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The map label for this gene is frdA [H]

Identifier: 148826520

GI number: 148826520

Start: 1563902

End: 1565701

Strand: Direct

Name: frdA [H]

Synonym: CGSHiEE_07885

Alternate gene names: 148826520

Gene position: 1563902-1565701 (Clockwise)

Preceding gene: 148826518

Following gene: 148826521

Centisome position: 86.26

GC content: 42.06

Gene sequence:

>1800_bases
GTGCAAACAGTTAATGTCGATATTGCGATTGTTGGTGCTGGTGGCGGTGGTTTACGTGCAGCGATTGCCGCAGCAGAAGC
AAATCCTAACTTAAAAATTGCATTAGTTTCTAAAGTATACCCGATGCGTAGCCATACTGTAGCAGCAGAAGGTGGCGCAG
CGGCAGTTATCAAAGAAGAAGATTCTTACGATAAACACTTCCAAGATACCGTTGCTGGTGGGGACTGGCTTTGTGAGCAG
GATGTAGTGGAATATTTCGTGCAACATTCCCCTGTAGAAATGACTCAATTAGAACGTTGGGGATGTCCTTGGAGCCGTAA
AGCTGATGGCGATGTAAACGTACGTCGTTTTGGTGGAATGAAAATTGAGCGCACTTGGTTCGCAGCGGATAAAACAGGTT
TCCACTTATTACACACACTTTTCCAAACTTCTATTCAATATCCACAAATTCAACGTTTTGATGAACATTTCGTATTAGAT
ATTCTTGTTGATGATGGCCATGCTCGTGGTATGGTTGCAATGAATATGATGGAAGGTTCGCTTGTTCAAATTAATGCCAA
TGCGGTTGTTATTGCAACTGGTGGCGGTTGTCGTGCATTTAAATTTAATACCAATGGCGGCATTGTAACAGGTGACGGCT
TATCTATGGCATATCGTCACGGTGTACCACTTCGTGATATGGAGTTTGTTCAATATCATCCAACAGGCTTACCTAATACG
GGTATTTTAATGACTGAAGGTTGTCGTGGCGAAGGCGGTATCTTGGTTAATAAAGATGGCTATCGCTATCTTCAAGATTA
CGGTCTAGGTCCTGAAACGCCAATTGGCAAACCGCAAAATAAATATATGGAACTTGGCCCTCGTGATAAGGTTTCTCAAG
CATTCTGGCAAGAATGGAAAAAAGGTAATACCTTAAAAACCGCGAAAGGCGTAGATGTGGTGCATTTAGATTTACGTCAT
CTTGGTGAAAAATATTTACATGAGCGTCTGCCATTCATTTGTGAATTAGCAAGTGCTTATGAAGGTGTAAATCCAGTAAA
TGAACCAATTCCAGTTCGTCCAGTTGTTCACTACACCATGGGCGGTATTGAGGTTGATTTTAACAGCGAAACTCGTATCA
AAGGTTTATTTGCTGTAGGAGAATGCGCATCTTCAGGTTTACATGGTGCAAACCGTTTAGGATCTAACTCTTTAGCTGAA
CTTGTTGTGTTAGGTCGCGTTGCTGGGGAATATGCAGCACAACGTGCCGTTGAAGCTCAATCTGTAAATCAAAGTGCGGT
TGATGCTCAAGCAAAAGACGTTGTTGCTCGCCTAGAAGCTCTTCACAAACAAGAAGGTAATGAATCTTGGTCTGAAATCC
GTGATGAAATGGGTACCGTGATGGAAGAAGGTTGTGGTATTTACCGTGACCAAGCAAGTATGCAAAAAGCAGTAGATAAA
ATTGCAGAGTTAAAAGAACGTTACAAACGTATTCGCGTATCAGATAATTCAAGCGTGTTCAATACAGATGTGCTTTACAC
CGTTGAGTTGGGTTACATTCTAGATGTTGCGCAATCTATTGCAAATTCAGCAATTGAACGTAAAGAATCTCGTGGTGCTC
ACCAACGCTTAGATTACACAGAACGTGACGATGTAAATTATTTAAAACACACACTTGCTTTCTACAATGAGAATGGTGCG
CCGCACATTGAATACAGTCCGGTGAAAATTACTAAATCTCAACCTGCAAAACGTGTTTACGGTGCGGAAGCAGAAGCTCA
AGAAGCAGCTGCGAAAGCTAAGGAGCAAGCAAATGGCTAA

Upstream 100 bases:

>100_bases
TAAAAAACGTTATTAATTTGTAACAAAAAATGGCACAATGCCCACACAATATTACCCTTTTAGGGGATTTATTTTTACTT
TCTATTGATTGGAGGATATC

Downstream 100 bases:

