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The map label for this gene is gpsA

Identifier: 148825501

GI number: 148825501

Start: 388195

End: 389202

Strand: Direct

Name: gpsA

Synonym: CGSHiEE_02000

Alternate gene names: 148825501

Gene position: 388195-389202 (Clockwise)

Preceding gene: 148825500

Following gene: 148825502

Centisome position: 21.41

GC content: 42.26

Gene sequence:

>1008_bases
ATGATAACTTCGCAAACACCAATCACTGTGCTAGGTGCGGGATCTTATGGAACTGCGCTGGCAATTACCTTTTCTCGCAA
TGGTTCTCCCACTCACTTATGGGGGCACAATCCCGTCCATATCGCACAAATGCAGACAGAACGACAAAATTATCGTTTTT
TGCCGGATGTCATCTTTCCTGAGGATCTTCATTTAGAAAGTAATCTTGCACAAGCAATGGAATATTCTCAAGATATTTTA
ATCGTGGTGCCAAGCCATGCTTTCGGTGAAATTCTTATAAAAATTAAACCGCACTTAAAAGCCCATCACCGATTAATTTG
GGCAACAAAAGGTCTGGAGCGTAACACAGGGCGTTTACTACAAACCGTAGTTGAAGAACAACTCGGAACGCAATATCCAC
TAGCTGTACTTTCTGGCCCAACTTTTGCAAAAGAATTAGCGCAAGGTCTACCATCAGCTATTACGCTTGCTGCCAATAAC
GAGCAATTCGCGCGGGAATTTCAGTCTCGTATTCATTGTAGTAAAGGTTTCCGAGTTTATATAAATTCGGATATGACTGG
CGTTCAACTTGGTGGTGCAATTAAAAATGTGATCGCAATTGGTGCGGGTATTTCAGACGGTATGGGATTTGGCGCAAATG
CTCGCACAGCACTGATTACTCGAGGTATTGCAGAAATTACCCGCTTAGGTATCTCGCTCGGTGCAAATACCAATACATTT
ATGGGAATGTCTGGATTGGGCGATTTAGTGCTAACTTGCACCGATAATCAATCGCGCAATCGACGTTTTGGATTAATGCT
AGGTAAAGGATTAGATGCCCAAATGGCTATGGAAAATATCGGGCAAGTCGTAGAAGGTTTTTATAATACAAAAGAAGCCT
ATTTGCTTGCACAAAGACAAGGTGTGGAAATGCCGATTACAGAACAAATTTATCAAATGCTGTTTTGTGGCAAAAACGCA
CAAGATGTAGCAATCAGCCTTTTGGGGCGAGCATGTAAAGGCGAATAA

Upstream 100 bases:

>100_bases
TTTAAATTCCGCCAAATGAATAAGTAATATTTTCCTGTGGTTGATAGGTTACCGAAAGATATCTATACTTATTTCCTCTT
TTACTAGATAAATTGTAGAT

Downstream 100 bases:

>100_bases
AATAAAAGGAGAAATTATGACATTAGATGTGTGGCAACATATTCGCCAAGAAGCCAAAGAACTTGCTGAAAACGAACCTA
TGCTTGCTAGTTTTTTTCAC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MITSQTPITVLGAGSYGTALAITFSRNGSPTHLWGHNPVHIAQMQTERQNYRFLPDVIFPEDLHLESNLAQAMEYSQDIL
IVVPSHAFGEILIKIKPHLKAHHRLIWATKGLERNTGRLLQTVVEEQLGTQYPLAVLSGPTFAKELAQGLPSAITLAANN
EQFAREFQSRIHCSKGFRVYINSDMTGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGIAEITRLGISLGANTNTF
MGMSGLGDLVLTCTDNQSRNRRFGLMLGKGLDAQMAMENIGQVVEGFYNTKEAYLLAQRQGVEMPITEQIYQMLFCGKNA
QDVAISLLGRACKGE

Sequences:

