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The map label for this gene is manA [H]

Identifier: 148824457

GI number: 148824457

Start: 3646819

End: 3648045

Strand: Reverse

Name: manA [H]

Synonym: TBFG_13284

Alternate gene names: 148824457

Gene position: 3648045-3646819 (Counterclockwise)

Preceding gene: 148824458

Following gene: 148824455

Centisome position: 82.45

GC content: 66.83

Gene sequence:

>1227_bases
GTGGAACTGCTACGTGGCGCGTTACGCACCTACGCTTGGGGATCGCGCACCGCTATCGCCGAATTCACCGGGCGTCCGGT
GCCGGCCGCTCACCCCGAGGCCGAACTATGGTTCGGTGCACACCCGGGTGATCCGGCTTGGCTGCAGACGCCGCATGGCC
AAACCTCGTTGCTCGAAGCGTTGGTCGCGGATCCGGAGGGGCAGCTCGGCTCCGCGTCGCGCGCGCGATTCGGCGATGTG
TTGCCGTTCTTGGTCAAGGTGTTGGCGGCCGACGAGCCACTATCGTTGCAGGCCCATCCGAGCGCCGAGCAGGCGGTTGA
GGGCTACCTGCGGGAAGAGCGAATGGGCATTCCGGTGTCCTCACCCGTCCGCAACTACCGCGACACCAGTCACAAGCCAG
AGTTATTGGTGGCGCTGCAGCCGTTCGAGGCGCTGGCCGGATTCCGGGAGGCGGCTCGCACCACCGAGCTGCTGCGGGCG
CTGGCCGTATCCGACCTCGACCCGTTCATCGACTTGCTGAGCGAGGGGTCCGATGCCGATGGTTTGCGTGCGCTGTTCAC
CACCTGGATTACCGCACCCCAGCCCGACATCGACGTGCTGGTGCCTGCCGTGCTGGACGGCGCTATCCAGTACGTCAGCT
CCGGCGCAACGGAATTTGGCGCCGAAGCCAAGACAGTGCTGGAACTCGGCGAACGTTATCCCGGCGACGCCGGTGTGCTG
GCGGCGTTGTTGCTCAACCGCATCAGCTTGGCTCCTGGGGAGGCGATCTTCCTGCCGGCCGGCAACCTGCACGCCTATGT
GCGTGGTTTCGGTGTGGAAGTGATGGCCAACTCCGACAACGTGTTACGCGGTGGACTTACCCCTAAGCACGTCGATGTGC
CCGAGTTGTTGCGGGTGCTGGACTTCGCCCCCACGCCGAAGGCTCGGCTGCGGCCCCCGATCCGGCGCGAGGGGCTGGGG
CTGGTCTTTGAGACGCCCACCGATGAGTTCGCGGCCACGCTACTGGTGCTCGACGGCGATCACCTCGGCCACGAGGTCGA
CGCGTCGTCCGGCCATGACGGTCCACAGATCTTGTTATGCACCGAGGGTTCGGCGACGGTGCACGGGAAGTGCGGGTCGC
TCACGCTACAGCGCGGCACGGCCGCCTGGGTGGCGGCCGACGACGGCCCGATCCGGCTGACCGCCGGCCAACCCGCCAAG
CTGTTCAGGGCGACCGTCGGGTTGTGA

Upstream 100 bases:

>100_bases
GAGCTGCTCGACGCCCCCGTGGGATCCGGGGGGGCGGTATTGGCCGTTCGGCTGGAGATGGCCGCCGTGTATCTGCGACT
GGTGCGAGGATAGATCGCCG

Downstream 100 bases:

>100_bases
CGGGTTGCCGACGCTCACGCTGCTCTTTTAGCCACAATCGCAGATTGTGAGCAATGGCGCGACCGATGATCGGTACCGAC
GGCACCATGTACAGGCTGTC

Product: mannose-6-phosphate isomerase manA

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEALVADPEGQLGSASRARFGDV
LPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRA
LAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVL
AALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLG
LVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAK
LFRATVGL

Sequences:

>Translated_408_residues
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEALVADPEGQLGSASRARFGDV
LPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRA
LAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVL
AALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLG
LVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAK
LFRATVGL
>Mature_408_residues
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEALVADPEGQLGSASRARFGDV
LPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRA
LAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVL
AALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLG
LVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAK
LFRATVGL

Specific function: Involved in the conversion of glucose to GDP-L-fucose, which can be converted to L-fucose, a capsular polysaccharide [H]

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

Organism=Homo sapiens, GI4505235, Length=430, Percent_Identity=31.6279069767442, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1787899, Length=405, Percent_Identity=37.7777777777778, Blast_Score=258, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71997620, Length=411, Percent_Identity=32.6034063260341, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17557650, Length=345, Percent_Identity=28.9855072463768, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320839, Length=417, Percent_Identity=29.7362110311751, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI21356061, Length=404, Percent_Identity=28.4653465346535, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR016305
- InterPro:   IPR018050
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 43372; Mature: 43372

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEA
CHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCCEEECCCCHHHHHHH
LVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVS
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCC
SPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRALAVSDLDPFIDLLSEGSDAD
CHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
GLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHCCCCCHHHH
AALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEEECCCCEEEEEECCEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLC
CCCCCCHHHCCCCHHHCCCEEEEECCCHHHEEEEEEEECCCCCCCCCCCCCCCCCEEEEE
TEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAKLFRATVGL
ECCCCEEECCCCCEEEECCCEEEEEECCCCEEEECCCCHHHHHHHCCC
>Mature Secondary Structure
MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEA
CHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCEEECCCCCCCCEEECCCCHHHHHHH
LVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVS
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCCC
SPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRALAVSDLDPFIDLLSEGSDAD
CHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCC
GLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHCCCCCHHHH
AALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVL
HHHHHHHHCCCCCCEEEEECCCCEEEEEECCEEEEECCCCEEECCCCCCCCCHHHHHHHH
DFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLC
CCCCCCHHHCCCCHHHCCCEEEEECCCHHHEEEEEEEECCCCCCCCCCCCCCCCCEEEEE
TEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAKLFRATVGL
ECCCCEEECCCCCEEEECCCEEEEEECCCCEEEECCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6397402; 9097039; 9278503 [H]