Click here to switch to the map view.

The map label for this gene is eccA1

Identifier: 148825076

GI number: 148825076

Start: 4356314

End: 4358035

Strand: Direct

Name: eccA1

Synonym: TBFG_13903

Alternate gene names: 148825076

Gene position: 4356314-4358035 (Clockwise)

Preceding gene: 148825075

Following gene: 148825077

Centisome position: 98.46

GC content: 64.4

Gene sequence:

>1722_bases
ATGACTGATCGCTTGGCCAGTCTGTTCGAAAGCGCCGTCAGCATGTTGCCGATGTCGGAGGCGCGGTCGCTAGATCTGTT
CACCGAGATCACCAACTACGACGAATCCGCTTGCGACGCATGGATCGGCCGGATCCGGTGTGGGGACACCGACCGGGTGA
CGCTGTTTCGCGCCTGGTATTCGCGCCGCAATTTCGGACAGTTGTCGGGATCGGTCCAGATCTCGATGAGCACGTTAAAC
GCCAGGATTGCCATCGGGGGGCTGTACGGCGATATCACCTACCCGGTCACCTCGCCGCTAGCGATCACCATGGGCTTTGC
CGCATGCGAGGCAGCGCAAGGCAATTACGCCGACGCCATGGAGGCCTTAGAGGCCGCCCCGGTCGCGGGTTCCGAGCACC
TGGTGGCGTGGATGAAGGCGGTTGTCTACGGCGCGGCCGAACGCTGGACCGACGTGATCGACCAGGTCAAGAGTGCTGGG
AAATGGCCGGACAAGTTTTTGGCCGGCGCGGCCGGTGTGGCGCACGGGGTTGCCGCGGCAAACCTGGCCTTGTTCACCGA
AGCCGAACGCCGACTCACCGAGGCCAACGACTCGCCCGCCGGTGAGGCGTGTGCGCGCGCCATCGCCTGGTATCTGGCGA
TGGCACGGCGCAGCCAGGGCAACGAAAGCGCCGCGGTGGCGCTGCTGGAATGGTTACAGACCACTCACCCCGAGCCCAAA
GTGGCTGCGGCGCTGAAGGATCCCTCCTACCGGCTGAAGACGACCACCGCCGAACAGATCGCATCCCGCGCCGATCCCTG
GGATCCGGGCAGTGTCGTGACCGACAACTCCGGCCGGGAGCGGCTGCTCGCCGAGGCCCAAGCCGAACTCGACCGCCAAA
TTGGGCTCACCCGGGTTAAAAATCAGATTGAACGCTACCGCGCGGCGACGCTGATGGCCCGGGTCCGCGCCGCCAAGGGT
ATGAAGGTCGCCCAGCCCAGCAAGCACATGATCTTCACCGGACCGCCCGGTACCGGCAAGACCACGATCGCGCGGGTGGT
GGCCAATATCCTGGCCGGCTTAGGCGTCATTGCCGAACCCAAACTCGTCGAGACGTCGCGCAAGGACTTCGTCGCCGAGT
ACGAGGGGCAATCGGCGGTCAAGACCGCTAAGACGATCGATCAGGCGCTGGGCGGGGTGCTTTTCATCGACGAGGCTTAT
GCGCTGGTGCAGGAAAGAGACGGCCGCACCGATCCGTTCGGTCAAGAGGCGCTGGACACGCTGCTGGCGCGGATGGAGAA
CGACCGGGACCGGCTGGTGGTGATCATCGCCGGGTACAGCTCCGACATAGATCGGCTGCTGGAAACCAACGAGGGTCTGC
GGTCGCGGTTCGCCACTCGCATCGAGTTCGACACCTATTCCCCCGAGGAACTCCTCGAGATCGCCAACGTCATTGCCGCT
GCTGATGATTCGGCGTTGACCGCAGAGGCGGCCGAGAACTTTCTTCAGGCCGCCAAGCAGTTGGAGCAGCGCATGTTGCG
CGGCCGGCGCGCCCTGGACGTCGCCGGCAACGGTCGGTATGCGCGCCAGCTGGTGGAGGCCAGCGAGCAATGCCGGGACA
TGCGTCTAGCCCAGGTCCTCGATATCGACACCCTCGACGAAGACCGGCTTCGCGAGATCAACGGCTCAGATATGGCGGAG
GCTATCGCCGCGGTGCACGCACACCTCAACATGAGAGAATGA

Upstream 100 bases:

>100_bases
ATGACCCTGAATCTGCCGACGCCGGAAGAGGCTGCCGCAGCCGAAGCCGAAGTGTTCGCCACCCGCTACGATGTCGACTA
CACCTCCCGGTACAAGGCCG

Downstream 100 bases:

>100_bases
ACTATGGGGCTTCGCCTCACCACCAAGGTTCAGGTTAGCGGCTGGCGTTTTCTGCTGCGCCGGCTCGAACACGCCATCGT
GCGCCGGGACACCCGGATGT

Product: hypothetical protein

Products: NA

Alternate protein names: ESX conserved component A1; Type VII secretion system protein EccA1; T7SS protein EccA1

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLN
ARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAG
KWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
VAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKG
MKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAY
ALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAE
AIAAVHAHLNMRE

Sequences:

>Translated_573_residues
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLN
ARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAG
KWPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
VAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKG
MKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAY
ALVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAE
AIAAVHAHLNMRE
>Mature_572_residues
TDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWYSRRNFGQLSGSVQISMSTLNA
RIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAMEALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGK
WPDKFLAGAAGVAHGVAAANLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPKV
AAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVKNQIERYRAATLMARVRAAKGM
KVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEPKLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYA
LVQERDGRTDPFGQEALDTLLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAAA
DDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVLDIDTLDEDRLREINGSDMAEA
IAAVHAHLNMRE

Specific function: Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cbxX/cfxQ family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECCA1_MYCTU (O69733)

Other databases:

- EMBL:   BX842584
- EMBL:   AE000516
- PIR:   B70802
- RefSeq:   NP_218385.1
- RefSeq:   NP_338535.1
- ProteinModelPortal:   O69733
- EnsemblBacteria:   EBMYCT00000003706
- EnsemblBacteria:   EBMYCT00000072761
- GeneID:   886199
- GeneID:   922551
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3981
- KEGG:   mtu:Rv3868
- TIGR:   MT3981
- TubercuList:   Rv3868
- GeneTree:   EBGT00050000015038
- HOGENOM:   HBG569278
- OMA:   SACDAWV
- ProtClustDB:   CLSK792773
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR000641
- PRINTS:   PR00819
- SMART:   SM00382

Pfam domain/function: PF00004 AAA

EC number: NA

Molecular weight: Translated: 62426; Mature: 62295

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWY
CCHHHHHHHHHHHHHCCCHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
SRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAM
HCCCCCCCCCEEEEEEEECCEEEEEEEEECCEECCCCCCHHHHHHHHHHHCCCCCHHHHH
EALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCH
VAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVK
HHHHCCCCCCEEECCHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
KLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCHHHHHH
LLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
HHHHHCCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
CCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TDRLASLFESAVSMLPMSEARSLDLFTEITNYDESACDAWIGRIRCGDTDRVTLFRAWY
CHHHHHHHHHHHHHCCCHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHH
SRRNFGQLSGSVQISMSTLNARIAIGGLYGDITYPVTSPLAITMGFAACEAAQGNYADAM
HCCCCCCCCCEEEEEEEECCEEEEEEEEECCEECCCCCCHHHHHHHHHHHCCCCCHHHHH
EALEAAPVAGSEHLVAWMKAVVYGAAERWTDVIDQVKSAGKWPDKFLAGAAGVAHGVAAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
NLALFTEAERRLTEANDSPAGEACARAIAWYLAMARRSQGNESAAVALLEWLQTTHPEPK
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCH
VAAALKDPSYRLKTTTAEQIASRADPWDPGSVVTDNSGRERLLAEAQAELDRQIGLTRVK
HHHHCCCCCCEEECCHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
NQIERYRAATLMARVRAAKGMKVAQPSKHMIFTGPPGTGKTTIARVVANILAGLGVIAEP
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCC
KLVETSRKDFVAEYEGQSAVKTAKTIDQALGGVLFIDEAYALVQERDGRTDPFGQEALDT
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEHHHHHHHHHHCCCCCCCCCHHHHHH
LLARMENDRDRLVVIIAGYSSDIDRLLETNEGLRSRFATRIEFDTYSPEELLEIANVIAA
HHHHHCCCCCEEEEEEECCCHHHHHHHHCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHH
ADDSALTAEAAENFLQAAKQLEQRMLRGRRALDVAGNGRYARQLVEASEQCRDMRLAQVL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DIDTLDEDRLREINGSDMAEAIAAVHAHLNMRE
CCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036