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The map label for this gene is tyrA [H]

Identifier: 148825874

GI number: 148825874

Start: 869118

End: 870242

Strand: Direct

Name: tyrA [H]

Synonym: CGSHiEE_04195

Alternate gene names: 148825874

Gene position: 869118-870242 (Clockwise)

Preceding gene: 148825873

Following gene: 148825880

Centisome position: 47.94

GC content: 38.93

Gene sequence:

>1125_bases
ATGGAAGCCCTTAAAGATTTACGTTCTGAAATTGATTCGCTTGATCGCGAACTTATCCAACTTTTTGCTAAACGTCTTGA
GTTGGTTTCTCAAGTCGGTAAAGTTAAACACCAACATGGATTACCTATTTATGCGCCAGAACGTGAAATAGCAATGCTCC
AAGCACGTCGTTTAGAAGCTGAAAAAGCAGGCATTTCAGCCGATTTGATTGAAGATGTTCTACGCCGTTTTATGCGTGAA
TCCTATGCCAATGAAAACCAATTTGGTTTTAAAACTATCAATTCTGATATTCACAAAATTGTTATTGTGGGTGGCTATGG
TAAATTAGGTGGTTTATTTGCCCGTTATTTACGTGCATCTGGCTATCCAATTTCTATTTTAGATCGCGAAGATTGGGCGG
TGGCTGAAAGTATTTTAGCGAATGCTGATGTCGTGATCGTTTCCGTCCCCATCAATATTACTTTGGAAACGATTGAGCGA
CTAAAACCTTATTTAACAGAAAATATGTTGCTTGCAGATTTAACTTCTGTTAAGCGTGAACCGCTAGCGAAAATGCTTGA
AGTTCATTCTGGTGCAGTTTTAGGTTTACATCCAATGTTTGGTGCAGATATTGCAAGTATGGCAAAACAAGTGGTTGTAC
GTTGTGATGGACGTTTTCCTGAACGTTATGAATGGTTACTTGAGCAAATTCAAATTTGGGGCGCAAAAATTTATCAAACC
AATGCCACAGAACACGATCACAATATGACTTATATACAAGCCTTGCGCCATTTTTCGACTTTTGCGAATGGTTTACACCT
TTCCAAACAGCCCGTTAATCTTGCTAATTTATTGGCGCTTTCTTCTCCTATTTATCGCTTAGAACTTGCGATGATCGGTC
GCTTATTTGCGCAAGATGCAGAGCTTTACGCAGATATTATTATGGATAAGCCAGAAAATTTAGCGGTAATTGAAACGCTA
AAACAAACTTACGACGAAGCCTTAACTTTCTTTGAAAAGAATGATCGTCAAGGTTTTATTGATGCTTTCCACAAGGTGCG
TGACTGGTTCGGCGATTATTCCGAACAATTCTTAAAAGAAAGCCGTCAGCTATTGCAACAGGCAAATGATTTGAAACAAG
GGTAG

Upstream 100 bases:

>100_bases
CAATCCGCATAACTTCATTGCCTTTCCTGTAAAATTCTAGTAATCTCCTTGTAATTAATTTTTTACAATATATGTAAGAT
AAACATTACAGGTGAGTTTT

Downstream 100 bases:

>100_bases
AGAAAAGTGCGGTGAAATTTCACCGCAGTTTTTTACTGTCTCGCCAATCTTAAATTTTCAGGTAAATTCTCAAAATTAGA
GCGGAATGGATTAATGTCTA

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEAEKAGISADLIEDVLRRFMRE
SYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINITLETIER
LKPYLTENMLLADLTSVKREPLAKMLEVHSGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQT
NATEHDHNMTYIQALRHFSTFANGLHLSKQPVNLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKPENLAVIETL
KQTYDEALTFFEKNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQANDLKQG

Sequences:

>Translated_374_residues
MEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEAEKAGISADLIEDVLRRFMRE
SYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINITLETIER
LKPYLTENMLLADLTSVKREPLAKMLEVHSGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQT
NATEHDHNMTYIQALRHFSTFANGLHLSKQPVNLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKPENLAVIETL
KQTYDEALTFFEKNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQANDLKQG
>Mature_374_residues
MEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEAEKAGISADLIEDVLRRFMRE
SYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRASGYPISILDREDWAVAESILANADVVIVSVPINITLETIER
LKPYLTENMLLADLTSVKREPLAKMLEVHSGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQT
NATEHDHNMTYIQALRHFSTFANGLHLSKQPVNLANLLALSSPIYRLELAMIGRLFAQDAELYADIIMDKPENLAVIETL
KQTYDEALTFFEKNDRQGFIDAFHKVRDWFGDYSEQFLKESRQLLQQANDLKQG

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=370, Percent_Identity=58.3783783783784, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42654; Mature: 42654

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EKAGISADLIEDVLRRFMRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRAS
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHCC
GYPISILDREDWAVAESILANADVVIVSVPINITLETIERLKPYLTENMLLADLTSVKRE
CCCEEEECCCHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
PLAKMLEVHSGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQT
HHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEC
NATEHDHNMTYIQALRHFSTFANGLHLSKQPVNLANLLALSSPIYRLELAMIGRLFAQDA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELYADIIMDKPENLAVIETLKQTYDEALTFFEKNDRQGFIDAFHKVRDWFGDYSEQFLKE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRQLLQQANDLKQG
HHHHHHHHHHCCCC
>Mature Secondary Structure
MEALKDLRSEIDSLDRELIQLFAKRLELVSQVGKVKHQHGLPIYAPEREIAMLQARRLEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
EKAGISADLIEDVLRRFMRESYANENQFGFKTINSDIHKIVIVGGYGKLGGLFARYLRAS
HHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCHHHHHHHHHHHHCC
GYPISILDREDWAVAESILANADVVIVSVPINITLETIERLKPYLTENMLLADLTSVKRE
CCCEEEECCCHHHHHHHHHCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
PLAKMLEVHSGAVLGLHPMFGADIASMAKQVVVRCDGRFPERYEWLLEQIQIWGAKIYQT
HHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHEEEC
NATEHDHNMTYIQALRHFSTFANGLHLSKQPVNLANLLALSSPIYRLELAMIGRLFAQDA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHH
ELYADIIMDKPENLAVIETLKQTYDEALTFFEKNDRQGFIDAFHKVRDWFGDYSEQFLKE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SRQLLQQANDLKQG
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]