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The map label for this gene is upp

Identifier: 148824511

GI number: 148824511

Start: 3708127

End: 3708750

Strand: Reverse

Name: upp

Synonym: TBFG_13338

Alternate gene names: 148824511

Gene position: 3708750-3708127 (Counterclockwise)

Preceding gene: 148824514

Following gene: 148824508

Centisome position: 83.82

GC content: 67.47

Gene sequence:

>624_bases
GTGCAGGTCCATGTCGTTGACCACCCACTGGCCGCGGCCCGACTGACCACGCTGCGTGACGAACGCACCGACAACGCCGG
CTTCCGGGCAGCGCTGCGCGAGCTCACGCTGCTGTTGATCTATGAGGCCACCCGCGATGCGCCCTGCGAGCCAGTCCCGA
TCCGTACGCCGCTGGCCGAGACGGTCGGGTCGCGGCTAACCAAGCCACCCCTGCTGGTTCCTGTGTTGCGGGCGGGGTTG
GGGATGGTCGACGAGGCGCATGCCGCCTTGCCGGAGGCGCACGTTGGCTTTGTCGGTGTCGCCCGCGACGAGCAAACCCA
CCAGCCGGTGCCGTATCTGGACTCGCTGCCCGACGACCTGACGGATGTACCGGTCATGGTGCTTGACCCGATGGTGGCCA
CCGGCGGGTCGATGACGCACACCCTCGGTCTGCTGATCTCGCGCGGTGCAGCGGATATCACGGTGCTGTGTGTGGTTGCG
GCGCCAGAAGGAATCGCGGCGCTGCAGAAGGCTGCGCCAAACGTGCGGTTGTTCACTGCGGCCATCGACGAAGGGCTTAA
CGAGGTCGCCTACATTGTGCCCGGTCTCGGCGATGCCGGCGATCGCCAGTTCGGCCCGCGCTGA

Upstream 100 bases:

>100_bases
GGAGTATATGGACGGGGTTGACCGGTCGCGCGGATGGACGCACCCGTATCAGCCCCCTTTTAGGGGACCGAGCCACGATT
GTTATATAGGGTTCAACGCC

Downstream 100 bases:

>100_bases
GTCACCACCACCGCCGCACGCTAGCCGACAGCTCATCGATCCTCGCCCGCACCAGCTGTCGGGCAGCTGGTAGGTCACCG
GTCACCGCGCAGCGAATCTC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAETVGSRLTKPPLLVPVLRAGL
GMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDLTDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVA
APEGIAALQKAAPNVRLFTAAIDEGLNEVAYIVPGLGDAGDRQFGPR

Sequences:

>Translated_207_residues
MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAETVGSRLTKPPLLVPVLRAGL
GMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDLTDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVA
APEGIAALQKAAPNVRLFTAAIDEGLNEVAYIVPGLGDAGDRQFGPR
>Mature_207_residues
MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAETVGSRLTKPPLLVPVLRAGL
GMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDLTDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVA
APEGIAALQKAAPNVRLFTAAIDEGLNEVAYIVPGLGDAGDRQFGPR

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=194, Percent_Identity=28.3505154639175, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI57863312, Length=194, Percent_Identity=28.3505154639175, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI87082118, Length=212, Percent_Identity=44.3396226415094, Blast_Score=178, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17539892, Length=202, Percent_Identity=28.7128712871287, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17539894, Length=202, Percent_Identity=28.7128712871287, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45550449, Length=196, Percent_Identity=28.0612244897959, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28573516, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573514, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28573512, Length=194, Percent_Identity=27.319587628866, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_MYCBO (P0A659)

Other databases:

- EMBL:   U77913
- EMBL:   BX248345
- RefSeq:   NP_856982.1
- ProteinModelPortal:   P0A659
- SMR:   P0A659
- EnsemblBacteria:   EBMYCT00000016549
- GeneID:   1092936
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb3337c
- GeneTree:   EBGT00050000016428
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- ProtClustDB:   PRK00129
- BioCyc:   MBOV233413:MB3337C-MONOMER
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 21899; Mature: 21899

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 102-102 BINDING 192-192 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAE
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHH
TVGSRLTKPPLLVPVLRAGLGMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDL
HHHHHCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCCH
TDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVAAPEGIAALQKAAPNVRLFTA
HCCCHHHCCCHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHCCCCEEEEHH
AIDEGLNEVAYIVPGLGDAGDRQFGPR
HHHCCHHHHEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAE
CEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHH
TVGSRLTKPPLLVPVLRAGLGMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDL
HHHHHCCCCCHHHHHHHHCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCCCHHCCCCCH
TDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVAAPEGIAALQKAAPNVRLFTA
HCCCHHHCCCHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHCCCCEEEEHH
AIDEGLNEVAYIVPGLGDAGDRQFGPR
HHHCCHHHHEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972