherichia coli, GI1788728, Length=254, Percent_Identity=29.5275590551181, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790282, Length=434, Percent_Identity=25.1152073732719, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508215, Length=457, Percent_Identity=31.2910284463895, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71989583, Length=257, Percent_Identity=31.1284046692607, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=434, Percent_Identity=31.5668202764977, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6321118, Length=426, Percent_Identity=30.2816901408451, Blast_Score=175, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19920384, Length=413, Percent_Identity=35.3510895883777, Blast_Score=221, Evalue=6e-58,
Organism=Drosophila melanogaster, GI21357079, Length=418, Percent_Identity=34.4497607655502, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48754; Mature: 48754

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELTYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTG
CCEEEHHCCCHHHHHHHHHHEEEEECCCCEEEEHHHHHHHCCCCCCCCEECCCEEEEEEE
FNEPNAALLLLKTEQVEKAIIFLRPCDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFAT
CCCCCCEEEEEEECCCCEEEEEEECCCHHHHCCCCCEECHHCCCCCCCCCCCCCHHHHHH
VLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWRPMLSEMRLIKSPNEIRLIQQ
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHH
AGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGNNACILHYTE
CCCEEEEEEEEEHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECC
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLIP
CCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEC
GNSIKQANDEVIRIKTQGLVDLGILKGDVDTLIEQQAYLQFYMHGLGHWLGLDVHDVGSY
CCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
GQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIEDNLLMTEYGNKILTAAALKK
CCHHHHHHHCCEEEEECCCEEEECCCCCCHHHCCCEEEEECCEEEECCCCCHHHHHHHHH
LQILKI
HHEECC
>Mature Secondary Structure
MELTYMAKLPKEEFEERRTRVFAQMQPNSALLLFSEIEKRRNNDCTYPFRQDSYFWYLTG
CCEEEHHCCCHHHHHHHHHHEEEEECCCCEEEEHHHHHHHCCCCCCCCEECCCEEEEEEE
FNEPNAALLLLKTEQVEKAIIFLRPCDPLLETWNGRRLGVERAPQQLNVNEAYSIEEFAT
CCCCCCEEEEEEECCCCEEEEEEECCCHHHHCCCCCEECHHCCCCCCCCCCCCCHHHHHH
VLPKILKNLTALYHVPEIHTWGDTLVSESAVNFSEILDWRPMLSEMRLIKSPNEIRLIQQ
HHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEHHHH
AGQITALGHIKAMQTTRPNRFEYEIESDILHEFNRHCARFPSYNSIVAGGNNACILHYTE
CCCEEEEEEEEEHHCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECC
NDRPLNDGDLVLIDAGCEFAMYAGDITRTFPVNGKFSQPQREIYELVLKAQKRAIELLIP
CCCCCCCCCEEEEECCCCEEEEECCCEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEC
GNSIKQANDEVIRIKTQGLVDLGILKGDVDTLIEQQAYLQFYMHGLGHWLGLDVHDVGSY
CCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCC
GQDKQRILEIGMVITVEPGIYISEDADVPEQYKGIGVRIEDNLLMTEYGNKILTAAALKK
CCHHHHHHHCCEEEEECCCEEEECCCCCCHHHCCCEEEEECCEEEECCCCCHHHHHHHHH
LQILKI
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]