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The map label for this gene is lytC [H]

Identifier: 148825123

GI number: 148825123

Start: 4416196

End: 4417416

Strand: Direct

Name: lytC [H]

Synonym: TBFG_13950

Alternate gene names: 148825123

Gene position: 4416196-4417416 (Clockwise)

Preceding gene: 148825122

Following gene: NA

Centisome position: 99.81

GC content: 62.74

Gene sequence:

>1221_bases
ATGCCGAGTCCGCGCCGCGAAGACGGCGATGCGCTGCGCTGTGGCGACCGCAGTGCGGCCGTCACCGAGATCCGGGCTGC
GCTGACCGCGTTAGGGATGCTGGATCATCAGGAAGAAGACCTGACGACGGGCCGTAACGTCGCCCTTGAGTTGTTCGACG
CGCAGCTCGACCAGGCGGTCCGTGCCTTCCAACAGCATCGCGGCCTGCTGGTGGACGGCATCGTCGGTGAGGCCACCTAC
CGCGCGTTGAAAGAAGCCTCCTACCGGCTCGGGGCCCGCACGCTGTACCACCAATTCGGCGCCCCGCTCTACGGGGACGA
CGTCGCTACACTGCAGGCCCGGCTGCAGGATCTTGGTTTCTACACCGGGCTGGTCGACGGTCATTTCGGGTTGCAGACCC
ACAATGCGTTGATGTCCTATCAGCGTGAGTACGGACTTGCCGCAGACGGTATCTGCGGCCCAGAAACGTTGCGCTCCTTG
TACTTTCTAAGTTCGCGAGTCAGCGGTGGCTCGCCACATGCGATTCGCGAAGAAGAGCTGGTCCGCAGCTCGGGGCCGAA
GCTGTCTGGCAAACGGATCATCATTGATCCCGGTCGCGGCGGCGTGGACCACGGACTTATCGCGCAAGGTCCGGCTGGGC
CCATCAGCGAAGCAGACTTGTTGTGGGACTTGGCAAGTCGGCTCGAAGGACGGATGGCAGCTATCGGTATGGAGACCCAC
CTGTCCCGTCCGACCAACCGTAGTCCGTCCGACGCAGAGCGTGCCGCCACCGCCAACGCCGTTGGCGCAGACCTGATGAT
CAGCCTGCGCTGCGAGACCCAGACCAGTCTCGCGGCCAACGGCGTGGCTTCCTTTCACTTCGGCAACTCGCACGGCTCGG
TGTCTACCATCGGCCGCAATCTTGCCGATTTCATTCAACGAGAAGTGGTGGCGCGCACCGGTTTACGGGATTGCCGTGTG
CATGGTCGAACGTGGGATCTGTTGCGGCTGACCAGGATGCCGACCGTTCAGGTCGATATCGGCTACATCACCAACCCCCA
CGATCGTGGGATGCTGGTCTCAACGCAGACGCGCGATGCCATCGCCGAAGGCATTCTCGCCGCGGTCAAACGGCTGTATC
TGTTAGGCAAGAACGATCGGCCCACCGGCACATTCACTTTCGCCGAGTTGCTGGCCCACGAACTGTCTGTCGAGCGAGCG
GGTAGACTCGGCGGTTCTTAA

Upstream 100 bases:

>100_bases
TTAGCCTGGGGTTTTCCCGAAATCGGCAAGGATCTGCGACAATACCGGTTGGCTGGTCCGCATTGTCAACGATGTGAGCT
AATCCCGGAGGGCCCTTGGT

Downstream 100 bases:

>100_bases
GCCCAGTGGCCGCGTGGGGTTTACGACGTGTTGCCGGCCGTCGACCCCGCTGCTATCGGCTCTTGCAGTCGAGCATTCTC
CAGCAAGCGTTCAAGAGCGG

Product: hydrolase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATY
RALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSL
YFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH
LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRV
HGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERA
GRLGGS

Sequences:

>Translated_406_residues
MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATY
RALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSL
YFLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH
LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRV
HGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERA
GRLGGS
>Mature_405_residues
PSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAVRAFQQHRGLLVDGIVGEATYR
ALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGFYTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLY
FLSSRVSGGSPHAIREEELVRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETHL
SRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRNLADFIQREVVARTGLRDCRVH
GRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDAIAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAG
RLGGS

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 43912; Mature: 43781

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAV
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
RAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGF
HHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
YTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLYFLSSRVSGGSPHAIREEEL
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
VRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH
HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHEECHHHH
LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRN
CCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCEEEEECCCCCCHHHHHHH
LADFIQREVVARTGLRDCRVHGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDA
HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHCCCEEEEEECEEECCCCCCEEEECCHHHH
IAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAGRLGGS
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSPRREDGDALRCGDRSAAVTEIRAALTALGMLDHQEEDLTTGRNVALELFDAQLDQAV
CCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHH
RAFQQHRGLLVDGIVGEATYRALKEASYRLGARTLYHQFGAPLYGDDVATLQARLQDLGF
HHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
YTGLVDGHFGLQTHNALMSYQREYGLAADGICGPETLRSLYFLSSRVSGGSPHAIREEEL
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHH
VRSSGPKLSGKRIIIDPGRGGVDHGLIAQGPAGPISEADLLWDLASRLEGRMAAIGMETH
HHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHEECHHHH
LSRPTNRSPSDAERAATANAVGADLMISLRCETQTSLAANGVASFHFGNSHGSVSTIGRN
CCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHCCCEEEEECCCCCCHHHHHHH
LADFIQREVVARTGLRDCRVHGRTWDLLRLTRMPTVQVDIGYITNPHDRGMLVSTQTRDA
HHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHCCCEEEEEECEEECCCCCCEEEECCHHHH
IAEGILAAVKRLYLLGKNDRPTGTFTFAELLAHELSVERAGRLGGS
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]