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The map label for this gene is hcr [C]

Identifier: 148824432

GI number: 148824432

Start: 3618890

End: 3620032

Strand: Reverse

Name: hcr [C]

Synonym: TBFG_13259

Alternate gene names: 148824432

Gene position: 3620032-3618890 (Counterclockwise)

Preceding gene: 148824433

Following gene: 148824431

Centisome position: 81.82

GC content: 66.84

Gene sequence:

>1143_bases
ATGAGCAAGAAACACACGACGCTTAACGCCAGCATCATCGACACCAGGCGCCCCACCGTCGCCGGAGCCGACCGGCATCC
GGGCTGGCATGCGCTGCGCAAGATTGCCGCGCGCATCACGACGCCATTGTTGCCCGACGACTACCTTCACCTGGCAAATC
CGCTGTGGTCCGCGCGGGAATTGCGGGGGCGCATCCTAGGGGTCCGCCGAGAGACGGAAGACTCCGCGACCCTGTTCATC
AAACCGGGCTGGGGCTTCAGTTTCGACTACCAGCCGGGCCAATACATCGGGATCGGGCTGCTGGTCGACGGGCGCTGGCG
CTGGCGGTCGTATTCGCTGACGTCGAGTCCGGCGGCATCCGGGTCCGCGCGCATGGTGACCGTCACGGTGAAGGCGATGC
CCGAGGGCTTCCTGTCCACCCACTTGGTGGCCGGGGTAAAGCCAGGGACCATTGTGCGGCTGGCTGCGCCCCAGGGCAAT
TTCGTATTACCGGATCCGGCGCCCCCGTTGATTCTGTTTTTGACTGCCGGGTCGGGGATTACGCCGGTAATGTCGATGCT
TCGAACGTTGGTGCGCCGCAACCAAATCACCGACGTAGTGCACCTGCATTCGGCGCCCACCGCAGCTGACGTGATGTTCG
GTGCCGAGCTGGCTGCCCTGGCGGCCGACCATCCCGGTTATCGGTTGTCGGTGCGCGAGACGCGCGCCCAGGGCCGGCTG
GACCTGACCCGGATCGGTCAGCAGGTGCCGGACTGGCGTGAACGCCAGACCTGGGCGTGCGGGCCGGAGGGCGTGCTCAA
CCAGGCCGACAAGGTCTGGTCATCGGCGGGTGCCAGCGACCGACTGCACCTGGAGCGGTTCGCAGTGTCCAAAACGGCGC
CCGCTGGAGCGGGCGGGACCGTCACGTTCGCCCGAAGTGGCAAGAGCGTAGCCGCCGATGCTGCCACGTCGTTGATGGAC
GCCGGTGAGGGCGCCGGCGTGCAGCTACCCTTCGGCTGCCGGATGGGCATCTGCCAGTCGTGTGTGGTCGACCTGGTGGA
AGGCCATGTTCGGGATCTGCGCACGGGCCAGCGGCATGAGCCCGGAACCCGGGTCCAGACCTGCGTGTCGGCCGCCTCGG
GTGATTGCGTGCTGGACATCTAG

Upstream 100 bases:

>100_bases
GGGTGTGACGCAGTCTGCGCGTCCGGGCCTAGATACGGAACCGTAGGTTACGGTACCGTAGCTTTGTTGGGCGGAAGCTA
AGGCCGAGCAGGAGCTTCCT

Downstream 100 bases:

>100_bases
TGTTACTCATAGGTAACCTACGGAATCGTAAGTTACGATAGCGTAGGTCATCGGCCGTATGACGCAGGGAGAAGACGATG
GCGATCACTGACGTCGACGT

Product: oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 379

Protein sequence:

>380_residues
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFI
KPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGN
FVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRL
DLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMD
AGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI

Sequences:

>Translated_380_residues
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFI
KPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGN
FVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRL
DLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMD
AGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI
>Mature_379_residues
SKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIK
PGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNF
VLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLD
LTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDA
GEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI

Specific function: This is an electron transfer partner for desA3

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain

Homologues:

Organism=Escherichia coli, GI1787098, Length=295, Percent_Identity=28.135593220339, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787658, Length=321, Percent_Identity=26.4797507788162, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788903, Length=218, Percent_Identity=28.4403669724771, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788104, Length=293, Percent_Identity=27.9863481228669, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323510, Length=192, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DESET_MYCTU (O05875)

Other databases:

- EMBL:   BX842582
- EMBL:   AE000516
- PIR:   H70590
- RefSeq:   NP_217747.1
- RefSeq:   NP_337856.1
- HSSP:   P00235
- ProteinModelPortal:   O05875
- SMR:   O05875
- EnsemblBacteria:   EBMYCT00000000833
- EnsemblBacteria:   EBMYCT00000071858
- GeneID:   888748
- GeneID:   922787
- GenomeReviews:   AE000516_GR
- GenomeReviews:   AL123456_GR
- KEGG:   mtc:MT3327
- KEGG:   mtu:Rv3230c
- TIGR:   MT3327
- TubercuList:   Rv3230c
- GeneTree:   EBGT00050000015208
- HOGENOM:   HBG639280
- OMA:   HWRSYSL
- ProtClustDB:   CLSK792362
- GO:   GO:0005737
- GO:   GO:0006810
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR00371
- PRINTS:   PR00410

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1; SSF54292 Ferredoxin; SSF63380 Riboflavin_synthase_like_b-brl

EC number: 1.-.-.- [C]

Molecular weight: Translated: 40795; Mature: 40664

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00197 2FE2S_FER_1; PS51085 2FE2S_FER_2; PS51384 FAD_FR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARE
CCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHH
LRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAAS
HHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCC
GSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGI
CCCEEEEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCEEEEEECCCCH
TPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRL
HHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCC
DLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGT
CHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCE
VTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHE
EEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PGTRVQTCVSAASGDCVLDI
CCHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure 
SKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARE
CCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHH
LRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAAS
HHHHEEEEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCC
GSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGI
CCCEEEEEEEEECCCHHHHHHHHCCCCCCEEEEEECCCCCEECCCCCCCEEEEEECCCCH
TPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRL
HHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHCCCCC
DLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGT
CHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHCCCCCCCCCCE
VTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHE
EEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PGTRVQTCVSAASGDCVLDI
CCHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036