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The map label for this gene is folK [H]

Identifier: 148824811

GI number: 148824811

Start: 4060962

End: 4061528

Strand: Reverse

Name: folK [H]

Synonym: TBFG_13638

Alternate gene names: 148824811

Gene position: 4061528-4060962 (Counterclockwise)

Preceding gene: 148824812

Following gene: 148824810

Centisome position: 91.8

GC content: 67.2

Gene sequence:

>567_bases
ATGACGCGGGTAGTGCTCTCGGTTGGCTCCAACCTGGGTGACCGCCTGGCACGATTGCGGTCGGTCGCCGACGGTCTCGG
CGATGCGTTGATTGCGGCTTCCCCGATATATGAGGCCGACCCCTGGGGTGGGGTGGAGCAGGGGCAGTTCCTCAATGCGG
TGCTGATCGCCGACGATCCTACCTGCGAACCGCGGGAGTGGCTGCGGCGGGCGCAGGAGTTCGAGCGCGCTGCGGGCAGG
GTGCGTGGCCAGCGCTGGGGTCCACGAAATCTCGACGTCGACCTGATCGCCTGCTACCAGACCTCGGCCACCGAGGCTCT
GGTCGAAGTGACCGCGCGGGAGAACCACCTCACGCTGCCGCACCCACTGGCGCATCTGCGGGCCTTTGTGTTGATCCCGT
GGATTGCCGTCGACCCAACGGCGCAGCTGACGGTTGCCGGGTGCCCGCGGCCCGTCACGCGACTGCTGGCCGAGCTGGAG
CCCGCCGACCGCGACAGTGTGCGGTTGTTTAGGCTGTCGTTCGATCTGAATAGCAGACACCCCGTCAGTCGGGCACCGGA
AAGCTGA

Upstream 100 bases:

>100_bases
CGCAGGCGCCCATTCCGCAGACGTTCGACGATGTGGCGGTGGTGATCCGACGCTCACGGCGCGGCGGCCGCGGTTGGGTA
GTCCCGGCGGGCGGCGCGGT

Downstream 100 bases:

>100_bases
TGGGACCGACCCGAAAACGTGATCTGACCGCCGCGGTGGTCGGCGCCGCGGCGGTGGGATATCTGTTGGTGGCGGTGCTT
TACCGGTGGTTTCCGCCGAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase folK

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEPREWLRRAQEFERAAGR
VRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELE
PADRDSVRLFRLSFDLNSRHPVSRAPES

Sequences:

>Translated_188_residues
MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEPREWLRRAQEFERAAGR
VRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELE
PADRDSVRLFRLSFDLNSRHPVSRAPES
>Mature_187_residues
TRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEPREWLRRAQEFERAAGRV
RGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEP
ADRDSVRLFRLSFDLNSRHPVSRAPES

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=144, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20748; Mature: 20617

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP
CCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCC
TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCC
HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRLSFDLNSRH
CHHHHHHHHHHHHHEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCC
PVSRAPES
CCCCCCCC
>Mature Secondary Structure 
TRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDP
CEEEEECCCCHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCEEEEEEEECCC
TCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLP
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCC
HPLAHLRAFVLIPWIAVDPTAQLTVAGCPRPVTRLLAELEPADRDSVRLFRLSFDLNSRH
CHHHHHHHHHHHHHEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCC
PVSRAPES
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]