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The map label for this gene is moaA [H]

Identifier: 148825785

GI number: 148825785

Start: 754751

End: 755764

Strand: Direct

Name: moaA [H]

Synonym: CGSHiEE_03680

Alternate gene names: 148825785

Gene position: 754751-755764 (Clockwise)

Preceding gene: 148825781

Following gene: 148825786

Centisome position: 41.63

GC content: 38.95

Gene sequence:

>1014_bases
ATGCAATCCATTCCTATTAAAAACGTAGGAGAGTCTCGCTTAGTCGATCCTTTCCAACGTCAATATTACTATCTACGACT
GTCGATTACCGATCAGTGCAATTTCCGTTGTACCTATTGTTTACCTGATGGTTATCAACCCGAAGCTAACAAACCGAGTT
TCTTAACCTTAAAAGAAATTACCCATCTTGCTCAAGCGTTTGCTGAAATGGGTACAGAAAAAATCCGTTTAACAGGTGGC
GAACCAACTTTACGTAAAGATTTTATTTCCATTGCTGAAAGCATTGCTAACATTGAGGGCATTCGTCAATTAGCCGTTAC
GACAAACGGCTATCGCATGGCAAAAGATGTGGCTGATTGGAAAAAGGTAGGGATTACGTCTATTAATGTCAGTGTTGATA
GCTTAGATCCAAAAATGTTCCACCAAATTACGGGTATCAATAAATTTGATGATGTGATGCGTGGTATTGATCGGGCATTT
GAAGCGGGCTATAACAAAGTCAAAGTTAATTCAGTTTTAATGAAAAATTTGAATGACAAAGAGTTTGAACAATTCCTTGT
TTGGGTGAAAGATCGCCCAATTCAAATGCGCTTTATTGAGTTGATGCAAACGGGCGAAATGGATAGTTTCTTTGATAGAT
ACCATCTTTCTGGACAAGTCCTAGCGGATAAATTGCTGAAAAATGGTTGGATATTACAGCATAAATCCCACACGGATGGC
CCTGCTAAAGTCTTTACGCATTCTGATTATGCGGGCGAAATTGGTTTAATTATGCCTTATGAAAAGAATTTTTGCGCAAG
TTGCAATCGTTTAAGAGTGTCAGCAAAAGGTAAACTTCATCTCTGTTTATTTGGCGAAGAAGGCATTGAATTACGTGATT
TATTGCAGTCGCACGAACAGCAAGCTATTTTACAAGCGCGTATTTTTGCCGCACTTCAAGGCAAACGTGAACATCATTAT
TTGCATATCGGCGATACTGGTGTAAGAAATCATTTAGCGTCTATCGGTGGCTAA

Upstream 100 bases:

>100_bases
CTAAGTTTCATCGAAATACGGCGACAAGCCAATAACGCAGTTCGTTATTCAGGGATACGCTGGAAACGGTTTATCCTCTC
CGTATTTAGAAAGGTGTAAA

Downstream 100 bases:

>100_bases
AAGCAAAGTGAGATGAATGGTAATATTCATCTGCTTTCTTTTGTCGCTTATTTAAAACATTTAATATTTTAACCGCACTT
TTATCATATTATGACTACAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESIANIEGIRQLAVTTNGYRMAKDVADWKKVGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EAGYNKVKVNSVLMKNLNDKEFEQFLVWVKDRPIQMRFIELMQTGEMDSFFDRYHLSGQVLADKLLKNGWILQHKSHTDG
PAKVFTHSDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQAILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG

Sequences:

>Translated_337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESIANIEGIRQLAVTTNGYRMAKDVADWKKVGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EAGYNKVKVNSVLMKNLNDKEFEQFLVWVKDRPIQMRFIELMQTGEMDSFFDRYHLSGQVLADKLLKNGWILQHKSHTDG
PAKVFTHSDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQAILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG
>Mature_337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESIANIEGIRQLAVTTNGYRMAKDVADWKKVGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EAGYNKVKVNSVLMKNLNDKEFEQFLVWVKDRPIQMRFIELMQTGEMDSFFDRYHLSGQVLADKLLKNGWILQHKSHTDG
PAKVFTHSDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQAILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=335, Percent_Identity=37.3134328358209, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI22027536, Length=335, Percent_Identity=37.3134328358209, Blast_Score=223, Evalue=1e-58,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=61.1620795107034, Blast_Score=437, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI32566331, Length=314, Percent_Identity=36.624203821656, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=314, Percent_Identity=36.624203821656, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=314, Percent_Identity=35.3503184713376, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI28574490, Length=332, Percent_Identity=35.8433734939759, Blast_Score=208, Evalue=4e-54,
Organism=Drosophila melanogaster, GI28574488, Length=320, Percent_Identity=36.25, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38378; Mature: 38378

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEI
CCCCCCCCCCCCCCCCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHHH
THLAQAFAEMGTEKIRLTGGEPTLRKDFISIAESIANIEGIRQLAVTTNGYRMAKDVADW
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
KKVGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAFEAGYNKVKVNSVLMKNLNDK
HHCCEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCHH
EFEQFLVWVKDRPIQMRFIELMQTGEMDSFFDRYHLSGQVLADKLLKNGWILQHKSHTDG
HHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCC
PAKVFTHSDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQ
CCEEEECCCCCCCEEEEECCCCCHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
QAILQARIFAALQGKREHHYLHIGDTGVRNHLASIGG
HHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEI
CCCCCCCCCCCCCCCCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHHH
THLAQAFAEMGTEKIRLTGGEPTLRKDFISIAESIANIEGIRQLAVTTNGYRMAKDVADW
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHH
KKVGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAFEAGYNKVKVNSVLMKNLNDK
HHCCEEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHCCCHH
EFEQFLVWVKDRPIQMRFIELMQTGEMDSFFDRYHLSGQVLADKLLKNGWILQHKSHTDG
HHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCCC
PAKVFTHSDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQ
CCEEEECCCCCCCEEEEECCCCCHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
QAILQARIFAALQGKREHHYLHIGDTGVRNHLASIGG
HHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA