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The map label for this gene is crt [H]

Identifier: 148824582

GI number: 148824582

Start: 3800201

End: 3800842

Strand: Direct

Name: crt [H]

Synonym: TBFG_13409

Alternate gene names: 148824582

Gene position: 3800201-3800842 (Clockwise)

Preceding gene: 148824581

Following gene: 148824583

Centisome position: 85.89

GC content: 67.45

Gene sequence:

>642_bases
ATGAGGCGGCGTGCAATGACGAAGATGGACGAGGCTAGCAATCCGTGCGGCGGGGACATCGAAGCTGAGATGTGCCAGTT
GATGCGCGAGCAACCACCCGCCGAAGGCGTCGTCGATCGTGTCGCGCTGCAACGCCATCGAAACGTTGCGTTGATCACGC
TGAGCCATCCGCAGGCGCAGAACGCACTCAACCTGGCGAGCTGGCGTCGGCTGAAGCGGCTGCTGGACGATCTCGCCGGC
GAATCGGGGCTGCGGGCGGTGGTGCTGCGGGGCGCCGGTGACAAGGCGTTCGCCGCGGGTGCCGACATCAAGGAGTTTCC
GAACACCCGCATGAGCGCCGCGGACGCCGCGGAGTACAACGAGAGCCTGGCCGTCTGCCTGAGGGCGTTGACCACGATGC
CGATCCCAGTCATCGCGGCGGTCCGGGGGCTCGCCGTCGGTGGCGGCTGTGAGCTGGCGACGGCCTGCGATGTGTGCATC
GCGACCGACGACGCGCGCTTCGGCATCCCGCTGGGCAAGCTCGGCGTCACGACGGGCTTCACCGAGGCGGACACCGTCGC
GCGCCTCATCGGTCCGGCGGCGCTGAAGTATCTGTTGTTCAGCGGAGAACTGATCGGCATTGAGGAAGCCGCCCGCTGGT
GA

Upstream 100 bases:

>100_bases
CTATGCGCGTCCTCTGCGGTGACCTGGCTGGTAGCTTAGGCACGTCTTTATCGACACCGGGTGCTGCCAGAGAACTCGAG
ACGCGGCACAGGTCGGCACC

Downstream 100 bases:

>100_bases
TTGGTGCAAAAGGTCGTCGCACCACAGGATTTGGCGGCCGCGACGGCCAAACTGGTCGGCCAGGTCTGTCGGCAATCCGC
GGTGACCATGCGTGCGGCGA

Product: enoyl-CoA hydratase echA18

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAG
ESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCI
ATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW

Sequences:

>Translated_213_residues
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAG
ESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCI
ATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW
>Mature_213_residues
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAG
ESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCI
ATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARW

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=174, Percent_Identity=37.3563218390805, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI31542718, Length=163, Percent_Identity=33.1288343558282, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI70995211, Length=179, Percent_Identity=29.608938547486, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI68989263, Length=168, Percent_Identity=35.1190476190476, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI4502327, Length=167, Percent_Identity=29.3413173652695, Blast_Score=67, Evalue=9e-12,
Organism=Escherichia coli, GI1787659, Length=168, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI221142681, Length=175, Percent_Identity=31.4285714285714, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788597, Length=167, Percent_Identity=31.1377245508982, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790281, Length=165, Percent_Identity=30.9090909090909, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788682, Length=173, Percent_Identity=32.3699421965318, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082183, Length=163, Percent_Identity=29.4478527607362, Blast_Score=68, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17540714, Length=182, Percent_Identity=29.1208791208791, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554946, Length=164, Percent_Identity=37.1951219512195, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=164, Percent_Identity=36.5853658536585, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=175, Percent_Identity=27.4285714285714, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558304, Length=176, Percent_Identity=26.7045454545455, Blast_Score=64, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17549921, Length=167, Percent_Identity=29.940119760479, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI20129971, Length=166, Percent_Identity=36.7469879518072, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653477, Length=166, Percent_Identity=36.7469879518072, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24653139, Length=176, Percent_Identity=34.0909090909091, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922422, Length=177, Percent_Identity=31.0734463276836, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 22662; Mature: 22662

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQ
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCHH
NALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYN
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHCCCCCHHHCCCCCCCHHHHHHHH
ESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGF
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHCCEEEECCCCCCCCCCHHHCCCCCC
TEADTVARLIGPAALKYLLFSGELIGIEEAARW
CHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCC
>Mature Secondary Structure
MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQ
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCHH
NALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYN
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHCCCCCHHHCCCCCCCHHHHHHHH
ESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGF
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHCCEEEECCCCCCCCCCHHHCCCCCC
TEADTVARLIGPAALKYLLFSGELIGIEEAARW
CHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]