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The map label for this gene is disA [H]

Identifier: 148824792

GI number: 148824792

Start: 4040672

End: 4041748

Strand: Direct

Name: disA [H]

Synonym: TBFG_13619

Alternate gene names: 148824792

Gene position: 4040672-4041748 (Clockwise)

Preceding gene: 148824791

Following gene: 148824794

Centisome position: 91.33

GC content: 65.37

Gene sequence:

>1077_bases
ATGCACGCTGTGACTCGTCCGACCCTGCGTGAGGCTGTCGCCCGCCTAGCCCCGGGCACTGGGCTGCGGGACGGCCTGGA
GCGTATCCTGCGCGGCCGCACTGGTGCCCTGATCGTGCTGGGCCATGACGAGAATGTCGAGGCCATCTGCGATGGTGGCT
TCTCCCTCGATGTCCGCTATGCAGCAACCCGGCTACGCGAGCTGTGCAAGATGGACGGCGCCGTGGTGCTGTCCACCGAC
GGCAGCCGCATCGTGCGGGCCAACGTGCAACTGGTACCGGATCCGTCGATCCCCACCGACGAATCGGGGACCCGGCACCG
CTCGGCCGAGCGGGCCGCGATCCAGACCGGTTACCCGGTGATCTCAGTGAGCCACTCGATGAACATCGTGACCGTCTACG
TCCGCGGGGAACGTCACGTATTGACCGACTCGGCAACCATCCTGTCGCGGGCCAACCAGGCCATCGCAACCCTGGAGCGG
TACAAAACCAGGCTCGACGAGGTCAGCCGGCAACTGTCCAGGGCAGAAATCGAGGACTTCGTCACGCTGCGCGATGTGAT
GACGGTGGTGCAACGCCTCGAGCTGGTCCGGCGAATCGGGCTGGTGATCGACTACGACGTGGTCGAACTCGGCACTGATG
GTCGTCAGCTGCGGCTGCAGCTCGACGAGTTGCTCGGCGGCAACGACACCGCCCGGGAATTGATCGTGCGCGATTACCAC
GCCAACCCGGAACCACCGTCCACGGGGCAAATCAATGCCACCCTGGACGAACTGGACGCCCTGTCGGACGGCGACCTCCT
CGATTTCACCGCGCTGGCAAAGGTTTTCGGATATCCGACGACCACGGAAGCGCAGGATTCGACGCTGAGCCCGCGTGGCT
ACCGCGCGATGGCCGGTATCCCCCGGCTCCAGTTCGCCCATGCCGACCTGCTGGTCCGGGCGTTCGGAACGTTGCAGGGT
CTGCTGGCGGCCAGCGCCGGCGATCTGCAATCAGTGGACGGCATCGGCGCCATGTGGGCCCGTCATGTGCGCGAGGGGTT
GTCACAGCTGGCGGAATCGACCATCAGCGATCAATAA

Upstream 100 bases:

>100_bases
TACATGGTCGACATTGCCGACCACCGCGGCACCACCCTCGCAACCCCGCCCTCACATTCCGGGACTGGACACGTCCCACT
AGGGCGCGGTACATAGCAGA

Downstream 100 bases:

>100_bases
TTATCCGCCTTGCGCGGGAGACTCCGGCGGAGGCGCCTGCGCTGGACCCGGAGCGGGTACCGGCCCGGGCGGCGGCGGCG
GCTGATTCAGGATGAACGGA

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTD
GSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQG
LLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ

Sequences:

>Translated_358_residues
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTD
GSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQG
LLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ
>Mature_358_residues
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRYAATRLRELCKMDGAVVLSTD
GSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPVISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLER
YKTRLDEVSRQLSRAEIEDFVTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGIPRLQFAHADLLVRAFGTLQG
LLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions [H]

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N [H]

EC number: NA

Molecular weight: Translated: 39032; Mature: 39032

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRY
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEEEHHH
AATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPV
HHHHHHHHHHCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCE
ISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDF
EEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
HHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHEEHHHHHCCCHHHHHHHHHHCC
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGI
CCCCCCCCCEEECCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
PRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHAVTRPTLREAVARLAPGTGLRDGLERILRGRTGALIVLGHDENVEAICDGGFSLDVRY
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCEEEHHH
AATRLRELCKMDGAVVLSTDGSRIVRANVQLVPDPSIPTDESGTRHRSAERAAIQTGYPV
HHHHHHHHHHCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCE
ISVSHSMNIVTVYVRGERHVLTDSATILSRANQAIATLERYKTRLDEVSRQLSRAEIEDF
EEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTLRDVMTVVQRLELVRRIGLVIDYDVVELGTDGRQLRLQLDELLGGNDTARELIVRDYH
HHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCHHHHEEHHHHHCCCHHHHHHHHHHCC
ANPEPPSTGQINATLDELDALSDGDLLDFTALAKVFGYPTTTEAQDSTLSPRGYRAMAGI
CCCCCCCCCEEECCHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCC
PRLQFAHADLLVRAFGTLQGLLAASAGDLQSVDGIGAMWARHVREGLSQLAESTISDQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]