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The map label for this gene is mpg1 [H]

Identifier: 148824466

GI number: 148824466

Start: 3656676

End: 3657755

Strand: Reverse

Name: mpg1 [H]

Synonym: TBFG_13293

Alternate gene names: 148824466

Gene position: 3657755-3656676 (Counterclockwise)

Preceding gene: 148824467

Following gene: 148824462

Centisome position: 82.67

GC content: 65.28

Gene sequence:

>1080_bases
TTGGCAACTCACCAAGTCGATGCGGTGGTCCTGGTCGGTGGCAAGGGTACCCGACTGCGGCCGTTGACGCTGTCGGCGCC
CAAGCCAATGCTGCCTACCGCCGGACTGCCGTTCCTCACCCATCTGCTGTCGCGGATCGCCGCAGCGGGCATCGAGCACG
TGATCCTGGGTACGTCCTACAAACCCGCAGTCTTCGAAGCGGAGTTCGGCGACGGGTCCGCACTGGGCCTACAGATCGAA
TACGTGACCGAGGAGCATCCCTTGGGGACTGGCGGCGGCATCGCCAACGTTGCCGGCAAGCTGCGCAACGACACCGCGAT
GGTGTTTAACGGCGATGTGCTCTCGGGCGCGGATCTGGCCCAACTGCTGGACTTCCACCGAAGCAATCGAGCCGATGTCA
CGCTGCAACTGGTGCGGGTGGGCGACCCGCGGGCATTCGGCTGCGTACCCACCGACGAGGAGGACCGCGTAGTCGCCTTT
CTGGAGAAGACGGAGGATCCGCCGACCGACCAGATCAATGCCGGCTGCTATGTCTTCGAACGCAACGTCATCGACCGGAT
TCCGCAGGGCCGGGAGGTTTCGGTGGAACGCGAGGTGTTCCCGGCCTTGCTCGCCGACGGCGACTGCAAGATCTACGGCT
ATGTCGATGCCAGCTATTGGCGGGACATGGGCACACCGGAAGACTTCGTTCGCGGATCGGCGGATCTGGTGCGCGGCATC
GCCCCGTCTCCGGCCTTGCGTGGTCACCGCGGTGAGCAGTTGGTGCACGACGGTGCGGCGGTATCTCCCGGTGCGTTGCT
GATTGGCGGCACCGTCGTGGGGCGTGGTGCCGAAATCGGCCCCGGCACCAGATTGGACGGCGCGGTCATCTTCGATGGTG
TCCGGGTGGAGGCCGGGTGCGTGATCGAGCGTTCGATCATCGGCTTCGGTGCTCGCATCGGACCGCGGGCGTTGATCCGC
GACGGTGTGATCGGTGACGGGGCCGACATCGGCGCGCGCTGCGAGTTGTTAAGTGGTGCCCGGGTATGGCCCGGTGTCTT
TCTTCCCGACGGCGGGATCCGTTACTCGTCCGACGTTTGA

Upstream 100 bases:

>100_bases
CTGCGGGGATCACTGGCGCTGCGTTCCCACCTCATGGTGCGCAGTTCACTGCGCAGGTCCCGCAGACGGAAACTGAAGCT
GGTAGAAGGGCGGCACTGAG

Downstream 100 bases:

>100_bases
GCTTCTTGCGCCGAGATCGACATCGTTGGCCGGGCACGCGAGGCGCTCACCCGCCGCGGTTATCGCCGAGATCCGCGCTT
GGTCCTGCGGTCGCGGAGCG

Product: D-alpha-D-mannose-1-phosphate guanylyltransferase manB

Products: NA

Alternate protein names: ATP-mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; NDP-hexose pyrophosphorylase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIE
YVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAF
LEKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI
APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIR
DGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV

Sequences:

>Translated_359_residues
MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIE
YVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAF
LEKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI
APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIR
DGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
>Mature_358_residues
ATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEY
VTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFL
EKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGIA
PSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRD
GVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV

Specific function: Catalyzes The Formation Of Dtdp-Glucose, From Dttp And Glucose 1-Phosphate, As Well As Its Pyrophosphorolysis. [C]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=357, Percent_Identity=33.6134453781513, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI11761619, Length=339, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI31881779, Length=384, Percent_Identity=26.8229166666667, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI45447090, Length=384, Percent_Identity=26.8229166666667, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1788351, Length=234, Percent_Identity=26.0683760683761, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790224, Length=238, Percent_Identity=25.2100840336134, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789837, Length=399, Percent_Identity=22.8070175438596, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=330, Percent_Identity=30.9090909090909, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17509979, Length=332, Percent_Identity=29.2168674698795, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17509981, Length=323, Percent_Identity=27.5541795665635, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320148, Length=360, Percent_Identity=28.6111111111111, Blast_Score=159, Evalue=8e-40,
Organism=Drosophila melanogaster, GI21355443, Length=347, Percent_Identity=31.700288184438, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24644084, Length=347, Percent_Identity=31.700288184438, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI24653912, Length=371, Percent_Identity=27.2237196765499, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.13 [H]

Molecular weight: Translated: 37857; Mature: 37726

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSY
CCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
KPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLA
CCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHH
QLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFE
HHHHHHCCCCCCEEEEEEEECCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEE
RNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI
CHHHHHCCCCCCEEEHHHHHHHHHCCCCEEEEEEEEHHHHHCCCCHHHHHCCCHHHHHCC
APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGC
CCCCCCCCCCCCHHHHCCCCCCCCEEEEECEEEECCCCCCCCCCCCCEEEEECEEEECCE
VIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
EEEEHHHHCCCCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCEEECCCC
>Mature Secondary Structure 
ATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSY
CCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCC
KPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLA
CCEEEEEECCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCHHHH
QLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFE
HHHHHHCCCCCCEEEEEEEECCCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEE
RNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGI
CHHHHHCCCCCCEEEHHHHHHHHHCCCCEEEEEEEEHHHHHCCCCHHHHHCCCHHHHHCC
APSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGC
CCCCCCCCCCCCHHHHCCCCCCCCEEEEECEEEECCCCCCCCCCCCCEEEEECEEEECCE
VIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
EEEEHHHHCCCCCCCHHHHHCCCCCCCCCCCCEEEEECCCCCCCEEEECCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8334170 [H]