>Translated_335_residues
MITSQTPITVLGAGSYGTALAITFSRNGSPTHLWGHNPVHIAQMQTERQNYRFLPDVIFPEDLHLESNLAQAMEYSQDIL
IVVPSHAFGEILIKIKPHLKAHHRLIWATKGLERNTGRLLQTVVEEQLGTQYPLAVLSGPTFAKELAQGLPSAITLAANN
EQFAREFQSRIHCSKGFRVYINSDMTGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGIAEITRLGISLGANTNTF
MGMSGLGDLVLTCTDNQSRNRRFGLMLGKGLDAQMAMENIGQVVEGFYNTKEAYLLAQRQGVEMPITEQIYQMLFCGKNA
QDVAISLLGRACKGE
>Mature_335_residues
MITSQTPITVLGAGSYGTALAITFSRNGSPTHLWGHNPVHIAQMQTERQNYRFLPDVIFPEDLHLESNLAQAMEYSQDIL
IVVPSHAFGEILIKIKPHLKAHHRLIWATKGLERNTGRLLQTVVEEQLGTQYPLAVLSGPTFAKELAQGLPSAITLAANN
EQFAREFQSRIHCSKGFRVYINSDMTGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGIAEITRLGISLGANTNTF
MGMSGLGDLVLTCTDNQSRNRRFGLMLGKGLDAQMAMENIGQVVEGFYNTKEAYLLAQRQGVEMPITEQIYQMLFCGKNA
QDVAISLLGRACKGE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=339, Percent_Identity=27.7286135693215, Blast_Score=121, Evalue=9e-28,
Organism=Homo sapiens, GI24307999, Length=348, Percent_Identity=24.7126436781609, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1790037, Length=328, Percent_Identity=67.9878048780488, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI32564399, Length=334, Percent_Identity=25.748502994012, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI193210136, Length=343, Percent_Identity=25.3644314868805, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32564403, Length=343, Percent_Identity=25.3644314868805, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17507425, Length=349, Percent_Identity=22.3495702005731, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI193210134, Length=331, Percent_Identity=22.3564954682779, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320181, Length=341, Percent_Identity=28.1524926686217, Blast_Score=116, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6324513, Length=353, Percent_Identity=25.2124645892351, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI22026922, Length=332, Percent_Identity=24.0963855421687, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17136204, Length=340, Percent_Identity=25.8823529411765, Blast_Score=88, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136202, Length=340, Percent_Identity=25.8823529411765, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17136200, Length=340, Percent_Identity=25.8823529411765, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551945, Length=237, Percent_Identity=27.8481012658228, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281362270, Length=237, Percent_Identity=27.8481012658228, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24648969, Length=190, Percent_Identity=28.9473684210526, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_HAEI8 (Q4QMJ1)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248416.1
- ProteinModelPortal:   Q4QMJ1
- SMR:   Q4QMJ1
- STRING:   Q4QMJ1
- GeneID:   3430168
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0860
- eggNOG:   COG0240
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- PhylomeDB:   Q4QMJ1
- ProtClustDB:   PRK00094
- BioCyc:   HINF281310:NTHI0860-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36450; Mature: 36450

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 195-195 BINDING 110-110 BINDING 110-110 BINDING 143-143 BINDING 259-259 BINDING 285-285

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSQTPITVLGAGSYGTALAITFSRNGSPTHLWGHNPVHIAQMQTERQNYRFLPDVIFP
CCCCCCCEEEEECCCCCCEEEEEEECCCCCCEECCCCCEEEEEEHHCCCCCEECCCCCCC
EDLHLESNLAQAMEYSQDILIVVPSHAFGEILIKIKPHLKAHHRLIWATKGLERNTGRLL
CCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHCEEEEEECCCCCCHHHHH
QTVVEEQLGTQYPLAVLSGPTFAKELAQGLPSAITLAANNEQFAREFQSRIHCSKGFRVY
HHHHHHHHCCCCCCCEECCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEE
INSDMTGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGIAEITRLGISLGANTNTF
ECCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
MGMSGLGDLVLTCTDNQSRNRRFGLMLGKGLDAQMAMENIGQVVEGFYNTKEAYLLAQRQ
EECCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHEEEEHHC
GVEMPITEQIYQMLFCGKNAQDVAISLLGRACKGE
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITSQTPITVLGAGSYGTALAITFSRNGSPTHLWGHNPVHIAQMQTERQNYRFLPDVIFP
CCCCCCCEEEEECCCCCCEEEEEEECCCCCCEECCCCCEEEEEEHHCCCCCEECCCCCCC
EDLHLESNLAQAMEYSQDILIVVPSHAFGEILIKIKPHLKAHHRLIWATKGLERNTGRLL
CCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCHHCEEEEEECCCCCCHHHHH
QTVVEEQLGTQYPLAVLSGPTFAKELAQGLPSAITLAANNEQFAREFQSRIHCSKGFRVY
HHHHHHHHCCCCCCCEECCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEE
INSDMTGVQLGGAIKNVIAIGAGISDGMGFGANARTALITRGIAEITRLGISLGANTNTF
ECCCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
MGMSGLGDLVLTCTDNQSRNRRFGLMLGKGLDAQMAMENIGQVVEGFYNTKEAYLLAQRQ
EECCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHEEEEHHC
GVEMPITEQIYQMLFCGKNAQDVAISLLGRACKGE
CCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA