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The map label for this gene is kduD [C]

Identifier: 148825672

GI number: 148825672

Start: 617469

End: 618314

Strand: Direct

Name: kduD [C]

Synonym: CGSHiEE_03060

Alternate gene names: 148825672

Gene position: 617469-618314 (Clockwise)

Preceding gene: 148825671

Following gene: 148825673

Centisome position: 34.06

GC content: 34.04

Gene sequence:

>846_bases
ATGAATATTGCAGCAAACCATAACTTAGAAAATAAACTAATTATAATTACGGGGGCTGGCGGAGTGTTATGTTCATTTCT
AGCTAAGCAGTTAGCGTATACTAAAGCTAATATTGCCCTGTTAGATTTGAATTTCGAGGCAGCAGACAAAGTAGCAAAGG
AAATTAACCAATCAGGTGGAAAAGCAAAAGCTTATAAAACTAATGTGTTAGAACTTGAAAATATTAAAGAAGTGCGTGAT
CAAATAGCTATTGATTTTGGCACTTGTGATATTTTAATTAATGGTGCTGGTGGGAATAATCCAAAAGCGACAACAGATAA
TGAGTTCCATCAATTTGATTTAAATGAAACGACAAGAACATTCTTTGATTTAGATAAATTTGGTATAGAATTTGTATTTA
ATCTCAATTACTTAGGTTCATTATTACCAACCCAAGTTTTTGCAAAAGATATGCTTGGTAAACAAGGGGCAAATATTATT
AATATTTCCAGTATGAATGCCTTTACGCCACTCACAAAGATTCCTGCTTACTCTAGTGCAAAAGCTGCAATCAGTAATTT
TACTCAATGGCTTGCTGTATATTTCTCAAAAGTTGGTATTCGTTGTAATGCTATCGCACCAGGATTTTTAGTTAGTAATC
AAAACCGCGCTTTATTATTTGATACTGAAGGAAAACCAACAGATAGAGCAAATAAAATCCTCACTAACACACCAATGGGA
CGTTTTGGTGAGTCAGAAGAATTGCTCGGTGCATTACTTTTCTTAATAGATGAAAATTATTCTGCTTTTGTCAATGGCGT
GGTTTTACCTGTTGATGGTGGTTTTTCTGCGTATAGTGGAGTCTAA

Upstream 100 bases:

>100_bases
GTAATCGTATTGCTGGCATCGTCATTCAGCATAAAGGTGCGATCATAGATAAAGTCGCAACTTCTCATCTTCAATCTGAA
TTTAATTAATGGAGTTTACT

Downstream 100 bases:

>100_bases
TAGGAGCAAATTAAAATGTCATACACAACTCAACAAATTATTGAAAAACTTCGTGAACTCAAAATTGTGCCTGTAATTGC
GTTGGATAATGCAGACGATA

Product: D-mannonate oxidoreductase

Products: @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate!; NADH. [C]

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MNIAANHNLENKLIIITGAGGVLCSFLAKQLAYTKANIALLDLNFEAADKVAKEINQSGGKAKAYKTNVLELENIKEVRD
QIAIDFGTCDILINGAGGNNPKATTDNEFHQFDLNETTRTFFDLDKFGIEFVFNLNYLGSLLPTQVFAKDMLGKQGANII
NISSMNAFTPLTKIPAYSSAKAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNRALLFDTEGKPTDRANKILTNTPMG
RFGESEELLGALLFLIDENYSAFVNGVVLPVDGGFSAYSGV

Sequences:

>Translated_281_residues
MNIAANHNLENKLIIITGAGGVLCSFLAKQLAYTKANIALLDLNFEAADKVAKEINQSGGKAKAYKTNVLELENIKEVRD
QIAIDFGTCDILINGAGGNNPKATTDNEFHQFDLNETTRTFFDLDKFGIEFVFNLNYLGSLLPTQVFAKDMLGKQGANII
NISSMNAFTPLTKIPAYSSAKAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNRALLFDTEGKPTDRANKILTNTPMG
RFGESEELLGALLFLIDENYSAFVNGVVLPVDGGFSAYSGV
>Mature_281_residues
MNIAANHNLENKLIIITGAGGVLCSFLAKQLAYTKANIALLDLNFEAADKVAKEINQSGGKAKAYKTNVLELENIKEVRD
QIAIDFGTCDILINGAGGNNPKATTDNEFHQFDLNETTRTFFDLDKFGIEFVFNLNYLGSLLPTQVFAKDMLGKQGANII
NISSMNAFTPLTKIPAYSSAKAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNRALLFDTEGKPTDRANKILTNTPMG
RFGESEELLGALLFLIDENYSAFVNGVVLPVDGGFSAYSGV

