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The map label for this gene is ahcY [H]

Identifier: 148824450

GI number: 148824450

Start: 3639938

End: 3641425

Strand: Reverse

Name: ahcY [H]

Synonym: TBFG_13277

Alternate gene names: 148824450

Gene position: 3641425-3639938 (Counterclockwise)

Preceding gene: 148824451

Following gene: 148824449

Centisome position: 82.3

GC content: 63.78

Gene sequence:

>1488_bases
ATGACCGGAAATTTGGTGACCAAAAATTCGCTGACCCCTGACGTTCGTAACGGCATCGACTTTAAGATCGCCGACCTGTC
ACTAGCGGATTTCGGCCGCAAAGAACTCCGGATCGCCGAGCACGAGATGCCCGGCCTGATGTCGCTGCGGCGCGAGTATG
CCGAGGTGCAACCCCTGAAGGGGGCCCGGATCTCGGGTTCGCTGCACATGACGGTGCAGACCGCGGTGTTGATCGAAACC
CTCACCGCGCTGGGCGCCGAAGTCCGCTGGGCCTCGTGCAACATCTTCTCCACCCAGGATCACGCCGCCGCCGCCGTCGT
GGTCGGCCCGCACGGCACCCCCGACGAGCCCAAGGGTGTCCCGGTGTTCGCGTGGAAGGGCGAGACGCTCGAAGAGTACT
GGTGGGCCGCCGAGCAGATGCTCACCTGGCCGGACCCCGACAAGCCGGCCAACATGATCCTCGATGACGGCGGTGACGCC
ACCATGTTGGTGCTGCGCGGCATGCAGTATGAGAAGGCCGGCGTGGTGCCGCCCGCCGAGGAGGACGACCCCGCCGAGTG
GAAGGTCTTCCTGAACCTGCTACGGACCCGCTTCGAGACCGACAAGGACAAGTGGACCAAGATAGCCGAGTCGGTCAAGG
GCGTCACCGAGGAGACCACCACCGGCGTGCTGCGGCTCTACCAATTCGCCGCGGCCGGGGATCTGGCCTTCCCGGCGATC
AACGTCAACGACTCGGTGACCAAGTCCAAATTCGACAACAAGTACGGCACTCGGCACTCCCTGATCGACGGCATCAACCG
CGGCACCGACGCGCTGATCGGCGGTAAGAAGGTCCTCATCTGCGGCTACGGCGACGTCGGTAAGGGCTGTGCGGAGGCGA
TGAAGGGCCAGGGAGCGCGGGTCTCCGTCACCGAGATCGACCCGATCAACGCGCTGCAGGCCATGATGGAGGGCTTCGAC
GTGGTCACCGTCGAGGAGGCCATCGGGGACGCCGACATCGTCGTAACCGCGACCGGCAACAAAGACATCATCATGCTCGA
GCACATTAAGGCGATGAAGGACCACGCGATCCTGGGAAATATCGGCCACTTCGACAACGAGATCGACATGGCCGGGCTGG
AGCGCTCCGGGGCGACACGGGTCAACGTCAAGCCTCAGGTCGACCTGTGGACCTTTGGCGACACGGGCCGCTCGATCATC
GTGCTGTCCGAGGGGCGGCTGCTGAACCTGGGCAATGCCACCGGGCACCCCTCGTTCGTGATGAGCAACAGCTTCGCTAA
CCAGACGATCGCCCAGATCGAGCTGTGGACCAAGAACGACGAGTACGACAACGAGGTGTACCGGCTGCCCAAGCACCTCG
ACGAGAAGGTGGCTCGAATCCATGTCGAGGCCCTTGGCGGTCACCTGACCAAGCTGACCAAGGAGCAGGCCGAATACCTC
GGCGTCGACGTCGAGGGTCCCTACAAGCCGGACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
CGGGGCTGACCGACGGCGGCTACAGTGACTGCAAGAGCGTACCTAGGCTAAGTAGCCCGCTCGGATCCCTGTGAGCCCCC
AAAGAAGGATGAAAGCCCCT

Downstream 100 bases:

>100_bases
GTGCCTCCCACCCGCGAGCAGACGCAAAATCGCCCATTTTCATGACGAAAAGGGCGATTTTGCGTCTGCTCGCGCCGCCA
CCGACAGGGCCGCGCCGTGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 495; Mature: 494

Protein sequence:

>495_residues
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIET
LTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDA
TMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAI
NVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFD
VVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSII
VLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL
GVDVEGPYKPDHYRY

Sequences:

>Translated_495_residues
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIET
LTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDA
TMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAI
NVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFD
VVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSII
VLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL
GVDVEGPYKPDHYRY
>Mature_494_residues
TGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETL
TALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDAT
MLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAIN
VNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDV
VTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIV
LSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLG
VDVEGPYKPDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=477, Percent_Identity=55.9748427672956, Blast_Score=507, Evalue=1e-143,
Organism=Homo sapiens, GI239937451, Length=453, Percent_Identity=56.0706401766004, Blast_Score=482, Evalue=1e-136,
Organism=Homo sapiens, GI298286489, Length=480, Percent_Identity=45.4166666666667, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI195539337, Length=480, Percent_Identity=45.4166666666667, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI24308043, Length=480, Percent_Identity=45.4166666666667, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI195539349, Length=480, Percent_Identity=45.4166666666667, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI21361647, Length=480, Percent_Identity=43.75, Blast_Score=403, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17506425, Length=478, Percent_Identity=55.8577405857741, Blast_Score=515, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6320882, Length=490, Percent_Identity=54.0816326530612, Blast_Score=494, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24642172, Length=475, Percent_Identity=57.4736842105263, Blast_Score=520, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24656245, Length=497, Percent_Identity=45.8752515090543, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45553387, Length=478, Percent_Identity=46.4435146443515, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI45553385, Length=477, Percent_Identity=46.3312368972746, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 54324; Mature: 54193

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLK
CCCCEEECCCCCCHHHCCCCEEEEECCHHHCCCHHEEEHHHCCCHHHHHHHHHHHCCCCC
GARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGV
CCEECCEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCC
PVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAE
EEEEECCCCHHHHHHHHHHEECCCCCCCCCCEEEECCCCEEEEEEECCCHHHCCCCCCCC
EDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAI
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEE
NVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGAR
CCCCCHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCEEEEEECCCCCHHHHHHHCCCCCE
VSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGN
EEEEECCCHHHHHHHHCCCCEEEEHHHCCCCEEEEEECCCCCEEEHHHHHHHHCCEEECC
IGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFV
CCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEE
MSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL
EECCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHE
GVDVEGPYKPDHYRY
ECCCCCCCCCCCCCC
>Mature Secondary Structure 
TGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLK
CCCEEECCCCCCHHHCCCCEEEEECCHHHCCCHHEEEHHHCCCHHHHHHHHHHHCCCCC
GARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGV
CCEECCEEEEEHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCC
PVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAE
EEEEECCCCHHHHHHHHHHEECCCCCCCCCCEEEECCCCEEEEEEECCCHHHCCCCCCCC
EDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAI
CCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEE
NVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGAR
CCCCCHHHHHHCCCCCCHHHHHHHCCCCCCEEECCCEEEEEECCCCCHHHHHHHCCCCCE
VSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGN
EEEEECCCHHHHHHHHCCCCEEEEHHHCCCCEEEEEECCCCCEEEHHHHHHHHCCEEECC
IGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFV
CCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCEEEEEECCCEEECCCCCCCCCEE
MSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYL
EECCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHEEHHHHCCHHHHHHHHHHHHE
GVDVEGPYKPDHYRY
ECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]