>100_bases
TTCTCCAGTAATGAATGTTGAAGTATTACGCTACAATCCTGAAATCGATCAAGAGCCACATTTAAGCACCTATCAAGTAC
CTTATGATAATCAAACTTCA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLD
ILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAQSVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNENGA
PHIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG

Sequences:

>Translated_599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLD
ILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAQSVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNENGA
PHIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG
>Mature_599_residues
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEEDSYDKHFQDTVAGGDWLCEQ
DVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGMKIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLD
ILVDDGHARGMVAMNMMEGSLVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWKKGNTLKTAKGVDVVHLDLRH
LGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTMGGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAE
LVVLGRVAGEYAAQRAVEAQSVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYTERDDVNYLKHTLAFYNENGA
PHIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=575, Percent_Identity=37.9130434782609, Blast_Score=365, Evalue=1e-101,
Organism=Escherichia coli, GI1790597, Length=603, Percent_Identity=74.9585406301824, Blast_Score=907, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=542, Percent_Identity=39.6678966789668, Blast_Score=348, Evalue=7e-97,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=31.5508021390374, Blast_Score=252, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17505833, Length=535, Percent_Identity=38.3177570093458, Blast_Score=345, Evalue=4e-95,
Organism=Caenorhabditis elegans, GI17550100, Length=540, Percent_Identity=36.8518518518519, Blast_Score=340, Evalue=9e-94,
Organism=Caenorhabditis elegans, GI71986328, Length=436, Percent_Identity=27.5229357798165, Blast_Score=120, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322701, Length=556, Percent_Identity=38.8489208633094, Blast_Score=384, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6322416, Length=564, Percent_Identity=38.4751773049645, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6320788, Length=492, Percent_Identity=25.609756097561, Blast_Score=101, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17137288, Length=598, Percent_Identity=38.1270903010033, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24655642, Length=598, Percent_Identity=38.1270903010033, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24655647, Length=598, Percent_Identity=38.1270903010033, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24663005, Length=600, Percent_Identity=34.1666666666667, Blast_Score=336, Evalue=3e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005884
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65901; Mature: 65901

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEE
CCEEEEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCCCEEEECCCEEEEEECC
DSYDKHFQDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGM
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLDILVDDGHARGMVAMNMMEGS
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEEECCCCCCEEEEEECCCC
LVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
EEEEECCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHCCCCCCCCHHEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWK
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTM
CCCCEEECCCCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAELVVLGRVAGEYAAQRAVEAQ
CCEEEECCCCCCEEEEEEEHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
HCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYT
HHHHHHHHHHEEECCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTLAFYNENGAPHIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG
CCCCHHHHHHHHHHHCCCCCCCEEECCEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQTVNVDIAIVGAGGGGLRAAIAAAEANPNLKIALVSKVYPMRSHTVAAEGGAAAVIKEE
CCEEEEEEEEEECCCCCHHHEEEEECCCCCEEEEEEECCCCCCCCEEEECCCEEEEEECC
DSYDKHFQDTVAGGDWLCEQDVVEYFVQHSPVEMTQLERWGCPWSRKADGDVNVRRFGGM
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCE
KIERTWFAADKTGFHLLHTLFQTSIQYPQIQRFDEHFVLDILVDDGHARGMVAMNMMEGS
EEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHCCCEEEEEEEEECCCCCCEEEEEECCCC
LVQINANAVVIATGGGCRAFKFNTNGGIVTGDGLSMAYRHGVPLRDMEFVQYHPTGLPNT
EEEEECCEEEEEECCCEEEEEEECCCCEEECCCCHHHHHCCCCCCCCHHEEECCCCCCCC
GILMTEGCRGEGGILVNKDGYRYLQDYGLGPETPIGKPQNKYMELGPRDKVSQAFWQEWK
CEEEECCCCCCCCEEECCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHH
KGNTLKTAKGVDVVHLDLRHLGEKYLHERLPFICELASAYEGVNPVNEPIPVRPVVHYTM
CCCCEEECCCCEEEEHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEE
GGIEVDFNSETRIKGLFAVGECASSGLHGANRLGSNSLAELVVLGRVAGEYAAQRAVEAQ
CCEEEECCCCCCEEEEEEEHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVNQSAVDAQAKDVVARLEALHKQEGNESWSEIRDEMGTVMEEGCGIYRDQASMQKAVDK
HCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
IAELKERYKRIRVSDNSSVFNTDVLYTVELGYILDVAQSIANSAIERKESRGAHQRLDYT
HHHHHHHHHHEEECCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCC
ERDDVNYLKHTLAFYNENGAPHIEYSPVKITKSQPAKRVYGAEAEAQEAAAKAKEQANG
CCCCHHHHHHHHHHHCCCCCCCEEECCEEEECCCCHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]