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=24.8031496062992, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI66933014, Length=276, Percent_Identity=29.3478260869565, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI15277342, Length=280, Percent_Identity=27.1428571428571, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7705925, Length=159, Percent_Identity=29.559748427673, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI31542939, Length=220, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI32483357, Length=266, Percent_Identity=21.8045112781955, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI10190704, Length=270, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI59889578, Length=230, Percent_Identity=26.5217391304348, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789208, Length=271, Percent_Identity=28.0442804428044, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790717, Length=268, Percent_Identity=29.1044776119403, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1787905, Length=269, Percent_Identity=29.368029739777, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787335, Length=268, Percent_Identity=27.6119402985075, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788459, Length=234, Percent_Identity=28.6324786324786, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082160, Length=269, Percent_Identity=26.7657992565056, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI87082100, Length=273, Percent_Identity=25.2747252747253, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367175, Length=236, Percent_Identity=26.271186440678, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=149, Percent_Identity=35.5704697986577, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994604, Length=269, Percent_Identity=27.8810408921933, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=269, Percent_Identity=26.3940520446097, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17536651, Length=268, Percent_Identity=25.7462686567164, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=266, Percent_Identity=29.3233082706767, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=268, Percent_Identity=26.1194029850746, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=26.2948207171315, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538486, Length=197, Percent_Identity=30.9644670050761, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=281, Percent_Identity=25.6227758007117, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17508895, Length=223, Percent_Identity=27.3542600896861, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25147288, Length=270, Percent_Identity=26.2962962962963, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=285, Percent_Identity=27.719298245614, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=281, Percent_Identity=25.9786476868327, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=269, Percent_Identity=23.0483271375465, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17551412, Length=213, Percent_Identity=29.5774647887324, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=283, Percent_Identity=25.4416961130742, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=278, Percent_Identity=27.6978417266187, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=281, Percent_Identity=25.9786476868327, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=203, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=262, Percent_Identity=30.9160305343511, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=273, Percent_Identity=26.3736263736264, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544670, Length=275, Percent_Identity=24.7272727272727, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=283, Percent_Identity=24.3816254416961, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=205, Percent_Identity=26.3414634146341, Blast_Score=64, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=271, Percent_Identity=24.3542435424354, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI23397609, Length=268, Percent_Identity=28.3582089552239, Blast_Score=101, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21357041, Length=273, Percent_Identity=25.2747252747253, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI28571526, Length=273, Percent_Identity=25.6410256410256, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24644339, Length=277, Percent_Identity=27.0758122743682, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24639444, Length=270, Percent_Identity=26.2962962962963, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24643142, Length=270, Percent_Identity=28.5185185185185, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24644337, Length=271, Percent_Identity=28.0442804428044, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21355319, Length=271, Percent_Identity=24.3542435424354, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24649181, Length=225, Percent_Identity=24, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.125 [C]

Molecular weight: Translated: 30486; Mature: 30486

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAANHNLENKLIIITGAGGVLCSFLAKQLAYTKANIALLDLNFEAADKVAKEINQSGG
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCC
KAKAYKTNVLELENIKEVRDQIAIDFGTCDILINGAGGNNPKATTDNEFHQFDLNETTRT
CCEEEEECCEEHHHHHHHHHHHEEEECEEEEEEECCCCCCCCCCCCCCCEEECCCCHHHH
FFDLDKFGIEFVFNLNYLGSLLPTQVFAKDMLGKQGANIINISSMNAFTPLTKIPAYSSA
HHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCH
KAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNRALLFDTEGKPTDRANKILTNTPMG
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEEECCCCEEEEECCCCCCHHHCEEECCCCCC
RFGESEELLGALLFLIDENYSAFVNGVVLPVDGGFSAYSGV
CCCCHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCHHCCCC
>Mature Secondary Structure
MNIAANHNLENKLIIITGAGGVLCSFLAKQLAYTKANIALLDLNFEAADKVAKEINQSGG
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHCCC
KAKAYKTNVLELENIKEVRDQIAIDFGTCDILINGAGGNNPKATTDNEFHQFDLNETTRT
CCEEEEECCEEHHHHHHHHHHHEEEECEEEEEEECCCCCCCCCCCCCCCEEECCCCHHHH
FFDLDKFGIEFVFNLNYLGSLLPTQVFAKDMLGKQGANIINISSMNAFTPLTKIPAYSSA
HHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHCCCCCCH
KAAISNFTQWLAVYFSKVGIRCNAIAPGFLVSNQNRALLFDTEGKPTDRANKILTNTPMG
HHHHHHHHHHHHHHHHHHCCEEECCCCCEEEECCCCEEEEECCCCCCHHHCEEECCCCCC
RFGESEELLGALLFLIDENYSAFVNGVVLPVDGGFSAYSGV
CCCCHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 15.4 {2-deoxygluconate}} [C]

Substrates: @DEOX03.txt*2-Deoxy-D-Gluconate!; NAD(+) [C]

Specific reaction: @DEOX03.txt*2-Deoxy-D-Gluconate! + NAD(+) = @DEHY06.txt*3-Dehydro-2- Deoxy-D-Gluconate! + NADH. [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]