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The map label for this gene is galE [H]

Identifier: 148825365

GI number: 148825365

Start: 234693

End: 235709

Strand: Direct

Name: galE [H]

Synonym: CGSHiEE_01245

Alternate gene names: 148825365

Gene position: 234693-235709 (Clockwise)

Preceding gene: 148825364

Following gene: 148825366

Centisome position: 12.94

GC content: 37.86

Gene sequence:

>1017_bases
ATGGCCATTTTAGTTACAGGTGGCGCTGGTTATATCGGTTCTCACACAGTTGTAGAATTATTAAATGTTGGCAAAAAGGT
GGTAGTATTAGATAATCTTTGCAATTCATCGCCAAAATCCCTTGAGCGTGTAAAACAAATTACAGGCAAAGAAGCAAAGT
TTTATGAAGGCGATATTTTAGATCGTGCTTTGTTACAAAAAATTTTTGCAGAAAATGAGATTAACTCGGTTATTCACTTT
GCTGGATTGAAAGCTGTAGGGGAAAGTGTTCAAAAACCAACAGAATATTATATGAACAATGTCGCTGGCACCCTTGTATT
AATTCAAGAAATGAAAAGAGCGGGTGTTTGGAACTTTGTATTTAGCTCATCTGCAACGGTTTACGGCGATCCAAAAATTA
TTCCAATTACAGAGGATTGTGAAGTCGGCGGTACAACCAACCCTTATGGTACATCTAAATATATGGTTGAGCAGATTTTA
CGCGATACAGCAAAAGCGGAACCAAAATTTAGCATGACCATCTTGCGTTATTTTAATCCAGTTGGGGCACATGAAAGTGG
CTTGATTGGTGAAGATCCAAATGGTATTCCAAATAATTTATTACCTTATATTAGCCAAGTTGCTATCGGTAAATTAGCAC
AACTTTCTGTATTTGGTAGTGATTACGACACTCATGATGGAACAGGTGTGCGTGATTATATTCATGTAGTGGATTTAGCA
GTGGGGCATTTAAAAGCGCTTCAACGTCATGAAAATGACGCTGGTTTACATATTTATAACCTTGGTACGGGCCATGGTTA
TTCCGTATTAGATATGGTAAAAGCCTTTGAAAAAGCCAATAATATTACAATTGCATATAAACTTGTAGAACGCCGCTCTG
GCGATATTGCCACTTGCTATTCTGATCCTAGTTTAGCTGCAAAAGAGCTTGGTTGGGTGGCAGAACGTGGTCTTGAAAAA
ATGATGCAAGACACGTGGAACTGGCAGAAAAATAATCCAAAAGGGTATAGAGATTAA

Upstream 100 bases:

>100_bases
TTTTTAGCAACAGGTTTTTTATTTTATTGAAAATCACCATTCTTACCACACAAAATAGTGATATAATTTTTTAGTCTCAA
TAATTAATAAGGAGATCATT

Downstream 100 bases:

>100_bases
TATTCTCTAATATTTGTTTTTCTTTTTTAGGAAGAAGAATGCTAAACATTGGGGGAATGATTAAAAATCCCCTAATTTTT
ACAAAAATCCTTTAATTGAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MAILVTGGAGYIGSHTVVELLNVGKKVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHF
AGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKRAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQIL
RDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEK
MMQDTWNWQKNNPKGYRD

Sequences:

>Translated_338_residues
MAILVTGGAGYIGSHTVVELLNVGKKVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHF
AGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKRAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQIL
RDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEK
MMQDTWNWQKNNPKGYRD
>Mature_337_residues
AILVTGGAGYIGSHTVVELLNVGKKVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHFA
GLKAVGESVQKPTEYYMNNVAGTLVLIQEMKRAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILR
DTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLAV
GHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEKM
MQDTWNWQKNNPKGYRD

Specific function: By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae [H]

COG id: COG1087

COG function: function code M; UDP-glucose 4-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=340, Percent_Identity=59.1176470588235, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI56118217, Length=340, Percent_Identity=59.1176470588235, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI189083684, Length=340, Percent_Identity=59.1176470588235, Blast_Score=423, Evalue=1e-118,
Organism=Homo sapiens, GI7657641, Length=348, Percent_Identity=26.1494252873563, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786974, Length=338, Percent_Identity=57.6923076923077, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788353, Length=367, Percent_Identity=25.8855585831063, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI48994969, Length=364, Percent_Identity=27.4725274725275, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71982035, Length=345, Percent_Identity=57.6811594202899, Blast_Score=399, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71982038, Length=347, Percent_Identity=57.3487031700288, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17568069, Length=283, Percent_Identity=28.2685512367491, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319493, Length=344, Percent_Identity=53.4883720930233, Blast_Score=362, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19923002, Length=342, Percent_Identity=59.3567251461988, Blast_Score=432, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 37193; Mature: 37062

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILVTGGAGYIGSHTVVELLNVGKKVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL
CEEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHH
DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKRAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNP
ECCCCEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHH
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCY
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHCCCCEEEEE
SDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AILVTGGAGYIGSHTVVELLNVGKKVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDIL
EEEEECCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHH
DRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKRAGVWNFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEEE
FSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNP
ECCCCEEECCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
VGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLA
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHH
VGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCY
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEEEEEEHHCCCCEEEEE
SDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1956282; 7542800 [H]