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The map label for this gene is menA [H]

Identifier: 148825213

GI number: 148825213

Start: 88616

End: 89527

Strand: Direct

Name: menA [H]

Synonym: CGSHiEE_00445

Alternate gene names: 148825213

Gene position: 88616-89527 (Clockwise)

Preceding gene: 148825211

Following gene: 148825214

Centisome position: 4.89

GC content: 39.69

Gene sequence:

>912_bases
ATGACAAATGAAAAATTGAAAATGTGGTGGGAAACGGCTCGACCAAAAACTTTGCCCTTAGCGTTGGCATCGATTTTCAC
GGGTTCGGCATTAGGTTATTGGGCGAATCCACAAGGTTTTAATGGGCTTGTAATGGCGCTTTGTTTACTCACGACAATTT
TATTGCAGGTGCTTTCTAATTTTGCCAATGATTATGGGGATCATCAAAAAGGTTCAGATACTGAAGAACGTATTGGGCCA
TTACGTGGCATTCAAAAAGGCGCAATTTCAGCCAAAGAACTGAAATGGGGATTAATTCTAATGGTGATGGCAAGTTTTCT
TTCAGGAAGTTTCTTGATTGGAATCGCTTATGAAAATCTCTCAGATTTATTCGCTTTCGCTGGGCTTGGAATTTTAGCTA
TTGTTGCTGCCATTACTTACACAGTTGGGGTAAAACCTTATGGCTATATGGGCTTGGGCGATATTTCTGTGTTGGTATTT
TTTGGTTTGCTTGGTGTTGGCGGTACTTATTATTTGCAAACTCACAGTATTGCTAGCCACATTATTTTGCCTGCTATTGG
TTCTGGCTTATTGGCAAGTGCGGTATTAAATATCAATAATTTACGCGATATTGAACAGGATGCGAAAGCTGGCAAAAACA
CCCTAGCCGTTCGTTTAGGTGCATATAAGGGGCGTGTTTATCATTGTATTTTATTAAGTGTGGCTGCCTTATGTTATTTA
GCATTTGCGGTGGCAACGGCCATTTCTTGGACAAATTATTTATTTGTATTGGCAATGCCGTTGTTGGCTAAACATGCGAT
CTTTGTTTATCGCAGTCAGCAGCCAAGTGAATTGCGTCCAATGTTGGCTCAAATGTCTATGATTTCGTTATTAATCAATA
TCTTGTTTAGTTTAGGCTTGCTTATCGGCTAA

Upstream 100 bases:

>100_bases
GTGGATAATGGCGACAGGCGATAAAGTTAAATCATTCATAAATTGGGTGTCTTAGTGTAGAATACGCGGCCTATTGTAAT
CAAAAGTGCGGTCAAAAAAA

Downstream 100 bases:

>100_bases
ATCGGCATATACTAAAGCAAACAAAATTTCAACAATCGATAGGGAAAGTTATGTTTATTGATACTTCAGAACTTTGCGAT
CTTTATGCAGAACAAGTGGA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTNEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMALCLLTTILLQVLSNFANDYGDHQKGSDTEERIGP
LRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVF
FGLLGVGGTYYLQTHSIASHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
AFAVATAISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG

Sequences:

>Translated_303_residues
MTNEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMALCLLTTILLQVLSNFANDYGDHQKGSDTEERIGP
LRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVF
FGLLGVGGTYYLQTHSIASHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
AFAVATAISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG
>Mature_302_residues
TNEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMALCLLTTILLQVLSNFANDYGDHQKGSDTEERIGPL
RGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENLSDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFF
GLLGVGGTYYLQTHSIASHIILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYLA
FAVATAISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGLLIG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=309, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790365, Length=306, Percent_Identity=52.6143790849673, Blast_Score=294, Evalue=4e-81,
Organism=Drosophila melanogaster, GI17737429, Length=302, Percent_Identity=26.8211920529801, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32702; Mature: 32571

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMALCLLTTILLQVLSN
CCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FANDYGDHQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENL
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH
SDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIASH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHH
IILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AFAVATAISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIG
HCC
>Mature Secondary Structure 
TNEKLKMWWETARPKTLPLALASIFTGSALGYWANPQGFNGLVMALCLLTTILLQVLSN
CCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
FANDYGDHQKGSDTEERIGPLRGIQKGAISAKELKWGLILMVMASFLSGSFLIGIAYENL
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEHHHH
SDLFAFAGLGILAIVAAITYTVGVKPYGYMGLGDISVLVFFGLLGVGGTYYLQTHSIASH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEHHHHHHH
IILPAIGSGLLASAVLNINNLRDIEQDAKAGKNTLAVRLGAYKGRVYHCILLSVAALCYL
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
AFAVATAISWTNYLFVLAMPLLAKHAIFVYRSQQPSELRPMLAQMSMISLLINILFSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LIG
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]