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The map label for this gene is accD5

Identifier: 148824482

GI number: 148824482

Start: 3673840

End: 3675486

Strand: Direct

Name: accD5

Synonym: TBFG_13309

Alternate gene names: 148824482

Gene position: 3673840-3675486 (Clockwise)

Preceding gene: 148824478

Following gene: 148824483

Centisome position: 83.04

GC content: 64.3

Gene sequence:

>1647_bases
ATGACAAGCGTTACCGACCGCTCGGCTCATTCCGCAGAGCGGTCCACCGAGCACACCATCGACATCCACACCACCGCGGG
CAAGCTGGCGGAGCTGCACAAACGCAGGGAAGAGTCGCTGCACCCCGTCGGTGAGGATGCCGTCGAAAAAGTACACGCCA
AGGGCAAGCTGACGGCTCGCGAGCGTATCTACGCGTTGCTGGATGAGGATTCGTTCGTCGAGCTGGACGCGCTGGCCAAA
CACCGCAGCACCAACTTCAATCTCGGTGAAAAACGCCCGCTCGGCGACGGCGTGGTCACCGGCTACGGCACCATCGACGG
GCGCGACGTGTGCATCTTCAGCCAGGACGCCACGGTGTTTGGCGGCAGCCTTGGCGAGGTGTACGGCGAGAAAATCGTCA
AGGTCCAGGAACTGGCGATCAAGACCGGCCGTCCGCTCATCGGCATCAACGACGGTGCTGGCGCGCGCATCCAGGAAGGT
GTCGTCTCGCTGGGCCTGTACAGCCGTATCTTTCGCAACAACATCCTGGCCTCCGGCGTCATCCCGCAAATCTCGTTGAT
CATGGGAGCCGCCGCCGGTGGGCACGTCTACTCCCCCGCCCTGACCGACTTCGTGATCATGGTCGATCAGACCAGCCAGA
TGTTCATCACCGGGCCCGACGTCATCAAGACCGTCACCGGCGAGGAAGTCACCATGGAAGAACTCGGCGGCGCCCACACC
CACATGGCCAAGTCGGGTACGGCACACTACGCCGCATCGGGCGAACAGGACGCCTTCGACTACGTTCGCGAGCTGCTGAG
CTACCTGCCGCCCAACAACTCCACCGACGCGCCCCGATACCAAGCCGCAGCCCCGACAGGGCCCATCGAGGAGAACCTCA
CCGACGAGGACCTCGAATTGGATACGCTGATCCCGGACTCGCCCAACCAGCCCTATGACATGCACGAGGTGATCACCCGG
CTCCTCGACGACGAATTCCTGGAGATACAGGCCGGTTACGCCCAAAACATCGTGGTGGGGTTCGGGCGCATCGACGGCCG
GCCAGTCGGCATTGTCGCCAACCAGCCGACACACTTCGCCGGCTGCCTGGATATCAACGCCTCGGAGAAAGCGGCCCGGT
TTGTGCGGACCTGCGACTGCTTCAATATCCCCATCGTCATGCTGGTGGACGTCCCGGGCTTCCTGCCGGGCACCGACCAG
GAATACAACGGCATCATCCGGCGCGGCGCCAAGCTGCTCTACGCCTACGGCGAGGCCACCGTGCCAAAGATCACGGTCAT
CACCCGCAAGGCCTACGGCGGTGCGTACTGCGTTATGGGCTCCAAAGACATGGGCTGCGACGTCAACCTGGCGTGGCCGA
CCGCGCAGATCGCGGTGATGGGCGCCTCCGGCGCAGTGGGCTTCGTGTACCGCCAGCAGCTGGCCGAGGCCGCCGCCAAC
GGCGAGGACATCGACAAGCTGCGGCTGCGGCTCCAGCAGGAGTACGAGGACACACTGGTCAACCCGTACGTGGCCGCCGA
ACGCGGATACGTCGACGCGGTGATCCCGCCGTCGCATACTCGCGGCTACATCGGGACCGCGCTGCGGCTGCTGGAACGCA
AGATCGCGCAGCTGCCGCCCAAAAAGCATGGGAACGTGCCCCTGTGA

Upstream 100 bases:

>100_bases
GCGCAGTGAGCGTTCGTCCAAAGGCGGCCTGAGCCGATCGCGGTCGGTCACCGCCCCAGCCTAAGGAAGTAGTGTGCGGC
AGCCGATAACATCGACTCCC

Downstream 100 bases:

>100_bases
GTCGAGTGAGCGGAACGAACCTGTGAGTCGAGTGAGCGGAACGAACGAAGTGAGTGACGGGAACGAGACGAACAATCCGG
CAGAAGTGAGTGACGGGAAC

Product: propionyl-CoA carboxylase beta subunit 5 accD5

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTARERIYALLDEDSFVELDALAK
HRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEG
VVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHT
HMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITR
LLDDEFLEIQAGYAQNIVVGFGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQ
EYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAAN
GEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL

Sequences:

>Translated_548_residues
MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTARERIYALLDEDSFVELDALAK
HRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEG
VVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHT
HMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITR
LLDDEFLEIQAGYAQNIVVGFGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQ
EYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAAN
GEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL
>Mature_547_residues
TSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTARERIYALLDEDSFVELDALAKH
RSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGV
VSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTH
MAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRL
LDDEFLEIQAGYAQNIVVGFGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQE
YNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAANG
EDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain

Homologues:

Organism=Homo sapiens, GI119943100, Length=523, Percent_Identity=53.1548757170172, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI295821216, Length=543, Percent_Identity=51.1970534069982, Blast_Score=510, Evalue=1e-144,
Organism=Homo sapiens, GI11545863, Length=509, Percent_Identity=32.4165029469548, Blast_Score=217, Evalue=3e-56,
Organism=Escherichia coli, GI1788655, Length=194, Percent_Identity=29.3814432989691, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=538, Percent_Identity=52.4163568773234, Blast_Score=540, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI25147359, Length=538, Percent_Identity=52.9739776951673, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17552936, Length=561, Percent_Identity=31.9073083778966, Blast_Score=246, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71997163, Length=381, Percent_Identity=22.8346456692913, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24586065, Length=538, Percent_Identity=33.0855018587361, Blast_Score=252, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCC5_MYCTU (P96885)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   A70980
- RefSeq:   NP_217797.1
- RefSeq:   NP_337908.1
- PDB:   2A7S
- PDB:   2BZR
- PDBsum:   2A7S
- PDBsum:   2BZR
- ProteinModelPortal:   P96885
- SMR:   P96885
- MINT:   MINT-3982419
- EnsemblBacteria:   EBMYCT00000003904
- EnsemblBacteria:   EBMYCT00000070754
- GeneID:   888725
- GeneID:   922476
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3379.1
- KEGG:   mtu:Rv3280
- TIGR:   MT3379.1
- TubercuList:   Rv3280
- GeneTree:   EBGT00050000015716
- HOGENOM:   HBG461319
- OMA:   HTRKSSV
- ProtClustDB:   CLSK792402
- BioCyc:   MetaCyc:RV3280-MONOMER
- BRENDA:   6.4.1.3
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762

Pfam domain/function: PF01039 Carboxyl_trans

EC number: =6.4.1.3

Molecular weight: Translated: 59355; Mature: 59224

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS50989 COA_CT_CTER; PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTAR
CCCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
ERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVF
HHEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEE
GGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGV
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHCCC
IPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHT
HHHHHHHHHCCCCCCEECCCCCEEEEEEECCCEEEEECCHHHEECCCCEEEHHHCCCCHH
HMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLEL
HHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCCEE
DTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYAQNIVVGFGRIDGRPVGIVANQPTHFA
EEECCCCCCCCCCHHHHHHHHHCCHHEEEECCCCCEEEEEEECCCCEEEEEEECCCCCEE
GCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQEYNGIIRRGAKLLYAYGEAT
EEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCC
VPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAAN
CCEEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCC
GEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPP
CCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
KKHGNVPL
CCCCCCCC
>Mature Secondary Structure 
TSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTAR
CCCCCCCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHH
ERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVF
HHEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEE
GGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGV
CCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCHHHCCC
IPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHT
HHHHHHHHHCCCCCCEECCCCCEEEEEEECCCEEEEECCHHHEECCCCEEEHHHCCCCHH
HMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLEL
HHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCCCEE
DTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYAQNIVVGFGRIDGRPVGIVANQPTHFA
EEECCCCCCCCCCHHHHHHHHHCCHHEEEECCCCCEEEEEEECCCCEEEEEEECCCCCEE
GCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQEYNGIIRRGAKLLYAYGEAT
EEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCEEEEEECCCC
VPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAAN
CCEEEEEEEECCCCEEEEECCCCCCCEEEEECCCEEEEEEECCCCHHHHHHHHHHHHHCC
GEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPP
CCHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCC
KKHGNVPL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036