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The map label for this gene is atoD [C]

Identifier: 148824757

GI number: 148824757

Start: 4002680

End: 4003558

Strand: Direct

Name: atoD [C]

Synonym: TBFG_13584

Alternate gene names: 148824757

Gene position: 4002680-4003558 (Clockwise)

Preceding gene: 148824756

Following gene: 148824758

Centisome position: 90.47

GC content: 67.35

Gene sequence:

>879_bases
GTGCCCGATAAACGAACCGCTCTTGACGACGCCGTCGCGCAATTGCGCAGCGGCATGACCATCGGCATCGCCGGCTGGGG
CTCGCGGCGCAAGCCCATGGCGTTCGTGCGGGCCATCCTGCGCTCGGATGTCACCGATTTGACGGTGGTCACCTACGGCG
GGCCGGACCTGGGGCTGCTGTGCTCGGCGGGCAAGGTCAAGCGGGTCTACTACGGGTTCGTCTCGCTGGACTCGCCGCCG
TTCTACGACCCGTGGTTCGCGCACGCCCGCACCAGCGGCGCGATCGAGGCCCGGGAGATGGACGAGGGCATGCTGCGCTG
CGGTTTGCAGGCCGCGGCACAACGGCTGCCGTTCCTGCCTATTCGCGCCGGGCTGGGCAGCTCGGTACCACAGTTCTGGG
CAGGCGAGCTGCAGACGGTCACGTCGCCGTATCCGGCGCCTGGCGGCGGGTACGAGACACTGATCGCCATGCCGGCACTG
CGCCTGGATGCCGCCTTCGCCCACTTGAATCTCGGTGACAGCCACGGCAATGCGGCCTACACCGGCATCGACCCCTACTT
CGACGATCTCTTCTTGATGGCCGCCGAGCGGCGCTTTCTGTCGGTGGAGCGCATCGTCGCCACCGAGGAACTGGTCAAAT
CGGTGCCGCCGCAGGCGCTGTTGGTCAACCGGATGATGGTCGACGCCATCGTGGAAGCACCCGGCGGCGCCCACTTCACC
ACCGCCGCACCGGACTACGGGCGCGACGAGCAGTTCCAGCGGCACTACGCCGAAGCGGCGTCGACACAGGTGGGTTGGCA
GCAGTTCGTGCACACCTACCTATCCGGCACCGAAGCGGACTACCAGGCCGCGGTGCACAACTTTGGAGCATCACGGTGA

Upstream 100 bases:

>100_bases
GGGTCAATGCGAGTTACCGGATGGAGCAAGGTTTTACCTTCGAGCTCAACCTCGCCGGAGTCGCCGACGAGCACCGCGAC
GCCTTTGTGAAGAAGTCATA

Downstream 100 bases:

>100_bases
GCACCCGAGCCGAAGTGTGTGCCGTCGCCTGCGCCGAGTTGTTCCGCGATGCAGGCGAAATCATGATCAGCCCCATGACC
AACATGGCCTCGGTAGGGGC

Product: CoA-transferase subunit alpha

Products: Acetate; Butanoyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MPDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVTDLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPP
FYDPWFAHARTSGAIEAREMDEGMLRCGLQAAAQRLPFLPIRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPAL
RLDAAFAHLNLGDSHGNAAYTGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLVNRMMVDAIVEAPGGAHFT
TAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADYQAAVHNFGASR

Sequences:

>Translated_292_residues
MPDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVTDLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPP
FYDPWFAHARTSGAIEAREMDEGMLRCGLQAAAQRLPFLPIRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPAL
RLDAAFAHLNLGDSHGNAAYTGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLVNRMMVDAIVEAPGGAHFT
TAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADYQAAVHNFGASR
>Mature_291_residues
PDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVTDLTVVTYGGPDLGLLCSAGKVKRVYYGFVSLDSPPF
YDPWFAHARTSGAIEAREMDEGMLRCGLQAAAQRLPFLPIRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPALR
LDAAFAHLNLGDSHGNAAYTGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLVNRMMVDAIVEAPGGAHFTT
AAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADYQAAVHNFGASR

Specific function: Probable subunit of a CoA-transferase composed of Rv3551 and Rv3552

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y3551_MYCTU (P71850)

Other databases:

- EMBL:   BX842583
- EMBL:   AE000516
- PIR:   H70677
- RefSeq:   NP_218068.1
- RefSeq:   NP_338201.1
- ProteinModelPortal:   P71850
- SMR:   P71850
- EnsemblBacteria:   EBMYCT00000001281
- EnsemblBacteria:   EBMYCT00000069935
- GeneID:   887235
- GeneID:   922842
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3655
- KEGG:   mtu:Rv3551
- TIGR:   MT3655
- TubercuList:   Rv3551
- GeneTree:   EBGT00050000016109
- HOGENOM:   HBG754938
- OMA:   WFAKART
- ProtClustDB:   CLSK872197
- InterPro:   IPR004165
- SMART:   SM00882

Pfam domain/function: PF01144 CoA_trans

EC number: 2.8.3.8 [C]

Molecular weight: Translated: 31723; Mature: 31592

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVTDLTVVTYGGPDLGLL
CCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEE
CSAGKVKRVYYGFVSLDSPPFYDPWFAHARTSGAIEAREMDEGMLRCGLQAAAQRLPFLP
ECCCCEEEEEEEEEECCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEE
IRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPALRLDAAFAHLNLGDSHGNAAY
ECCCCCCCCHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEE
TGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLVNRMMVDAIVEAPGGAHFT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEE
TAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADYQAAVHNFGASR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDKRTALDDAVAQLRSGMTIGIAGWGSRRKPMAFVRAILRSDVTDLTVVTYGGPDLGLL
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEE
CSAGKVKRVYYGFVSLDSPPFYDPWFAHARTSGAIEAREMDEGMLRCGLQAAAQRLPFLP
ECCCCEEEEEEEEEECCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEE
IRAGLGSSVPQFWAGELQTVTSPYPAPGGGYETLIAMPALRLDAAFAHLNLGDSHGNAAY
ECCCCCCCCHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEE
TGIDPYFDDLFLMAAERRFLSVERIVATEELVKSVPPQALLVNRMMVDAIVEAPGGAHFT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEE
TAAPDYGRDEQFQRHYAEAASTQVGWQQFVHTYLSGTEADYQAAVHNFGASR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; Butyrate [C]

Specific reaction: Acetyl-CoA + Butyrate (n-C4:0) --> Acetate + Butanoyl-CoA [C]

General reaction: Coenzyme A transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036